DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATPCL and acly-2

DIOPT Version :9

Sequence 1:	NP_001137674.2	Gene:	ATPCL / 36760	FlyBaseID:	FBgn0020236	Length:	1112	Species:	Drosophila melanogaster
Sequence 2:	NP_506267.1	Gene:	acly-2 / 179795	WormBaseID:	WBGene00007150	Length:	1099	Species:	Caenorhabditis elegans

Alignment Length:	1130	Identity:	698/1130 - (61%)
Similarity:	832/1130 - (73%)	Gaps:	53/1130 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKAITEASGKDILNRHLNTHGAGAATCRFSTVNSTTDWSKLAVDHPWLL-TTPLVCKPDQLIK 64
            |||||::|.|||::|.::..:.|..:|...|. |.:...:|.:|..:.||. ....|.|||||||
Worm     1 MSAKAVSELSGKEVLYKYFESTGIVSAPHAFH-VKAGDKFSDVAAKYEWLAQDNKGVIKPDQLIK 64

  Fly    65 RRGKLGL--IGVKKNFEQVKQWIGERLNKDQKIGNAVGKLRNFIIEPFVPHTDAEEMYVCIYSHR 127
            |||||||  ||..|..|   .|.|:..|...|:|...|:|..||:|||..||:.||||:.|||.|
Worm    65 RRGKLGLVKIGSPKELE---AWFGKTANSYVKVGQTEGRLHTFIVEPFCAHTENEEMYIAIYSER 126

  Fly   128 AADTILFYHQGGVDIGDVDAKAVKLDVPV---NSSLSLADVKSKLLKEVKDAGTKERIAKFVSAL 189
            ..|.|:||.|||||||||:.||..:.|||   ::::|:::.:..:|  :.....|:.|.|||.:|
Worm   127 CRDVIMFYEQGGVDIGDVEEKARSVHVPVQLDDNAMSISERELGVL--LGPCSDKDDIRKFVRSL 189

  Fly   190 YTTYVDLYFTYLEINPLVVTADNLYILDLAAKLDSTADFICRPKWG----------EIDYPPPFG 244
            |..|..|:||||||||.|:|...::|||||||||.||.|:|..||.          .:::|.|||
Worm   190 YEAYKALHFTYLEINPFVLTNGKIHILDLAAKLDETASFLCSDKWSGRNASARIAPTLEFPAPFG 254

  Fly   245 RDAYPEEAYIADLDAKSGASLKLTILNRNGRIWTMVAGGGASVIYSDTICDLGGASELANYGEYS 309
            ||...||.||:|:|||:|||||||||||.||:|||||||||||:::||:|||||:||||||||||
Worm   255 RDLTSEEQYISDMDAKTGASLKLTILNRKGRVWTMVAGGGASVVFTDTVCDLGGSSELANYGEYS 319

  Fly   310 GAPSEQQTYEYAKTILNLMTSSPKHPDGKVLITGGGIANFTNVAATFQGIITALREFQPKLVEHN 374
            |.|||.||||||||||::||.....|||||||.||.||||||||.||.||:.|...|..||.|||
Worm   320 GDPSEAQTYEYAKTILSVMTEGAPRPDGKVLIIGGSIANFTNVAKTFGGIVRAFETFIDKLKEHN 384

  Fly   375 VSIFVRRAGPNYQEGLRKMRDFGSTLGIPLHVFGPETHMTAICGMALGKRPIPQTASVEFSTANF 439
            |||:|||.|||||||||:::|..:.|.||::|||||||||||.|.|||.:|:|...:...:|..|
Worm   385 VSIYVRRGGPNYQEGLRRVKDAATKLEIPIYVFGPETHMTAIVGAALGLKPMPTVPTAPQTTGQF 449

  Fly   440 LL-PGGQQAQADLKAASDASEALGSGSALSPTAAKPIKLPPISADEADSAGISGAQRNGSSLNRK 503
            || |....|..:...||.|..        :.|...|:                 |:|:  .|::.
Worm   450 LLSPERNTAGTERPPASPAPN--------TSTIEHPL-----------------AKRH--PLHQS 487

  Fly   504 FFSNTTKAIVWGMQQRAVQSMLDFDFICRRDEPSVVAMVYPFTGDHKQKYYWGHKEILIPVYKKM 568
            .|.|.||||:||.|.:|:|.||||||:|||..|||||..||||||:|||||:|.||||||.||.|
Worm   488 LFENDTKAIIWGQQHKAIQGMLDFDFVCRRHSPSVVASTYPFTGDNKQKYYFGQKEILIPAYKSM 552

  Fly   569 SDAIHKHKEVDVMVNFASMRSAYESTLEVLEFPQIRTVAIIAEGIPENMTRKLIIEADKKGVAII 633
            :.|...|.:..|||.||||||.:|:.||.|:|.||:.:||||||:|||.||||:..|:.|||.:|
Worm   553 AKAFASHPDATVMVTFASMRSVFETVLEALQFTQIKVIAIIAEGVPENQTRKLLKIAEDKGVTLI 617

