Protein Alignment Tmem131 and tmem131l

DIOPT Version :10

• Sequence 1: NP_611073.2
• Gene: Tmem131 / 36761
• FlyBaseID: FBgn0034060
• Length: 1567
• Species: Drosophila melanogaster
• Sequence 2: XP_002933525.2
• Gene: tmem131l / 100144926
• XenbaseID: XB-GENE-983404
• Length: 1610
• Species: Xenopus tropicalis
• Alignment Length: 1771
• Identity: 341/1771 - (19%)
• Similarity: 587/1771 - (33%)
• Gaps: 592/1771 - (33%)

  Fly    54 LRLVPSRLDFGTWSVGQARSQTVTLFNQHSNRTLQLNAVAGPSPAFYSSFLGTREVPPQGNTTFN 118
            |.|.||.|||||.|:|..:.||...||...:|.:::|:|......|:.|.:.:|.:|.:|..:|.
 Frog    87 LHLQPSVLDFGTQSLGLPKVQTFCAFNPCRDRDVEVNSVFTSGRHFHVSPIQSRVIPARGKASFT 151

  Fly   119 VVFLPRQLGAIAADLLIHT-SFGQAELAVQGEGSECPYRLKPLVGIKAPMNATLTPEI---HMYN 179
            |||||.:.|:..:.:.|:| |.|.....|.|.|.       |..|.....||.....:   |:.|
 Frog   152 VVFLPDEEGSFESSIFINTSSHGILSYQVFGVGI-------PAAGSDDYKNALQNTNVIFPHIAN 209

  Fly   180 PHERPLQILEIYSSGGEFQLE--------------LPSGGSEGPQNLWKIPPHTLKPVIRISFHG 230
            .|....|...|.||..:.:|:              ||||             |:|  :::|.|..
 Frog   210 IHLSQSQAEAINSSVWQVRLKCSVPFKKHQLGKNCLPSG-------------HSL--LLQIYFAV 259

  Fly   231 R-TAGNHS-AYIRIKVAEQELDIFIPVEFEILPRHSVYARNPLADFGRVATLNAPDALQFKLDVR 293
            | ..|.|. ..:|..|.|....||      :...|.....:|:..   |..||:.:.|....||.
 Frog   260 RLDGGQHDLETLRNYVLENIFMIF------VTSNHIGNIDDPIIG---VYVLNSGNGLVHMQDVH 315

  Fly   294 NDESRQLFGSYLRQIPGLSFDANNTSIVLDASL--------------------FEGDEIINDLLV 338
            :         :|..|..::|:   ..::|.||:                    |..||.:|
 Frog   316 H---------FLGDILIVNFE---PVMLLSASINFTRAASISCSAESRESEYNFSEDEEMN---- 364

  Fly   339 INSNQSSTSPGADQPFTVLVRAEIFHGGLTFDRNATRFVTTSPEGVEGEPLERKR---SLVVRNK 400
                   ....|..|:. .:...:..|.|..|.:...|..        :||:...   |:.:.|.
 Frog   365 -------VPEAAAAPYP-CISHNVTEGYLGLDLSNISFFM--------QPLQEPAGLWSIWLENN 413

  Fly   401 FAIPLMLFNVSLTEPIDESILEVTLVGDPRILIQPDE--SVELLRLNLLNDQVPFKSFLRIETNV 463
            .:..:.|..||:.:. .|.:|::  :...|:|..|..  :|...:::..:..:.:.:::.|.|::
 Frog   414 LSFHISLSEVSVAQG-KEGLLKI--LNFTRLLALPSGCWTVFTFKIHAKDTPLNYLTYILIGTSL 475

  Fly   464 TV-FKLPLVSCSGRLHVSTQPIVLNFRQESLEKAAYNLELDLGTVPFAEMSRDGFVILRNDNPVP 527
            .| ||:|       :|:.:....|...||       .:.:..|..|...:...|..:
 Frog   476 GVTFKIP-------VHIQSAFSKLGNMQE-------KIHVQCGEHPLIRILDAGGAL-------- 518

