DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATPCL and aclyb

DIOPT Version :9

Sequence 1:	NP_001137674.2	Gene:	ATPCL / 36760	FlyBaseID:	FBgn0020236	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	XP_001334195.4	Gene:	aclyb / 794259	ZFINID:	ZDB-GENE-090909-2	Length:	1111	Species:	Danio rerio

Alignment Length:	1117	Identity:	743/1117 - (66%)
Similarity:	891/1117 - (79%)	Gaps:	18/1117 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKAITEASGKDILNRHLNTHGAGAATCRFSTVNSTTD--WSKLAVDHPWLLTTPLVCKPDQLI 63
            ||.|||:|.:||::|.:::.|  ......|||.|..|||  |..:.||||||||..||.||||||
Zfish     1 MSVKAISERTGKELLYKYICT--TAVVRNRFSCVTVTTDTNWDCITVDHPWLLTERLVVKPDQLI 63

  Fly    64 KRRGKLGLIGVKKNFEQVKQWIGERLNKDQKIGNAVGKLRNFIIEPFVPHTDAEEMYVCIYSHRA 128
            ||||||||:.|....|.|::|:...|..:..:|||.|.|:.|:|||||||...||.|||||:.|.
Zfish    64 KRRGKLGLVAVDLKLESVQEWLKSHLMTEITVGNAKGVLKKFLIEPFVPHIQEEEFYVCIYASRE 128

  Fly   129 ADTILFYHQGGVDIGDVDAKAVKLDVPVNSSLSLADVKSKLLKEVKDAGTKERIAKFVSALYTTY 193
            ...:||:|:|||:|||||.||.:|.:.::..|....|..:||..|.| ..||.:|.|:..|:..|
Zfish   129 GSHVLFHHEGGVEIGDVDNKAQRLTLGIDEKLMEEIVTQQLLVHVPD-DKKEVLASFIVGLFNLY 192

  Fly   194 VDLYFTYLEINPLVVTADNLYILDLAAKLDSTADFICRPKWGEIDYPPPFGRDAYPEEAYIADLD 258
            .|||||||||||||||.|.:|:||:|||:||.|::||:||||::::||||||:||||||||||||
Zfish   193 EDLYFTYLEINPLVVTKDGVYVLDMAAKIDSAAEYICKPKWGDVEFPPPFGREAYPEEAYIADLD 257

  Fly   259 AKSGASLKLTILNRNGRIWTMVAGGGASVIYSDTICDLGGASELANYGEYSGAPSEQQTYEYAKT 323
            :|||||||||:||.:||||||||||||||:||||||||||..||||||||||:|||||.|:||||
Zfish   258 SKSGASLKLTVLNPSGRIWTMVAGGGASVVYSDTICDLGGVDELANYGEYSGSPSEQQMYDYAKT 322

  Fly   324 ILNLMTSSPKHPDGKVLITGGGIANFTNVAATFQGIITALREFQPKLVEHNVSIFVRRAGPNYQE 388
            ||.|||.. ||.||||||.||.|||||||||||:||:.|::::|..|.||.|:|||||.||||||
Zfish   323 ILLLMTRE-KHSDGKVLIIGGSIANFTNVAATFKGIVRAIKDYQEPLKEHEVTIFVRRGGPNYQE 386

  Fly   389 GLRKMRDFGSTLGIPLHVFGPETHMTAICGMALGKRPIPQTASVEFSTANFLL-PGGQQAQADLK 452
            |||.|.:.|.|.|||:||||.|||||||.|||||.||||....|...||:||| .....|...:.
Zfish   387 GLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPVAAHTASFLLNSSASAATPPIT 451

  Fly   453 AASDASE--ALGSGSALSPTAAKPIKLPPISADEADSAGISGAQRNGSSLNRK---FFSNTTKAI 512
            ..:..||  ......|::||..    .||:.:....|  .||.....:::..|   .||..||.|
Zfish   452 RNTSLSEHNTCSVTDAITPTTG----APPVVSTHCHS--WSGKVMLNAAVKAKPTTLFSRQTKVI 510

  Fly   513 VWGMQQRAVQSMLDFDFICRRDEPSVVAMVYPFTGDHKQKYYWGHKEILIPVYKKMSDAIHKHKE 577
            |.|:|.:|||.|||||::|.||||||||||||:|||||||:||||||||:.|||.|:||:.||.:
Zfish   511 VCGIQTQAVQGMLDFDYVCSRDEPSVVAMVYPYTGDHKQKFYWGHKEILLSVYKNMADAMKKHPD 575

  Fly   578 VDVMVNFASMRSAYESTLEVLEFPQIRTVAIIAEGIPENMTRKLIIEADKKGVAIIGPATVGGVK 642
            |||::||||:|||::||:|.|::|||||:|||||||||.:|||||..||:|||.|||||||||:|
Zfish   576 VDVLINFASLRSAFDSTMETLQYPQIRTIAIIAEGIPEALTRKLIKTADEKGVTIIGPATVGGIK 640

