DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATPCL and ACLY

DIOPT Version :9

Sequence 1:NP_001137674.2 Gene:ATPCL / 36760 FlyBaseID:FBgn0020236 Length:1112 Species:Drosophila melanogaster
Sequence 2:NP_001290203.1 Gene:ACLY / 47 HGNCID:115 Length:1155 Species:Homo sapiens


Alignment Length:1118 Identity:771/1118 - (68%)
Similarity:906/1118 - (81%) Gaps:30/1118 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSAKAITEASGKDILNRHLNTHGAGAATCRFSTVNSTTDWSKLAVDHPWLLTTPLVCKPDQLIKR 65
            ||||||:|.:||::|.:.:.|..|.....:::.|...|||::|..||||||:..||.||||||||
Human    55 MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKR 119

  Fly    66 RGKLGLIGVKKNFEQVKQWIGERLNKDQKIGNAVGKLRNFIIEPFVPHTDAEEMYVCIYSHRAAD 130
            ||||||:||....:.||.|:..||.::..:|.|.|.|:||:|||||||:.|||.|||||:.|..|
Human   120 RGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGD 184

  Fly   131 TILFYHQGGVDIGDVDAKAVKLDVPVNSSLSLADVKSKLLKEVKDAGTKERIAKFVSALYTTYVD 195
            .:||:|:||||:|||||||.||.|.|:..|:..|:|..||....: ..||.:|.|:|.|:..|.|
Human   185 YVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPE-DKKEILASFISGLFNFYED 248

  Fly   196 LYFTYLEINPLVVTADNLYILDLAAKLDSTADFICRPKWGEIDYPPPFGRDAYPEEAYIADLDAK 260
            ||||||||||||||.|.:|:||||||:|:|||:||:.|||:|::||||||:||||||||||||||
Human   249 LYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAK 313

  Fly   261 SGASLKLTILNRNGRIWTMVAGGGASVIYSDTICDLGGASELANYGEYSGAPSEQQTYEYAKTIL 325
            ||||||||:||..||||||||||||||:||||||||||.:||||||||||||||||||:||||||
Human   314 SGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTIL 378

  Fly   326 NLMTSSPKHPDGKVLITGGGIANFTNVAATFQGIITALREFQPKLVEHNVSIFVRRAGPNYQEGL 390
            :|||.. ||||||:||.||.|||||||||||:||:.|:|::|..|.||.|:|||||.||||||||
Human   379 SLMTRE-KHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGL 442

  Fly   391 RKMRDFGSTLGIPLHVFGPETHMTAICGMALGKRPIPQTASVEFSTANFLLPGGQQAQADLKAAS 455
            |.|.:.|.|.|||:||||.|||||||.|||||.||||........||||||.             
Human   443 RVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLN------------- 494

  Fly   456 DASEALGSGSALSPTAAKPIKLPPISADE------ADSAGISGAQRNGSSLNRK---FFSNTTKA 511
                  .|||..:|..::........|||      |..|....:..:..||..|   .||..|||
Human   495 ------ASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRHTKA 553

  Fly   512 IVWGMQQRAVQSMLDFDFICRRDEPSVVAMVYPFTGDHKQKYYWGHKEILIPVYKKMSDAIHKHK 576
            ||||||.||||.|||||::|.||||||.|||||||||||||:|||||||||||:|.|:||:.||.
Human   554 IVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHP 618

  Fly   577 EVDVMVNFASMRSAYESTLEVLEFPQIRTVAIIAEGIPENMTRKLIIEADKKGVAIIGPATVGGV 641
            ||||::||||:||||:||:|.:.:.||||:|||||||||.:|||||.:||:|||.|||||||||:
Human   619 EVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGI 683

  Fly   642 KPGCFKIGNTGGMLDNILHSKLYRPGSVAYVSRSGGMSNELNNIISKATDGVIEGIAIGGDRYPG 706
            ||||||||||||||||||.|||||||||||||||||||||||||||:.||||.||:|||||||||
Human   684 KPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPG 748

