DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATPCL and sucla2

DIOPT Version :9

Sequence 1:	NP_001137674.2	Gene:	ATPCL / 36760	FlyBaseID:	FBgn0020236	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_998191.1	Gene:	sucla2 / 406299	ZFINID:	ZDB-GENE-040426-1963	Length:	466	Species:	Danio rerio

Alignment Length:	381	Identity:	95/381 - (24%)
Similarity:	152/381 - (39%)	Gaps:	77/381 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VNSTTDWSKLAVDHPWLLTTPLVCKPDQLIKRRGK-------LGLIGVKKNFEQVK----QWIGE 87
            |.||.|.:..|...  :.:..||.|...|...|||       .|.:.:..:.|:.:    :.||:
Zfish    79 VASTPDEAYTAAKQ--IGSKDLVIKAQVLAGGRGKGTFEGGLKGGVRIVYSPEEARDISSKMIGK 141

  Fly    88 RLNKDQKIGNAVGKLRN--FIIEPFVPHTDAEEMYVCIYSHRA--ADTILFYHQGGVDIGDVDAK 148
            :|...| .|.| |::.|  |:.|...|.   .|.|..|...|:  ...::...||||:|.||.|:
Zfish   142 KLFTKQ-TGEA-GRICNQVFVCERRYPR---REYYFAITMERSYQGPVLIGSSQGGVNIEDVAAE 201

  Fly   149 ----AVKLDVPVNSSLSLADVKSKLLKEVKDAGTKERI----AKFVSALYTTYVDLYFTYLEINP 205
                .||..:.:...:.:    .:.:|..:..|....:    |:.:..||..::....:.:||||
Zfish   202 NPDAIVKEPIDIVEGIKM----DQAIKVAEKMGFPPALINEAAENMLKLYDVFIKYDASMVEINP 262

  Fly   206 LVVTADNLYI-LDLAAKLDSTADFICRPK-------WGEIDYPPPFGRDAYPEEAYIADLDAKSG 262
            :|..:..:.: :|.....||.|.:  |.|       |.:        .||...:|..|||:
Zfish   263 MVEDSSGIVMCMDAKINFDSNAAY--RQKKVFDMRDWSQ--------EDARDRQAAKADLN---- 313

  Fly   263 ASLKLTILNRNGRIWTMVAGGGASVIYSDTICDLGGASELANYGEYSGAPSEQQTYEYAKTILNL 327
                  .:..:|.|..:|.|.|.::...|.|...||..  ||:.:..|..:.||..|..|.|
Zfish   314 ------YIGLDGTIGCLVNGAGLAMATMDIIKLHGGTP--ANFLDVGGGATAQQVTEAFKLI--- 367

  Fly   328 MTSSPKHPDGKVLITGGGIANFTNVAATFQGIITALREFQPKLVEHNVSIFVRRAG 383
              :|.|.....::...|||.....:|   ||||.|:.:...|     :.|.||..|
Zfish   368 --TSDKKVQAILVNIFGGIMRCDVIA---QGIIMAVTDLDLK-----IPIVVRLQG 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPCL	NP_001137674.2	PLN02235	1..421	CDD:177879	95/381 (25%)
		ATP-grasp_4	8..208	CDD:302634	48/196 (24%)
		Citrate_bind	248..423	CDD:292732	37/136 (27%)
		PLN02522	503..1106	CDD:178137
		CoA_binding	504..613	CDD:214881
		Ligase_CoA	672..796	CDD:304578
		CCL_ACL-C	868..1105	CDD:99854
sucla2	NP_998191.1	sucC	58..448	CDD:234813	95/381 (25%)
		ATP-grasp_2	58..265	CDD:285620	48/196 (24%)
		Ligase_CoA	324..444	CDD:278948	31/105 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810