  Fly   643 PGCFKIGNTGGMLDNILHSKLYRPGSVAYVSRSGGMSNELNNIISKATDGVIEGIAIGGDRYPGS 707
            |||||||||||||||||.|||||||||||||.|||||||||||||..||||.||:||||||:|||
Zfish   641 PGCFKIGNTGGMLDNILASKLYRPGSVAYVSSSGGMSNELNNIISHTTDGVYEGVAIGGDRFPGS 705

  Fly   708 TFMDHILRYQADPETKLIVLLGEVGGTEEYDVCAALKDGRITKPLVAWCIGTCASMFTSEVQFGH 772
            |||||:||||..|..|:||:|||:||||||::|..:.||.||||:|.|||||||::.:|||||||
Zfish   706 TFMDHVLRYQDTPGIKMIVVLGEIGGTEEYNICQGITDGLITKPIVCWCIGTCATLLSSEVQFGH 770

  Fly   773 AGSCANSDRETATAKNKGLRDAGAYVPDSFDTLGELIHHVYGELVKTGRVVPKEEVPPPTVPMDY 837
            ||:||....|||.|||:.||:|||:||:|||.||::|..||.:||..|.:||::|||||||||||
Zfish   771 AGACATQVLETAVAKNQALREAGAFVPNSFDELGDVIKFVYDDLVTNGIIVPEQEVPPPTVPMDY 835

  Fly   838 SWARELGLIRKPASFMTSICDERGQELIYAGMPISEVLSKDVGIGGVISLLWFQRCLPSYVCKFF 902
            ||||||||||||||||||||||||||:|||||||:||..:::|:|||:.||||||.||.|.|:|.
Zfish   836 SWARELGLIRKPASFMTSICDERGQEVIYAGMPITEVFKEEMGVGGVLGLLWFQRRLPRYACQFI 900

  Fly   903 EMCLMVTADHGPAVSGAHNTIVCARAGKDLVSSVVSGLLTIGDRFGGALDGSARQFSEAYDTNLH 967
            |||||||||||||||||||||||||||||||||:.|||||||||||||||.:|:|||:|:|:.|.
Zfish   901 EMCLMVTADHGPAVSGAHNTIVCARAGKDLVSSLTSGLLTIGDRFGGALDAAAKQFSKAFDSGLL 965

  Fly   968 PMEFVNKMRKEGKLILGIGHRVKSINNPDVRVKIIKEFVLENFPACPLLKYALEVEKITTNKKPN 1032
            ||||||||:|:|.||:|||||||||||||:||:|:|:||.::||:..||.||||||||||:||||
Zfish   966 PMEFVNKMKKDGVLIMGIGHRVKSINNPDMRVQILKDFVKQHFPSTQLLDYALEVEKITTSKKPN 1030

  Fly  1033 LILNVDGVIATAFVDMLRNSGSFTSEEAQEYINVGAINSLFVLGRSIGFIGHYMDQKRLKQGLYR 1097
            ||||:||.|..||||:||..|.||.:||.|::::|.:|.:|||||||||||||:|||||||||||
Zfish  1031 LILNIDGFIGVAFVDLLRTCGGFTRDEADEFVDIGTLNGIFVLGRSIGFIGHYLDQKRLKQGLYR 1095

  Fly  1098 HPWDDISYVIPE 1109
            |||||||||:||
Zfish  1096 HPWDDISYVLPE 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPCL	NP_001137674.2	PLN02235	1..421	CDD:177879	265/421 (63%)
		ATP-grasp_4	8..208	CDD:302634	101/201 (50%)
		Citrate_bind	248..423	CDD:292732	135/174 (78%)
		PLN02522	503..1106	CDD:178137	450/605 (74%)
		CoA_binding	504..613	CDD:214881	76/108 (70%)
		Ligase_CoA	672..796	CDD:304578	87/123 (71%)
		CCL_ACL-C	868..1105	CDD:99854	176/236 (75%)
aclyb	XP_001334195.4	PLN02235	1..419	CDD:177879	265/421 (63%)
		ATP-grasp_4	<55..207	CDD:302634	80/152 (53%)
		Citrate_bind	247..421	CDD:292732	135/174 (78%)
		PLN02522	501..1104	CDD:178137	449/602 (75%)
		NADB_Rossmann	505..610	CDD:304358	73/104 (70%)
		Ligase_CoA	670..795	CDD:304578	88/124 (71%)
		CCL_ACL-C	866..1103	CDD:99854	176/236 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574680
Domainoid	1	1.000	314	1.000	Domainoid score	I1264
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1547	1.000	Inparanoid score	I93
OMA	1	1.010	-	-		QHG59168
OrthoDB	1	1.010	-	-		D349367at2759
OrthoFinder	1	1.000	-	-		FOG0003182
OrthoInspector	1	1.000	-	-		otm25141
orthoMCL	1	0.900	-	-		OOG6_101446
Panther	1	1.100	-	-	O	PTHR23118
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2581
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770