  Fly   707 STFMDHILRYQADPETKLIVLLGEVGGTEEYDVCAALKDGRITKPLVAWCIGTCASMFTSEVQFG 771
            ||||||:||||..|..|:||:|||:||||||.:|..:|:||:|||:|.|||||||:||:||||||
Human   749 STFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFG 813

  Fly   772 HAGSCANSDRETATAKNKGLRDAGAYVPDSFDTLGELIHHVYGELVKTGRVVPKEEVPPPTVPMD 836
            |||:|||...|||.|||:.|::||.:||.|||.|||:|..||.:||..|.:||.:||||||||||
Human   814 HAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMD 878

  Fly   837 YSWARELGLIRKPASFMTSICDERGQELIYAGMPISEVLSKDVGIGGVISLLWFQRCLPSYVCKF 901
            |||||||||||||||||||||||||||||||||||:||..:::|||||:.|||||:.||.|.|:|
Human   879 YSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQF 943

  Fly   902 FEMCLMVTADHGPAVSGAHNTIVCARAGKDLVSSVVSGLLTIGDRFGGALDGSARQFSEAYDTNL 966
            .|||||||||||||||||||||:|||||||||||:.|||||||||||||||.:|:.||:|:|:.:
Human   944 IEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGI 1008

  Fly   967 HPMEFVNKMRKEGKLILGIGHRVKSINNPDVRVKIIKEFVLENFPACPLLKYALEVEKITTNKKP 1031
            .||||||||:||||||:|||||||||||||:||:|:|::|.::|||.|||.||||||||||:|||
Human  1009 IPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKP 1073

  Fly  1032 NLILNVDGVIATAFVDMLRNSGSFTSEEAQEYINVGAINSLFVLGRSIGFIGHYMDQKRLKQGLY 1096
            ||||||||:|..||||||||.||||.|||.|||::||:|.:||||||:||||||:||||||||||
Human  1074 NLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLY 1138

  Fly  1097 RHPWDDISYVIPE 1109
            ||||||||||:||
Human  1139 RHPWDDISYVLPE 1151

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATPCLNP_001137674.2 PLN02235 1..421 CDD:177879 276/419 (66%)
ATP-grasp_4 8..208 CDD:302634 105/199 (53%)
Citrate_bind 248..423 CDD:292732 139/174 (80%)
PLN02522 503..1106 CDD:178137 467/605 (77%)
CoA_binding 504..613 CDD:214881 81/108 (75%)
Ligase_CoA 672..796 CDD:304578 91/123 (74%)
CCL_ACL-C 868..1105 CDD:99854 183/236 (78%)
ACLYNP_001290203.1 PLN02235 55..473 CDD:177879 276/419 (66%)
ATP-grasp_4 60..261 CDD:302634 106/201 (53%)
Citrate_bind 301..475 CDD:292732 139/174 (80%)
PLN02522 545..1148 CDD:178137 466/602 (77%)
CoA_binding 546..655 CDD:214881 81/108 (75%)
Ligase_CoA 714..839 CDD:304578 92/124 (74%)
CCL_ACL-C 910..1147 CDD:99854 183/236 (78%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141675
Domainoid 1 1.000 325 1.000 Domainoid score I1193
eggNOG 1 0.900 - - E1_COG0045
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H854
Inparanoid 1 1.050 1572 1.000 Inparanoid score I88
Isobase 1 0.950 - 0 Normalized mean entropy S1505
OMA 1 1.010 - - QHG59168
OrthoDB 1 1.010 - - D349367at2759
OrthoFinder 1 1.000 - - FOG0003182
OrthoInspector 1 1.000 - - oto88874
orthoMCL 1 0.900 - - OOG6_101446
Panther 1 1.100 - - LDO PTHR23118
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R13
SonicParanoid 1 1.000 - - X2581
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1817.750

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