DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATPCL and ACLA-1

DIOPT Version :9

Sequence 1:	NP_001137674.2	Gene:	ATPCL / 36760	FlyBaseID:	FBgn0020236	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001184953.1	Gene:	ACLA-1 / 837610	AraportID:	AT1G10670	Length:	443	Species:	Arabidopsis thaliana

Alignment Length:	446	Identity:	193/446 - (43%)
Similarity:	264/446 - (59%)	Gaps:	35/446 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKAITEASGKDILNRHLN-------------------THGA-GAATCRFSTVNSTTDWSKLAV 45
            |:.|.|.|...|.::..|..                   .|.. |.:..|...:|.|||.::|..
plant     1 MARKKIREYDSKRLVKEHFKRLSGKELPIRSVQADDVFWLHSCFGFSDIRHHVINETTDLNELVE 65

  Fly    46 DHPWLLTTPLVCKPDQLIKRRGKLGLIGVKKNFEQVKQWIGERLNKDQKIGNAVGKLRNFIIEPF 110
            ..|||.:..||.|||.|..:|||.||:.:|.:|..|..::.|||.|:.::....|.:..||:|||
plant    66 KEPWLSSEKLVVKPDMLFGKRGKSGLVALKLDFADVATFVKERLGKEVEMSGCKGPITTFIVEPF 130

  Fly   111 VPHTDAEEMYVCIYSHRAADTILFYHQGGVDIGDVDAKAVKLDVPVNSSLS---LADVKSKLLKE 172
            |||.  ||.|:.:.|.|...:|.|...||::|.:...|...:.:|..:||:   .|.:.:.|..|
plant   131 VPHN--EEYYLNVVSDRLGCSISFSECGGIEIEENWDKVKTIFLPTGASLTPEICAPLVATLPLE 193

  Fly   173 VKDAGTKERIAKFVSALYTTYVDLYFTYLEINPLVVTADNLYILDLAAKLDSTADFICRPKWGEI 237
            :     |..|.:|:..::|.:.||.||:||:||..:...:.|.||:..:||.||.|....|||:|
plant   194 I-----KAEIEEFIKVIFTLFQDLDFTFLEMNPFTLVDGSPYPLDMRGELDDTAAFKNFKKWGDI 253

  Fly   238 DYPPPFGRDAYPEEAYIADLDAKSGASLKLTILNRNGRIWTMVAGGGASVIYSDTICDLGGASEL 302
            ::|.||||...|.|::|..||.|:.||||.|:||..||||||||||||||||:||:.|||.||||
plant   254 EFPLPFGRVMSPTESFIHGLDEKTSASLKFTVLNPKGRIWTMVAGGGASVIYADTVGDLGYASEL 318

  Fly   303 ANYGEYSGAPSEQQTYEYAKTILNLMTSSPKHPDGK--VLITGGGIANFTNVAATFQGIITALRE 365
            .||.||||||.|.:..:||:.:::..|:   :||||  .|:.||||||||:|||||.|||.||:|
plant   319 GNYAEYSGAPKEDEVLQYARVVIDCATA---NPDGKSRALVIGGGIANFTDVAATFNGIIRALKE 380

  Fly   366 FQPKLVEHNVSIFVRRAGPNYQEGLRKMRDFGSTLGIPLHVFGPETHMTAICGMAL 421
            .:.||....:.|||||.|||||:||.|||..|..:|:|:.|:|||..||.||..|:
plant   381 KEAKLKAARMHIFVRRGGPNYQKGLAKMRALGDDIGVPIEVYGPEATMTGICKEAI 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPCL	NP_001137674.2	PLN02235	1..421	CDD:177879	192/444 (43%)
		ATP-grasp_4	8..208	CDD:302634	70/222 (32%)
		Citrate_bind	248..423	CDD:292732	103/176 (59%)
		PLN02522	503..1106	CDD:178137
		CoA_binding	504..613	CDD:214881
		Ligase_CoA	672..796	CDD:304578
		CCL_ACL-C	868..1105	CDD:99854
ACLA-1	NP_001184953.1	PLN02235	1..443	CDD:177879	193/446 (43%)
		ATP-grasp_4	57..222	CDD:302634	62/171 (36%)
		Citrate_bind	264..438	CDD:292732	103/176 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	205	1.000	Domainoid score	I831
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101446
Panther	1	1.100	-	-	O	PTHR23118
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810