DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8314 and AKR2

DIOPT Version :9

Sequence 1:	NP_611070.1	Gene:	CG8314 / 36757	FlyBaseID:	FBgn0034057	Length:	293	Species:	Drosophila melanogaster
Sequence 2:	NP_014677.1	Gene:	AKR2 / 854199	SGDID:	S000005560	Length:	749	Species:	Saccharomyces cerevisiae

Alignment Length:	233	Identity:	58/233 - (24%)
Similarity:	97/233 - (41%)	Gaps:	43/233 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VIMTWLLILFAEFVVMRLILLPSNYTVFSTINMIIFQALAFLAFASHIRTMLSDPGAVPRGN--- 103
            :|..|...|:...|        |:|    |:..:.|...:||.....:|.:.||||.:...:
Yeast   375 LIYIWTKKLYPYSV--------SDY----TMKNVQFLVTSFLTVVLFLRLVRSDPGCLKTDDSLT 427

  Fly   104 ATKEMIEQ---MGYREGQMFYKCPKCCSIKPERAHHCSVCQRCIRKMDHHCPWVNNCVGENNQKY 165
            :.:|.|:|   :|..:.:.|  |.:....||.|:.:.......:.:.||:|||:.|.||..|.|
Yeast   428 SIQETIKQLIDLGKFDRENF--CVETLERKPLRSKYSFFSGALVARYDHYCPWIYNDVGLKNHK- 489

  Fly   166 FVLFTFYIASISVHT-LFLVL---------------TQFAEC--VKNDWRTCSPYSPPATIFLLL 212
              ||.|:..::..|. ||:.|               .::|.|  :||:.........|:|.||.:
Yeast   490 --LFVFFAVTVQYHMFLFMWLCLAYFKKTNYIYEQVEEYARCALLKNETLCKGSNYDPSTFFLFI 552

  Fly   213 FLTFEGLMFGIFTIIMLATQLTAILNDQTGIEQLKKEE 250
            :::...:..|...|:.....|..|...:..|  |.|||
Yeast   553 WISVNFIWLGAMLIVQFFQILKGITTPELFI--LIKEE 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8314	NP_611070.1	DHHC	122..249	CDD:396215	35/144 (24%)
AKR2	NP_014677.1	ANKYR	1..195	CDD:223738
		ANK repeat	54..81	CDD:293786
		ANK repeat	83..115	CDD:293786
		ANK repeat	117..148	CDD:293786
		ANK repeat	189..220	CDD:293786
		Ank_4	190..243	CDD:372654
		ANK repeat	222..247	CDD:293786
		COG5273	340..711	CDD:227598	58/233 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810