  Fly   528 VRITNWFFKHPKTVYSQSTFLGCRATAIGHPVSVENDTKGWHLCTEIRAGESAVFKVAIQTYEAD 592
                .|         .||..|...|..|.:.:..|                         .||
 Frog   519 ----RW---------QQSLSLSMSAWGIDYELGTE-------------------------LYE-- 543

  Fly   593 ATFGTLKVWTPYEVIRVRVKFEASVGHLEIDQEQLSFKNCFPGKMCTAVLSIRSSFTHPVHVKGI 657
                               |:          |:.||.:|.                       |.
 Frog   544 -------------------KY----------QKMLSGENV-----------------------GK 556

  Fly   658 SFALPVGLRFKDFNAKGTTIA--PQTLTKVGRIYFDPASVCRNNCYIRESTNDLAIFPSVPGGGN 720
            .:....|...:..|.|..:::  ||.:||.|.:....|:...||
 Frog   557 EYLEGSGSAQQKSNGKKHSVSFLPQLITKPGAVVNFTATALSNN--------------------- 600

  Fly   721 GNSGVINNNLLYDGVELRQRTELFRQLRRQLSSMSLTLHSEELPPLELDFSITIEWPKLVQFQPI 785
                                           |.|.:||.:..            .:|..||..|:
 Frog   601 -------------------------------SVMHVTLKNPS------------PFPVTVQLLPL 622

  Fly   786 P--PTPAIEVGQVQRQWITLTNPSQSPLLLDYFLSDPAFARRTQLSLPHEVIDVSSTSCYLTDKE 848
            .  |.|...:..:.: |..:...:       :.::...|..:.:.|..||.....:|       |
 Frog   623 SHYPNPQAALSMLSK-WYGVNEQA-------FDVTTAEFRLQKECSNMHEEPHECTT-------E 672

  Fly   849 VFSLPEAGDPILLPGGASLTIPITFSAQLPEKYCTLLHVRSNLTLYEAVWLQARAVQSQFRFGNR 913
            |..|.      ||| ..|..|.:.|:.....|..:|:.:|:|||:.:.:.::....:...|.|.|
 Frog   673 VLELQ------LLP-WESQQIGVIFTPLDYRKVTSLILIRNNLTILDMITVEGVGAREMLRMGGR 730

  Fly   914 RPGAASPLLFEMATNQFQGC----QSGNEAVVVTRSFTARNSGVIPIRIEGFLIGSLPCEDFGFK 974
            .||....|.|::..:....|    :...:.:.:|:.|...|.|.:||.|:...|....|:.|||:
 Frog   731 LPGIGGSLRFKVPESTLMDCRQQLKESKQILSITKVFKVENIGSLPITIQSMKINGYSCQGFGFE 795

  Fly   975 VMDCAGFDLGENEARKVEIAFSADFTTSAVKRSLTLLTNLTYDISYKLLAQMPAESVELCASLLV 1039
            |:||..|.|.:|.:|::.|.|..|||:|.|.|.|||::....:..:.|...:|...:.|||..:.
 Frog   796 VLDCHAFSLNQNSSREISIVFIPDFTSSWVIRELTLVSASNLEFRFTLNVTLPHHLLPLCADGVP 860

  Fly  1040 RPGWESSLKNAALVVLLASFGL--VLVAAVFDAKAIMVQQNAYDAARNKGPLQPTFNLRNIVKLQ 1102
            .|.||:|...  :.|:..||.|  |::.|...|..|::     |..:::.        ||.....
 Frog   861 GPSWENSFWK--VTVMCVSFSLLAVILIATQHAHCILI-----DFLKSRH--------RNCSISA 910

  Fly  1103 AEEAAAKAESVQQQQKVKNGQLKELRKRTVVNSTNSKSKSK-----SSWSPWSMDMNALSK---- 1158
            :.:.:::.:::..:.  ..|..|     ...:|.:|..|.|     :..:|.:...||..:
 Frog   911 SHQISSQVDTITSES--FRGSCK-----NYTDSFSSPDKGKGRGCLTVTAPQNRSQNASKRGPAT 968

