Protein Alignment Tmem131 and tmem131

DIOPT Version :10

• Sequence 1: NP_611073.2
• Gene: Tmem131 / 36761
• FlyBaseID: FBgn0034060
• Length: 1567
• Species: Drosophila melanogaster
• Sequence 2: XP_031751604.1
• Gene: tmem131 / 100216097
• XenbaseID: XB-GENE-955763
• Length: 1885
• Species: Xenopus tropicalis
• Alignment Length: 1744
• Identity: 423/1744 - (24%)
• Similarity: 713/1744 - (40%)
• Gaps: 337/1744 - (19%)

  Fly    12 RIFAEPILLILIFLFTLGA---------KGEKVLQ------------ETFLGL-----QEAPIH- 49
            ||....|..:||.|.||..         :.|.|::            ||.:||     :...:|
 Frog    32 RISCNGIYSVLIALLTLHTARTHTEAFIQSENVIEVLRFDDGGLLEAETTIGLRSYQQKSMSLHR 96

  Fly    50 -DLGDLRLVPSRLDFGTWSVGQARSQTVTLFNQHSNRTLQLNAVAGPSPAFYSSFLGTREVPPQG 113
             :...:|..|..|||....||..:.:.|.|.|..|..|:.|.:::..:..|::||...|::.|.|
 Frog    97 GNCRPIRFEPPMLDFHEQPVGMPKMEKVYLHNPSSEETITLISISATTSHFHASFFQNRKILPGG 161

  Fly   114 NTTFNVVFLPRQLGAIAADLLIHTS-FGQAELAVQGEGSECPYRLKPLVGIKAPMNATLTPEIHM 177
            ||:|:||||.|.:|.:...|.|:|| .|.....|.|.|...||||:|.:|.:.|:|::.:|.|::
 Frog   162 NTSFDVVFLARVVGNVENTLFINTSNHGVFTYQVFGIGIPNPYRLRPFIGARVPVNSSFSPLINI 226

  Fly   178 YNPHERPLQILEIYSSGGEFQLELPSGGSEGPQNLWKIPPHTLKPVIRISFHGRTAGNHSAYIRI 242
            :|||..|||::|:|||||:..||||:|...|.:.||:|||:..|.|:|.||..|.|.||:|:|||
 Frog   227 HNPHSEPLQVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRI 291

  Fly   243 K--VAEQELDIFIPVEFEILPRHSVYARNPLADFGRVATLNAPDALQFKL------DV------- 292
            |  .::....|.:|||.|:.....:|:...:.|||.:.|.:||..|...|      ||
 Frog   292 KTNASDSAEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDAPKVLNLHLLNSGMKDVPITSVRS 356

  Fly   293 --RNDESRQLF--------GSYLRQIPGLSFDANNTSIVLDASLFEGDEIINDLLVINSNQSSTS 347
              :||.....|        .|...::..:||||:...   ..|.|.|.      :.:.:.:.|.|
 Frog   357 TPQNDAVTVHFKPITLKASESKYTKVASISFDASKAK---KPSQFSGK------ITVKAKEKSYS 412

  Fly   348 PGADQPFTVLVRAEIFHGGLTFDRNATRF-VTTSPEGVEGEPLERKRSLVVRNKFAIPLMLFNVS 411
            . .:.|:    :||:..|.|.||..||.| :..||    .:|:|  |::.:.|.|...:::.:|.
 Frog   413 K-LEIPY----QAEVLDGYLGFDHAATLFHIRDSP----SDPVE--RAIYLTNTFNFAVLIHDVL 466

  Fly   412 LTEPIDESILEVTLVGDPRILIQPDESVELLRLNLL--NDQVPFKSFLRIETNVTVFKLPLVSCS 474
            |  |.|...:.........:||.|.||..:..|...  ...|...|.:.:.||.:.|.||:.:.:
 Frog   467 L--PEDAKPMFKIQNFSSHVLIPPGESRYIFSLLFTPSTSSVHIDSNILLITNASKFHLPVRAYT 529

