DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATPCL and Suclg2

DIOPT Version :9

Sequence 1:	NP_001137674.2	Gene:	ATPCL / 36760	FlyBaseID:	FBgn0020236	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001094220.1	Gene:	Suclg2 / 362404	RGDID:	1305008	Length:	434	Species:	Rattus norvegicus

Alignment Length:	441	Identity:	108/441 - (24%)
Similarity:	160/441 - (36%)	Gaps:	110/441 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ITEASGKDILNRHLNTHGAGAATCRF---STVNSTTDWSKLAVDHPWLLTTPLVCKPDQLIKRRG 67
            :.|...|.:::.|      |....||   ||.....:.:|.      |....:|.|...|...||
  Rat    42 LQEYQSKKLMSEH------GVRVQRFFVASTAKEAQEAAKR------LNAKEIVLKAQILAGGRG 94

  Fly    68 K----LGLIGVKKNFEQVKQWIGERLNKDQKIGNAVGKLRNFII--EPFVPHTDAE--------- 117
            |    .||.|            |..|.||.|:   ||:|...:|  ......|..|
  Rat    95 KGVFDSGLKG------------GVHLTKDPKV---VGQLAQQMIGYNLATKQTPKEGVKVNKVMV 144

  Fly   118 --------EMYVCIYSHRA--ADTILFYHQGGVDIGDVDAKAVKLDVPVNSSLSLADVKSKLLKE 172
                    |.|:.|...|:  ...::...||||||.:|.|.:.:|         :...:..:.:.
  Rat   145 AEALDISRETYLAILMDRSHNGPVLVGSPQGGVDIEEVAASSPEL---------IFKEQIDIFEG 200

  Fly   173 VKDA-------------GTKERIAKFVSALYTTYVDLYFTYLEINPLVVTADNLYI-LDLAAKLD 223
            :||:             ..|.:.|..:..||..::.:..|.:|:||...|.:...: .|.....|
  Rat   201 IKDSQAQRMAENLGFLGSLKNQAADQIKKLYHLFLKIDATQVEVNPFGETPEGQVVCFDAKINFD 265

  Fly   224 STADFICRPKWGEIDYPPPFGRDAYPEEAYIADLDAKSGASLKLTILNRNGRIWTMVAGGGASVI 288
            ..|:|  |.|  :|     |..|...|...|.:    ..|...|..:..:|.|...|.|.|.::.
  Rat   266 DNAEF--RQK--DI-----FAMDDKSENEPIEN----EAARYDLKYIGLDGNIACFVNGAGLAMA 317

  Fly   289 YSDTICDLGGASELANYGEYSGAPSEQQTYEYAKTILNLMTSSPKHPDGKVLITGGGIANFTNVA 353
            ..|.|...||  :.||:.:..|...|.|.|:..|    |:||.||.....|.|.||    ..|.|
  Rat   318 TCDIIFLNGG--KPANFLDLGGGVKESQVYQAFK----LLTSDPKVEAILVNIFGG----IVNCA 372

  Fly   354 ATFQGIITALREFQPKLVEHNVSIFVRRAGPNYQEGLRKMRDFGSTLGIPL 404
            ....||..|.:|.:.|     |.:.||..|.|.||....::    :.|:|:
  Rat   373 IIANGITKACQELELK-----VPLVVRLEGTNVQEAQNILK----SSGLPI 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPCL	NP_001137674.2	PLN02235	1..421	CDD:177879	108/441 (24%)
		ATP-grasp_4	8..208	CDD:302634	53/240 (22%)
		Citrate_bind	248..423	CDD:292732	45/157 (29%)
		PLN02522	503..1106	CDD:178137
		CoA_binding	504..613	CDD:214881
		Ligase_CoA	672..796	CDD:304578
		CCL_ACL-C	868..1105	CDD:99854
Suclg2	NP_001094220.1	sucC	41..422	CDD:234813	108/441 (24%)
		ATP-grasp_2	41..249	CDD:285620	53/242 (22%)
		Ligase_CoA	308..422	CDD:278948	39/126 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810