DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATPCL and SUCLG2

DIOPT Version :9

Sequence 1:	NP_001137674.2	Gene:	ATPCL / 36760	FlyBaseID:	FBgn0020236	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001171070.1	Gene:	SUCLG2 / 8801	HGNCID:	11450	Length:	440	Species:	Homo sapiens

Alignment Length:	392	Identity:	101/392 - (25%)
Similarity:	147/392 - (37%)	Gaps:	82/392 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GAATCRF---STVNSTTDWSKLAVDHPWLLTTPLVCKPDQLIKRRGKLGLI--GVKKNF------ 78
            |....||   .|.|...:.:|.      |....:|.|...|...||| |:.  |:|...
Human    53 GVRVQRFFVADTANEALEAAKR------LNAKEIVLKAQILAGGRGK-GVFNSGLKGGVHLTKDP 110

  Fly    79 ----EQVKQWIGERLNKDQ--KIGNAVGKLRNFIIEPFVPHTDAEEMYVCIYSHRAAD--TILFY 135
                :..||.||..|...|  |.|..|.|:  .:.|..   ..:.|.|:.|...|:.:  .::..
Human   111 NVVGQLAKQMIGYNLATKQTPKEGVKVNKV--MVAEAL---DISRETYLAILMDRSCNGPVLVGS 170

  Fly   136 HQGGVDIGDVDAKAVKLDVPVNSSLSLADVKSKLLKEVKDAGT-------------KERIAKFVS 187
            .||||||.:|.|.        |..|...: :..:.:.:||:..             |.:.|..::
Human   171 PQGGVDIEEVAAS--------NPELIFKE-QIDIFEGIKDSQAQRMAENLGFVGPLKSQAADQIT 226

  Fly   188 ALYTTYVDLYFTYLEINPLVVTADNLYI-LDLAAKLDSTADFICRPKWGEIDYPPPFGRDAYPEE 251
            .||..::.:..|.:|:||...|.:...: .|.....|..|:|  |.|  :|     |..|...|.
Human   227 KLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEF--RQK--DI-----FAMDDKSEN 282

  Fly   252 AYIADLDAKSGASLKLTILNRNGRIWTMVAGGGASVIYSDTICDLGGASELANYGEYSGAPSEQQ 316
            ..|.:    ..|...|..:..:|.|...|.|.|.::...|.|...||  :.||:.:..|...|.|
Human   283 EPIEN----EAAKYDLKYIGLDGNIACFVNGAGLAMATCDIIFLNGG--KPANFLDLGGGVKEAQ 341

  Fly   317 TYEYAKTILNLMTSSPKHPDGKVLITGGGIANFTNVAATFQGIITALREFQPKLVEHNVSIFVRR 381
            .|:..|    |:|:.||.....|.|.||    ..|.|....||..|.||.:.|     |.:.||.
Human   342 VYQAFK----LLTADPKVEAILVNIFGG----IVNCAIIANGITKACRELELK-----VPLVVRL 393

  Fly   382 AG 383
            .|
Human   394 EG 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPCL	NP_001137674.2	PLN02235	1..421	CDD:177879	101/392 (26%)
		ATP-grasp_4	8..208	CDD:302634	51/214 (24%)
		Citrate_bind	248..423	CDD:292732	40/136 (29%)
		PLN02522	503..1106	CDD:178137
		CoA_binding	504..613	CDD:214881
		Ligase_CoA	672..796	CDD:304578
		CCL_ACL-C	868..1105	CDD:99854
SUCLG2	NP_001171070.1	sucC	39..396	CDD:234813	101/392 (26%)
		ATP-grasp_2	39..247	CDD:285620	51/214 (24%)
		Ligase_CoA	306..>396	CDD:278948	34/105 (32%)
		Substrate binding, shared with subunit alpha. /evidence=ECO:0000255\|HAMAP-Rule:MF_03221	365..367		1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810