  Fly   475 GRLHVSTQPIVLNFRQESLEKAAYNLELDLGTVPFAEMSRDGFVILRNDNPVPVRITNWF-FKHP 538
            |.|.....|..|..|           .:|.|.:..:| |....:.:.|.||:.:.|.:|. ....
 Frog   530 GFLDYFILPPKLEER-----------FIDFGILSASE-SSSLLIAIMNSNPIELAIKSWLVIGDS 582

  Fly   539 KTVYSQSTFLGCRATAIGHPVSVENDTKGWHLCTEIRAGESAVFKVAIQTYEADATF-GTLKVWT 602
            .::...:|..|.|.:.|.....:||.|........:.:|..|||:|:|...:.:.:: |.:::.|
 Frog   583 LSIDLLTTEKGNRTSIIASLPEIENATVSDRTSVILTSGYYAVFRVSIIAKDLEGSYDGGIQITT 647

  Fly   603 PYEVIRVRVKFEASVGHLEIDQEQLSFKNCFPGKMCTAVLSIRSSFTHPVHVKGI-SFALPVGLR 666
            .||::.|.||...:||.|....::::....||||:....|:|.|||:..|.::.| |.:..|...
 Frog   648 DYEILTVPVKAVVAVGSLTCSPKRITLPPSFPGKVVHQSLNIMSSFSQKVKIQQIRSLSEDVRFF 712

  Fly   667 FKDFNAKGTTIAPQTLTKVGRIYFDPASVCRNNCYIRESTNDLAIFPSVPGGGN--------GNS 723
            :|...:....:.|...:|:..||||.|..|.::|||...    .:|.|...|.:        .:.
 Frog   713 YKRLRSNKDELEPGKKSKIANIYFDAALNCGDHCYIGLP----FLFKSESKGQHLAMQEDLWDSD 773

  Fly   724 GVINNNLLYDGVELRQRT--------ELFRQLRRQLSSMSLTLHSEELPPLELDFSITIEWPKLV 780
            .....||.....|:|:.:        |:...|::.:.|               |....:.||.:|
 Frog   774 WDYYENLYKKWSEIRENSDHLLEAAFEVDTDLQKNILS---------------DVKAELMWPSVV 823

  Fly   781 QFQPIPPTPAIEVGQVQRQWITLTNPSQSPL---------------LLDYFLSDPAFARRTQLSL 830
            ........|.........:.:.|.|||.:|:               ||:..:.....::...:.|
 Frog   824 SSSRYIRFPLTNTNSSTVEEMFLENPSDAPVYIQILPLALYSNNSFLLERIIDRFNISKSVDIDL 888

  Fly   831 P--------HEVIDVSSTSCYLTDKEVFSLPEAGDPILLPGGASLTIPITFSAQLPEKYCTLLHV 887
            .        :.|..|.|:..::......|:..    ::|..|....:.:.|:....:...:||.|
 Frog   889 KTLEFQVFRNNVNPVQSSHSFVEGSSRHSVLN----LVLKSGEKQNVKLKFTPVQNQTVSSLLIV 949

  Fly   888 RSNLTLYEAVWLQARAVQSQFRFGNRRPGAASPLLFEMATNQFQGC----QSGNEAVVVTRSFTA 948
            |:|||:.:.:.::.:..:...:...:.||..|.|.|::.....:.|    :.......:.|:|..
 Frog   950 RNNLTVIDVIMVEGQGAKENLKVAGKPPGPGSSLRFKITEAFLKDCTDKIKHREPNFTMKRTFKL 1014

  Fly   949 RNSGVIPIRIEGFLIGSLPCEDFGFKVMDCAGFDLGENEARKVEIAFSADFTTSAVKRSLTLLTN 1013
            .|:|.:.:.::...|....||.:|||:::|..|.||.|.:|:|.|.|:.|||:|.|.|.|.::|.
 Frog  1015 ENTGQLDVTVKSMEISGYSCEGYGFKILNCNEFALGPNASREVTILFTPDFTSSRVIRELRIVTE 1079

  Fly  1014 LTYDISYKLLAQMPAESVELCASLLVRPGWESSLKNAALVVLLASFGLVLVAAVFDAKAI---MV 1075
            ...:..:.|.|.:|...:..||..|.||.||.:|......::...|.||:|.|..:|:.|   ..
 Frog  1080 GGSEFVFILNASLPYHMLATCAEALPRPNWELALYVIISGIMSLLFLLVIVTAYLEAQGIWEPFK 1144