  Fly  1159 --HLQKAKPKTVVSTPVTPPAASAPAAAPVPLPEAKPVKKSSTPSPQGVPISVQVRPQKKVKPTP 1221
              |.|| |.|..|...|...::|:.|::...|.:|...:.|..||..  |..........:..|.
 Frog   969 YSHSQK-KHKCSVYYSVKQKSSSSTASSVATLCDASEQQTSDMPSAN--PKDSDCNEILNLNSTE 1030

  Fly  1222 AVVLGTTKPKQEVSTPVADQHEKSLAKSSPPQQE---NISPKPNKP------------------- 1264
            :   ..|..::.:|:|.::..::..||..|..|:   |.||...||
 Frog  1031 S---RDTDNERHLSSPDSNLGKEEPAKQDPHLQQRTANESPLKEKPVLCMFPVETNLKTSESLSE 1092

  Fly  1265 ---------------------------PE---QRVLKEQNGSAKKMGKTPGR---ERERERRSKD 1296
                                       |:   |.|.|:..|:.::...|..|   |..|::.:||
 Frog  1093 PKLQPDFCDLPVPSKMSVSHLSKNLSNPQMESQTVSKKNEGNRQQTPPTLHREVLESTRKQAAKD 1157

  Fly  1297 ---QKLTNGTG------------AGVGFRKPERKQR---------QKLNFGQTTNSTSPPESPDA 1337
               :|::..|.            |.:...:|.||:.         |.:|:.:..:|....:..:.
 Frog  1158 ASNEKISRSTSREEKLCGRNDALAAIKHEEPLRKKSPIDKRDGIFQNVNWNKNRSSARKNKKKNT 1222

  Fly  1338 L--------KCISNPWETSSRVSFRDVLRTPQMAPTDNG-------------------------- 1368
            :        ..:.:.|:...|...|...|........||
 Frog  1223 VFPARGAEQNDVKHKWQEVERSDLRGPNRIKHWNSLPNGDLFKGEPKNGRFPLRGDAECYQILKK 1287

  Fly  1369 ----------------------------FDWNHATSSSDLGPIGDNRKNATP-----PMVTSLWE 1400
                                        ..|:.|:||.     || :||..|     |...|:.:
 Frog  1288 KPADKFSSDSSSDCSSSRGSVRASRGSWGSWSSASSSE-----GD-KKNGLPTRHFLPSRESMPQ 1346

  Fly  1401 -------PLSATASNSLFANTEVD---------FITPD-AIYEQREREKPQWEQRSDLVMRQQLL 1448
                   |::...|:|: .||..|         .::|. ......|:.|.:: ...|:...|.:.
 Frog  1347 SGFPAEAPIALNLSHSI-CNTSTDINAMPRYPEILSPSYTSVTDTEKSKGRY-SHEDIWSTQPVC 1409

  Fly  1449 LQQPQKLEFQLRQQEKISLLANMDPS---NWATNWSPLGYSTWPNATAGI--------------- 1495
            |  |..:.:.:  :..:|.:.. ||:   |...||:    ||.....:||
 Frog  1410 L--PNDVNYNV--EGTVSCVMR-DPAPAQNSFINWN----STCDGQFSGIYGPLELNDLAPYNEE 1465

  Fly  1496 ------GVMRP----PPGLEQSARQTHNLAQEQVSAGPASGTGAALHGESLPTQYDPFTSP---- 1546
                  |...|    |..:|...:.|.|::.....|.|        ....:|:.::|.:.|
 Frog  1466 NMNYHSGFSCPEVQNPAFIEHQCQPTWNMSAPVPPAPP--------QDPPMPSTWEPASYPYLSS 1522

  Fly  1547 -----------SSIWS 1551
                       .|||:
 Frog  1523 TRSLSPMSGLFGSIWA 1538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmem131	NP_611073.2	TMEM131_like_N	54..137	CDD:463553	31/82 (38%)
		TMEM131_like	<880..>1064	CDD:437364	58/189 (31%)
tmem131l	XP_002933525.2	TMEM131_like_N	87..170	CDD:463553	31/82 (38%)
		TMEM131_like	181..1610	CDD:437364	306/1677 (18%)