DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pex11 and PEX11B

DIOPT Version :9

Sequence 1:	NP_611071.1	Gene:	Pex11 / 36758	FlyBaseID:	FBgn0034058	Length:	241	Species:	Drosophila melanogaster
Sequence 2:	NP_003837.1	Gene:	PEX11B / 8799	HGNCID:	8853	Length:	259	Species:	Homo sapiens

Alignment Length:	264	Identity:	84/264 - (31%)
Similarity:	138/264 - (52%)	Gaps:	29/264 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDQLVQLNNQAGGRDKIARLIQYASRAMWDSLESANSNPALVDNFKTVEYILSTFRKLLRFGKCV 65
            ||..|:.:.|:..|:::.|..|||...:..:|:...::|.|....:.:|..||..|||||.|...
Human     1 MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQIRQLESHLSLGRKLLRLGNSA 65

  Fly    66 DVFYGALKTIHHPDLNIRVTLTLSKLSQSLFLFADHFLWLARTGLT-AVNAKRWSNIANKYWLFS 129
            |....|.:.:|..|:.:|..:|:|.|:::|:...|:.||..::||. .|:.::|:..:.:|:|||
Human    66 DALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNVLWAGKSGLAPRVDQEKWAQRSFRYYLFS 130

  Fly   130 IIMNLCRDFYEILRVLDLHRS-------GSKSGISRCRIPASINS-------------PEDFKRL 174
            :||||.||.|||..:::...|       ||..|     :|....:             |:...:|
Human   131 LIMNLSRDAYEIRLLMEQESSACSRRLKGSGGG-----VPGGSETGGLGGPGTPGGGLPQLALKL 190

  Fly   175 ALQSYVL---MQGHKDIVVDTVKNACDFFIPLTALGYTSLTPRTIGLLGAISSLAGLWALLEPRA 236
            .||..:|   ::||..:::|.|:||||.||||..||.....|..:||.|.:||:..:..|:.|..
Human   191 RLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGLVSSILSILTLIYPWL 255

  Fly   237 KLTP 240
            :|.|
Human   256 RLKP 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex11	NP_611071.1	PEX11	1..232	CDD:283335	80/254 (31%)
PEX11B	NP_003837.1	PEX11	1..250	CDD:310329	80/253 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..176		4/23 (17%)
		Interaction with PEX19, PEX11G and FIS1 and peroxisome targeting. /evidence=ECO:0000269\|PubMed:10704444, ECO:0000269\|PubMed:20826455	211..259		20/47 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145164
Domainoid	1	1.000	132	1.000	Domainoid score	I5115
eggNOG	1	0.900	-	-		E1_KOG4186
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2852
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4532
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49577
OrthoDB	1	1.010	-	-		D1394894at2759
OrthoFinder	1	1.000	-	-		FOG0003074
OrthoInspector	1	1.000	-	-		otm41088
orthoMCL	1	0.900	-	-		OOG6_103414
Panther	1	1.100	-	-	O	PTHR12652
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1731
SonicParanoid	1	1.000	-	-		X2920
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800