  Fly  1076 QQNAYDAARNKGPLQPTFNLRNIVKLQAEEAAAKAESVQQQQKVKNGQLKELRKRT--------- 1131
            ::.::::|.........|:||.||.:.:|.:.....|.......:.........||
 Frog  1145 RRLSFESAHPSIVFGRPFDLRRIVGISSESSFNSVGSDSNHSSNRGLYTGSTSTRTGAGNQKPCN 1209

  Fly  1132 -VVNSTNSKSKSKSSWSPWSMDMNALSKHLQKAKPKTVVSTPVTPPAASAPAAAPVPLPEAKPV- 1194
             |.|..||:|...:..|......|..||...:|        .|..|::.||:    |..::..|
 Frog  1210 PVSNLQNSRSAPDAELSRPKNSSNIASKLSSQA--------AVAQPSSKAPS----PQTDSNTVV 1262

  Fly  1195 -KKSSTPSPQGVPISVQVRPQKKV--KPTPAVVLGTTKPKQEVSTPVAD---------------Q 1241
             .::.|...:|..:|.....|:::  .|:|||.....:.:.|:|.||..               :
 Frog  1263 QNQALTRRTRGTRLSQNQVSQEQLPSTPSPAVPPPQAEQQAEISQPVTSNTSHPEYFRASSSNAR 1327

  Fly  1242 H--------------EKSLAKSSPPQQENISPKPNKPPEQRVLKEQNGSAKKMGKT--PGRERER 1290
            |              :|...:|.....:..:.:|..|    |||.:..:...|.|:  ..::.|:
 Frog  1328 HSSDDSDITNLIEAMDKDFDQSEITHSDVFTEQPPSP----VLKNKGKTRSVMHKSKFQKKQEEK 1388

  Fly  1291 ERRSKDQKLTNGTGAGVGFRKPERKQRQKL---NFGQTTNSTS-----PPESPDALKCISNPWET 1347
            :||.|.::|             |.:.:..|   :...||..||     ||...|..|....  :|
 Frog  1389 DRRIKGKQL-------------EDELKDSLADDDSSSTTTETSNPDTEPPVKEDGEKLKGK--QT 1438

  Fly  1348 SSRVSFRDVLRTPQMAPTDNGFDWNHATSSSDLGPIG----DNRKNATPPMVTS-LWEPLSATAS 1407
            ....|.|::|:                     :.|.|    :|:|.:.|.:..| ::..
 Frog  1439 IPVKSEREILK---------------------VKPKGKKAANNKKESIPEVKQSHVFHH------ 1476

  Fly  1408 NSLFANTEVDFITPDAIYEQRERE---------------KPQWEQR-----SDLVMRQQLLLQQP 1452
               |::.|:.:.||   .|.::|:               ||:..|:     |.||..:|.|.:.
 Frog  1477 ---FSSLELPYTTP---LENKQRKNFSKITVQNPLLNGSKPKTLQKARGTSSKLVDNRQSLAKY- 1534

  Fly  1453 QKLEFQLRQQEKISLLANMDPSNWATNWSPLGYSTWPNATAGIGVMRPPPGLEQSARQTHN---- 1513
              |..:..|:     |.|...|....:..|..:.:.|...||...    ..|.:.:.:||:
 Frog  1535 --LPCRTGQE-----LGNTSSSEGEKDSPPPEWDSVPIHKAGSSA----DSLYKLSLRTHHADDF 1588

  Fly  1514 LAQEQVSAGPASGTGAALHGESLPTQYDPFTSPSSIWSDTWRQSSQRNNHNHMN 1567
            |.|.|.|..|.|                |...||:.:......||..|:.|:::
 Frog  1589 LKQRQTSPAPTS----------------PSPPPSASFVARGSYSSIVNSTNNLD 1626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmem131	NP_611073.2	TMEM131_like_N	54..137	CDD:463553	30/82 (37%)
		TMEM131_like	<880..>1064	CDD:437364	54/187 (29%)
tmem131	XP_031751604.1	TMEM131_like_N	103..185	CDD:463553	30/81 (37%)
		TMEM131_like	330..1808	CDD:437364	316/1446 (22%)