DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATPCL and aclya

DIOPT Version :9

Sequence 1:	NP_001137674.2	Gene:	ATPCL / 36760	FlyBaseID:	FBgn0020236	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001002649.2	Gene:	aclya / 436922	ZFINID:	ZDB-GENE-031113-1	Length:	1092	Species:	Danio rerio

Alignment Length:	1113	Identity:	754/1113 - (67%)
Similarity:	896/1113 - (80%)	Gaps:	29/1113 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKAITEASGKDILNRHLNTHGAGAATCRFSTVNSTTDWSKLAVDHPWLLTTPLVCKPDQLIKR 65
            ||||||:|.:||:.|.:|:.|..:.....|::.|.:.|||.:|..|||||||..||.||||||||
Zfish     1 MSAKAISEQTGKEFLYKHICTSASVQNRFRYANVTAETDWERLVQDHPWLLTERLVVKPDQLIKR 65

  Fly    66 RGKLGLIGVKKNFEQVKQWIGERLNKDQKIGNAVGKLRNFIIEPFVPHTDAEEMYVCIYSHRAAD 130
            ||||||:||..:...||:|:..||.::..:|.|.|.|:||:|||||.|...||.|||||:.|..|
Zfish    66 RGKLGLVGVNLDLNGVKEWLKSRLMQETMVGKAKGILKNFLIEPFVAHKQEEEFYVCIYATREGD 130

  Fly   131 TILFYHQGGVDIGDVDAKAVKLDVPVNSSLSLADVKSKLLKEVKDAGTKERIAKFVSALYTTYVD 195
            .:||:|:||||:||||:||:||.|.|:..:|...|||:||... .|..||.::.|:..|:..|.|
Zfish   131 YMLFHHEGGVDVGDVDSKALKLLVGVDEKISADTVKSQLLTHA-PADKKEILSSFLVGLFNLYED 194

  Fly   196 LYFTYLEINPLVVTADNLYILDLAAKLDSTADFICRPKWGEIDYPPPFGRDAYPEEAYIADLDAK 260
            ||||||||||||||.|.:|:||:|||:|:|||::|:.|||::::||||||:||||||||||||||
Zfish   195 LYFTYLEINPLVVTKDGVYVLDMAAKIDATADYLCKAKWGDVEFPPPFGREAYPEEAYIADLDAK 259

  Fly   261 SGASLKLTILNRNGRIWTMVAGGGASVIYSDTICDLGGASELANYGEYSGAPSEQQTYEYAKTIL 325
            ||||||||:||..||||||||||||||:||||||||||.:||||||||||||||||||:||||||
Zfish   260 SGASLKLTLLNPRGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTIL 324

  Fly   326 NLMTSSPKHPDGKVLITGGGIANFTNVAATFQGIITALREFQPKLVEHNVSIFVRRAGPNYQEGL 390
            :|||.. |||||||||.||.|||||||||||:||:.|.:::|..|.||.|:|||||.||||||||
Zfish   325 SLMTRE-KHPDGKVLIIGGSIANFTNVAATFKGIVRAFKDYQDPLKEHEVTIFVRRGGPNYQEGL 388

  Fly   391 RKMRDFGSTLGIPLHVFGPETHMTAICGMALGKRPIPQTASVEFSTANFLL--PGGQQAQADLKA 453
            |.|.:.|.|.|||:||||.|||||||.|||||.|||.........||||||  .||....|..::
Zfish   389 RVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIATQPRGAAHTANFLLNASGGTTTPASSRS 453

  Fly   454 ASDASEALG--SGSALSPTAAKPIKLPPISADEADSAGISGAQRNGSSLNRKFFSNTTKAIVWGM 516
            ||.:....|  |.|.|...|.    |||                   :.:...|||.||:|||||
Zfish   454 ASFSEVRTGAESSSGLKSRAG----LPP-------------------AKSTTLFSNHTKSIVWGM 495

  Fly   517 QQRAVQSMLDFDFICRRDEPSVVAMVYPFTGDHKQKYYWGHKEILIPVYKKMSDAIHKHKEVDVM 581
            |.||||.|||||::|.|.||||.|||||||||||||:||||||||:||||.|:||:.||.||||:
Zfish   496 QTRAVQGMLDFDYVCSRQEPSVAAMVYPFTGDHKQKFYWGHKEILLPVYKNMADAMKKHPEVDVL 560

  Fly   582 VNFASMRSAYESTLEVLEFPQIRTVAIIAEGIPENMTRKLIIEADKKGVAIIGPATVGGVKPGCF 646
            ::|||:||||:||:|.::||||.|:|||||||||.:|||:|..||:||:.|||||||||:|||||
Zfish   561 ISFASLRSAYDSTIETMQFPQIHTIAIIAEGIPEALTRKIIKMADEKGITIIGPATVGGIKPGCF 625

