DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATPCL and ACLB-1

DIOPT Version :9

Sequence 1:	NP_001137674.2	Gene:	ATPCL / 36760	FlyBaseID:	FBgn0020236	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001326324.1	Gene:	ACLB-1 / 819845	AraportID:	AT3G06650	Length:	608	Species:	Arabidopsis thaliana

Alignment Length:	603	Identity:	325/603 - (53%)
Similarity:	433/603 - (71%)	Gaps:	1/603 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 KFFSNTTKAIVWGMQQRAVQSMLDFDFICRRDEPSVVAMVYPFTGDHKQKYYWGHKEILIPVYKK 567
            :.||..|:|:.:..:|..:|.||||||:|.|:.|||..::.| ..:..||.::|.:||.|||:..
plant     5 QLFSRNTQALFYNYKQLPIQRMLDFDFLCGRETPSVAGIINP-GSEGFQKLFFGQEEIAIPVHAA 68

  Fly   568 MSDAIHKHKEVDVMVNFASMRSAYESTLEVLEFPQIRTVAIIAEGIPENMTRKLIIEADKKGVAI 632
            :..|...|...||.:||||.|||..|::..|:.|.|:.|||||||:||:.|::||..|......|
plant    69 IEAACAAHPTADVFINFASFRSAAASSMAALKQPTIKVVAIIAEGVPESDTKQLIAYARANNKVI 133

  Fly   633 IGPATVGGVKPGCFKIGNTGGMLDNILHSKLYRPGSVAYVSRSGGMSNELNNIISKATDGVIEGI 697
            |||||||||:.|.||||:|.|.:|||:..||||||||.:||:|||||||:.|.|::.|||:.|||
plant   134 IGPATVGGVQAGAFKIGDTAGTIDNIIQCKLYRPGSVGFVSKSGGMSNEMYNTIARVTDGIYEGI 198

  Fly   698 AIGGDRYPGSTFMDHILRYQADPETKLIVLLGEVGGTEEYDVCAALKDGRITKPLVAWCIGTCAS 762
            |||||.:||||..|||||:...|:.|::|:|||:||.:||.:..|:|.|::|||:|||..||||.
plant   199 AIGGDVFPGSTLSDHILRFNNIPQIKMVVVLGELGGRDEYSLVEAMKQGKVTKPVVAWVSGTCAR 263

  Fly   763 MFTSEVQFGHAGSCANSDRETATAKNKGLRDAGAYVPDSFDTLGELIHHVYGELVKTGRVVPKEE 827
            :|.|||||||||:.:..:.|:|.|||:.|:||||.||.||:.|...|...:.:||:.|:|.|.:|
plant   264 LFKSEVQFGHAGAKSGGEMESAQAKNQALQDAGATVPTSFEALEVAIKETFDKLVEEGKVSPIKE 328

  Fly   828 VPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPISEVLSKDVGIGGVISLLWFQR 892
            |.||.:|.|.|.|.:.|.:|.|...:::|.|:||:|..|||:|:|.::.:..|:|.|||||||:|
plant   329 VTPPQIPEDLSSAIKSGKVRAPTHIISTISDDRGEEPCYAGVPMSSIIEQGYGVGDVISLLWFKR 393

  Fly   893 CLPSYVCKFFEMCLMVTADHGPAVSGAHNTIVCARAGKDLVSSVVSGLLTIGDRFGGALDGSARQ 957
            .||.|..||.|:|:|:.|||||.|||||||||.||||||||||:||||||||.|||||:|.:||.
plant   394 SLPRYCTKFIEICIMLCADHGPCVSGAHNTIVTARAGKDLVSSLVSGLLTIGPRFGGAIDDAARY 458

  Fly   958 FSEAYDTNLHPMEFVNKMRKEGKLILGIGHRVKSINNPDVRVKIIKEFVLENFPACPLLKYALEV 1022
            |.:|.|.||.|.|||..|:|:|..:.|||||:||.:|.|.||:::::|...||||...::||::|
plant   459 FKDACDRNLTPYEFVEGMKKKGIRVPGIGHRIKSRDNRDKRVELLQKFARSNFPAVKYMEYAVQV 523

  Fly  1023 EKITTNKKPNLILNVDGVIATAFVDMLRNSGSFTSEEAQEYINVGAINSLFVLGRSIGFIGHYMD 1087
            |..|.:|..||:|||||.|.:.|:|:|..||.||.:|..|.:.:|.:|.||||.||||.|||..|
plant   524 ETYTLSKANNLVLNVDGAIGSLFLDLLAGSGMFTKQEIDEIVQIGYLNGLFVLARSIGLIGHTFD 588

  Fly  1088 QKRLKQGLYRHPWDDISY 1105
            ||||||.||||||:|:.|
plant   589 QKRLKQPLYRHPWEDVLY 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPCL	NP_001137674.2	PLN02235	1..421	CDD:177879
		ATP-grasp_4	8..208	CDD:302634
		Citrate_bind	248..423	CDD:292732
		PLN02522	503..1106	CDD:178137	325/603 (54%)
		CoA_binding	504..613	CDD:214881	47/108 (44%)
		Ligase_CoA	672..796	CDD:304578	72/123 (59%)
		CCL_ACL-C	868..1105	CDD:99854	139/236 (59%)
ACLB-1	NP_001326324.1	PLN02522	1..608	CDD:178137	325/603 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	238	1.000	Domainoid score	I601
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H854
Inparanoid	1	1.050	662	1.000	Inparanoid score	I155
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D349367at2759
OrthoFinder	1	1.000	-	-		FOG0003182
OrthoInspector	1	1.000	-	-		otm3042
orthoMCL	1	0.900	-	-		OOG6_101446
Panther	1	1.100	-	-	LDO	PTHR23118
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2581
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830