  Fly   634 GPATVGGVKPGCFKIGNTGGMLDNILHSKLYRPGSVAYVSRSGGMSNELNNIISKATDGVIEGIA 698
            |||||||:|||||||||||||:||||.|||||||||||||||||||||||||||:.|:||.||||
Worm   618 GPATVGGIKPGCFKIGNTGGMMDNILASKLYRPGSVAYVSRSGGMSNELNNIISQNTNGVYEGIA 682

  Fly   699 IGGDRYPGSTFMDHILRYQADPETKLIVLLGEVGGTEEYDVCAALKDGRITKPLVAWCIGTCASM 763
            ||||||||||:.||::|||.|...|:|||||||||.|||.:...||:.:|||||:||||||||..
Worm   683 IGGDRYPGSTYTDHVMRYQHDDRVKMIVLLGEVGGIEEYRIVELLKEKKITKPLIAWCIGTCADH 747

  Fly   764 FTSEVQFGHAGSCANSDRETATAKNKGLRDAGAYVPDSFDTLGELIHHVYGELVKTGRVVPKEEV 828
            .||||||||||:.||...|||..||..||.|||.||||||.||..|...|.||::...:||:.||
Worm   748 ITSEVQFGHAGASANGQGETAACKNTALRTAGALVPDSFDDLGNKIRQTYEELLRLEIIVPQPEV 812

  Fly   829 PPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPISEVLSKDVGIGGVISLLWFQRC 893
            |||.|||||:|||||||||||||||||||||||:||.|||:||::||..|:|||||:.|||||:.
Worm   813 PPPAVPMDYAWARELGLIRKPASFMTSICDERGEELNYAGVPITKVLESDMGIGGVLGLLWFQKR 877

  Fly   894 LPSYVCKFFEMCLMVTADHGPAVSGAHNTIVCARAGKDLVSSVVSGLLTIGDRFGGALDGSARQF 958
            ||.:..||.|:|||:||||||||||||||||||||||||:||:.||||||||||||||||:||||
Worm   878 LPPHANKFIEICLMLTADHGPAVSGAHNTIVCARAGKDLISSLTSGLLTIGDRFGGALDGAARQF 942

  Fly   959 SEAYDTNLHPMEFVNKMRKEGKLILGIGHRVKSINNPDVRVKIIKEFVL---ENFPACPLLKYAL 1020
            |||:|....|.:||.:|||.|..|:|||||||||||||.||:|:|.|.|   |.....|||.|||
Worm   943 SEAFDQGWSPNQFVGEMRKRGTHIMGIGHRVKSINNPDKRVEILKRFALNKKEFAQETPLLDYAL 1007

  Fly  1021 EVEKITTNKKPNLILNVDGVIATAFVDMLRNSGSFTSEEAQEYINVGAINSLFVLGRSIGFIGHY 1085
            |||||||.|||||||||||.||..|||:|||||.||:.||||.|.:||:|.:|||||||||||||
Worm  1008 EVEKITTAKKPNLILNVDGAIAIIFVDILRNSGMFTTAEAQEVIEIGALNGMFVLGRSIGFIGHY 1072

  Fly  1086 MDQKRLKQGLYRHPWDDISYVIPEQ 1110
            :||.||||||||||||||||::||:
Worm  1073 LDQSRLKQGLYRHPWDDISYIMPER 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPCL	NP_001137674.2	PLN02235	1..421	CDD:177879	243/435 (56%)
		ATP-grasp_4	8..208	CDD:302634	91/205 (44%)
		Citrate_bind	248..423	CDD:292732	126/174 (72%)
		PLN02522	503..1106	CDD:178137	433/605 (72%)
		CoA_binding	504..613	CDD:214881	69/108 (64%)
		Ligase_CoA	672..796	CDD:304578	87/123 (71%)
		CCL_ACL-C	868..1105	CDD:99854	175/239 (73%)
acly-2	NP_506267.1	PLN02235	1..431	CDD:177879	243/435 (56%)
		ATP-grasp_4	8..208	CDD:302634	91/205 (44%)
		Citrate_bind	258..433	CDD:292732	126/174 (72%)
		PLN02522	488..1093	CDD:178137	433/604 (72%)
		CoA_binding	491..596	CDD:280747	67/104 (64%)
		Ligase_CoA	656..781	CDD:278948	88/124 (71%)
		CCL_ACL-C	852..1092	CDD:99854	175/239 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156573
Domainoid	1	1.000	289	1.000	Domainoid score	I840
eggNOG	1	0.900	-	-		E1_COG0045
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H854
Inparanoid	1	1.050	1356	1.000	Inparanoid score	I62
Isobase	1	0.950	-	0	Normalized mean entropy	S1505
OMA	1	1.010	-	-		QHG59168
OrthoDB	1	1.010	-	-		D349367at2759
OrthoFinder	1	1.000	-	-		FOG0003182
OrthoInspector	1	1.000	-	-		otm14216
orthoMCL	1	0.900	-	-		OOG6_101446
Panther	1	1.100	-	-	O	PTHR23118
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R13
SonicParanoid	1	1.000	-	-		X2581
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750