DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATPCL and Sucla2

DIOPT Version :9

Sequence 1:	NP_001137674.2	Gene:	ATPCL / 36760	FlyBaseID:	FBgn0020236	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_001101857.2	Gene:	Sucla2 / 361071	RGDID:	1309397	Length:	465	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	97/373 - (26%)
Similarity:	148/373 - (39%)	Gaps:	73/373 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LVCKPDQLIKRRGK----LGLI-GVKKNF--EQVK----QWIGERLNKDQKIGNAVGKLRN--FI 106
            :|.|...|...|||    .||. |||..|  |:.|    |.||::|...|.  .|.|::.|  .:
  Rat    97 VVIKAQVLAGGRGKGTFTSGLKGGVKIVFSPEEAKAVSSQMIGQKLITKQT--GAKGRICNQVLV 159

  Fly   107 IEPFVPHTDAEEMYVCIYSHRA--ADTILFYHQGGVDIGDVDAK----AVKLDVPVNSSLSLADV 165
            .|...|.   .|.|..|...|:  ...::...||||:|.||.|:    .||..|.:...:.
  Rat   160 CERKYPR---REYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPEAIVKEPVDIIEGVK---- 217

  Fly   166 KSKLLKEVKDAGTKERI----AKFVSALYTTYVDLYFTYLEINPLVVTADNLYILDLAAKLDSTA 226
            |.:.:...|..|....|    |:.:..||..::....|.:||||:|..||. .:|.:.||::..:
  Rat   218 KEQAVTLAKKMGFPSNIVDSAAENMIKLYNLFLKYDATMVEINPMVEDADG-KVLCMDAKINFDS 281

  Fly   227 DFICRPK-------WGEIDYPPPFGRDAYPEEAYIADLDAKSGASLKLTILNRNGRIWTMVAGGG 284
            :...|.|       |.:.|     .||             |..|...:..:..:|.|..:|.|.|
  Rat   282 NSAYRQKKIFALQDWSQED-----ERD-------------KDAADADINYIGLDGNIGCLVNGAG 328

  Fly   285 ASVIYSDTICDLGGASELANYGEYSGAPSEQQTYEYAKTILNLMTSSPKHPDGKVLITGGGIANF 349
            .::...|.|...||..  ||:.:..|..:..|..|..|.|     :|.|.....::...|||...
  Rat   329 LAMATMDIIKLHGGTP--ANFLDVGGGATVHQVTEAFKLI-----TSDKRVQAILVNIFGGIMRC 386

  Fly   350 TNVAATFQGIITALREFQPKLVEHNVSIFVRRAGPNYQEGLRKMRDFG 397
            ..:|   |||:.|:::     :|..:.:.||..|....:....:.|.|
  Rat   387 DIIA---QGIVMAVKD-----LEIRIPVVVRLQGTRVDDAKALIADSG 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPCL	NP_001137674.2	PLN02235	1..421	CDD:177879	97/373 (26%)
		ATP-grasp_4	8..208	CDD:302634	51/175 (29%)
		Citrate_bind	248..423	CDD:292732	34/150 (23%)
		PLN02522	503..1106	CDD:178137
		CoA_binding	504..613	CDD:214881
		Ligase_CoA	672..796	CDD:304578
		CCL_ACL-C	868..1105	CDD:99854
Sucla2	NP_001101857.2	sucC	57..447	CDD:234813	97/373 (26%)
		ATP-grasp_2	57..264	CDD:285620	51/175 (29%)
		Ligase_CoA	323..443	CDD:278948	30/119 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810