DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATPCL and Sucla2

DIOPT Version :9

Sequence 1:	NP_001137674.2	Gene:	ATPCL / 36760	FlyBaseID:	FBgn0020236	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	XP_006518820.1	Gene:	Sucla2 / 20916	MGIID:	1306775	Length:	500	Species:	Mus musculus

Alignment Length:	375	Identity:	95/375 - (25%)
Similarity:	150/375 - (40%)	Gaps:	77/375 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LVCKPDQLIKRRGK----LGLI-GVKKNF--EQVK----QWIGERLNKDQKIGNAVGKLRN--FI 106
            :|.|...|...|||    .||. |||..|  |:.|    |.||::|...|.  ...|::.|  .:
Mouse   132 VVIKAQVLAGGRGKGTFTSGLKGGVKIVFSPEEAKAVSSQMIGQKLITKQT--GEKGRICNQVLV 194

  Fly   107 IEPFVPHTDAEEMYVCIYSHRA--ADTILFYHQGGVDIGDVDAK----AVKLDVPV------NSS 159
            .|...|.   .|.|..|...|:  ...::...||||:|.||.|:    .||..:.:      ..:
Mouse   195 CERKYPR---REYYFAITMERSFQGPVLIGSAQGGVNIEDVAAENPEAIVKEPIDIVEGIKKEQA 256

  Fly   160 LSLADVKSKLLKEVKDAGTKERIAKFVSALYTTYVDLYFTYLEINPLVVTADNLYILDLAAKLDS 224
            ::||. |......:.|:..:..|     .||..::....|.:||||:|..:|. .:|.:.||::.
Mouse   257 VTLAQ-KMGFPSNIVDSAAENMI-----KLYNLFLKYDATMVEINPMVEDSDG-KVLCMDAKINF 314

  Fly   225 TADFICRPK-------WGEIDYPPPFGRDAYPEEAYIADLDAKSGASLKLTILNRNGRIWTMVAG 282
            .::...|.|       |.:.|     .||             |..|:..:..:..:|.|..:|.|
Mouse   315 DSNSAYRQKKIFDLQDWSQED-----ERD-------------KEAANADINYIGLDGSIGCLVNG 361

  Fly   283 GGASVIYSDTICDLGGASELANYGEYSGAPSEQQTYEYAKTILNLMTSSPKHPDGKVLITGGGIA 347
            .|.::...|.|...||..  ||:.:..|..:.||..|..|.|     :|.|.....::...|||.
Mouse   362 AGLAMATMDIIKLHGGTP--ANFLDVGGGATVQQVTEAFKLI-----TSDKKVQAILVNIFGGIM 419

  Fly   348 NFTNVAATFQGIITALREFQPKLVEHNVSIFVRRAGPNYQEGLRKMRDFG 397
            ....:|   |||:.|:::     :|..:.:.||..|....:....:.|.|
Mouse   420 RCDVIA---QGIVMAVKD-----LEIRIPVVVRLQGTRVDDAKALIADSG 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPCL	NP_001137674.2	PLN02235	1..421	CDD:177879	95/375 (25%)
		ATP-grasp_4	8..208	CDD:302634	49/177 (28%)
		Citrate_bind	248..423	CDD:292732	35/150 (23%)
		PLN02522	503..1106	CDD:178137
		CoA_binding	504..613	CDD:214881
		Ligase_CoA	672..796	CDD:304578
		CCL_ACL-C	868..1105	CDD:99854
Sucla2	XP_006518820.1	sucC	92..482	CDD:234813	95/375 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810