  Fly   647 KIGNTGGMLDNILHSKLYRPGSVAYVSRSGGMSNELNNIISKATDGVIEGIAIGGDRYPGSTFMD 711
            |||||||||||||.|||||||||||||||||||||||||||:.||||.||:||||||||||.|:|
Zfish   626 KIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSVFID 690

  Fly   712 HILRYQADPETKLIVLLGEVGGTEEYDVCAALKDGRITKPLVAWCIGTCASMFTSEVQFGHAGSC 776
            |:||||..|..|:||:|||:||.|||.:|.|:|:||||||:|.|||||||::|:|||||||||:|
Zfish   691 HVLRYQDTPGVKMIVVLGEIGGNEEYKICNAIKEGRITKPVVCWCIGTCATLFSSEVQFGHAGAC 755

  Fly   777 ANSDRETATAKNKGLRDAGAYVPDSFDTLGELIHHVYGELVKTGRVVPKEEVPPPTVPMDYSWAR 841
            ||...|||.||||.|.:|||:||.|||.||::|..||..||..|.:||.:|:|||||||||||||
Zfish   756 ANQASETAVAKNKALEEAGAFVPKSFDELGDVIKSVYDNLVAKGVIVPAKELPPPTVPMDYSWAR 820

  Fly   842 ELGLIRKPASFMTSICDERGQELIYAGMPISEVLSKDVGIGGVISLLWFQRCLPSYVCKFFEMCL 906
            ||||||||||||||||||||||||||||||:||...::|:||.:.||||||.||.|.|:|.||||
Zfish   821 ELGLIRKPASFMTSICDERGQELIYAGMPITEVFKSEIGLGGTLGLLWFQRRLPRYACQFIEMCL 885

  Fly   907 MVTADHGPAVSGAHNTIVCARAGKDLVSSVVSGLLTIGDRFGGALDGSARQFSEAYDTNLHPMEF 971
            ||||||||||||||||||||||||||:||:.|||||||||||||||.:|:|||:|:|:.:.||||
Zfish   886 MVTADHGPAVSGAHNTIVCARAGKDLISSLTSGLLTIGDRFGGALDAAAKQFSKAFDSGMLPMEF 950

  Fly   972 VNKMRKEGKLILGIGHRVKSINNPDVRVKIIKEFVLENFPACPLLKYALEVEKITTNKKPNLILN 1036
            ||||:|:||||:|||||||||||||:||:|:|:||.::|||..||.||||||||||:||||||||
Zfish   951 VNKMKKDGKLIMGIGHRVKSINNPDMRVQILKDFVKQHFPATQLLDYALEVEKITTSKKPNLILN 1015

  Fly  1037 VDGVIATAFVDMLRNSGSFTSEEAQEYINVGAINSLFVLGRSIGFIGHYMDQKRLKQGLYRHPWD 1101
            |||.|..:|||:||..|.||.:||.|::.:||:|.:||||||:||||||:|||||||||||||||
Zfish  1016 VDGFIGVSFVDLLRTCGGFTRDEADEFVEIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWD 1080

  Fly  1102 DISYVIPE 1109
            |||||:||
Zfish  1081 DISYVLPE 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPCL	NP_001137674.2	PLN02235	1..421	CDD:177879	272/419 (65%)
		ATP-grasp_4	8..208	CDD:302634	104/199 (52%)
		Citrate_bind	248..423	CDD:292732	139/174 (80%)
		PLN02522	503..1106	CDD:178137	453/602 (75%)
		CoA_binding	504..613	CDD:214881	80/108 (74%)
		Ligase_CoA	672..796	CDD:304578	90/123 (73%)
		CCL_ACL-C	868..1105	CDD:99854	175/236 (74%)
aclya	NP_001002649.2	SucC	1..419	CDD:330533	272/419 (65%)
aclya	NP_001002649.2	Ligase_CoA	482..1085	CDD:330947	453/602 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574679
Domainoid	1	1.000	314	1.000	Domainoid score	I1264
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H854
Inparanoid	1	1.050	1547	1.000	Inparanoid score	I93
OMA	1	1.010	-	-		QHG59168
OrthoDB	1	1.010	-	-		D349367at2759
OrthoFinder	1	1.000	-	-		FOG0003182
OrthoInspector	1	1.000	-	-		otm25141
orthoMCL	1	0.900	-	-		OOG6_101446
Panther	1	1.100	-	-	O	PTHR23118
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R13
SonicParanoid	1	1.000	-	-		X2581
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940