DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8314 and AKR1

DIOPT Version :9

Sequence 1:	NP_611070.1	Gene:	CG8314 / 36757	FlyBaseID:	FBgn0034057	Length:	293	Species:	Drosophila melanogaster
Sequence 2:	NP_010550.1	Gene:	AKR1 / 851857	SGDID:	S000002672	Length:	764	Species:	Saccharomyces cerevisiae

Alignment Length:	238	Identity:	57/238 - (23%)
Similarity:	88/238 - (36%)	Gaps:	37/238 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ICGIVCVIMTWLLILFAEFVVMRLILLPSNYTVFSTINMIIFQALAFLAFASHIRTMLSDPGAVP 100
            :.|:....:.|:.|::. |.||........||   .|.|::.....|..|.   :.::.|||.:|
Yeast   388 LSGVFFGTLLWVTIVWF-FKVMPRTFSDEQYT---NILMLVILVSVFYLFG---QLVIMDPGCLP 445

  Fly   101 RGNATKEMIEQ-------MGYREGQMFYKCPKCCSIKPERAHHCSVCQRCIRKMDHHCPWVNNCV 158
            . ....|.:.|       :|..:.:.|  |.:....||.|:....:....:.:.||:|||:.|.|
Yeast   446 E-ETDHENVRQTISNLLEIGKFDTKNF--CIETWIRKPLRSKFSPLNNAVVARFDHYCPWIFNDV 507

  Fly   159 GENNQKYFVLFTFYIASISVHTLFLVLTQFAECVKNDWRT---------------CSPYSPPATI 208
            |..|.|.|:.|...:.|.....|.|.|..|.|.......|               ||.......:
Yeast   508 GLKNHKAFIFFITLMESGIFTFLALCLEYFDELEDAHEDTSQKNGKCFILGASDLCSGLIYDRFV 572

  Fly   209 FLLLFLTFEGLMFGIFTIIMLATQLTAILNDQTGIE--QLKKE 249
            ||:|..   .|:..|:...::..|...|....|..|  .|.||
Yeast   573 FLILLW---ALLQSIWVASLIFVQAFQICKGMTNTEFNVLMKE 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8314	NP_611070.1	DHHC	122..249	CDD:396215	35/143 (24%)
AKR1	NP_010550.1	ANK repeat	75..101	CDD:293786
		ANKYR	78..270	CDD:223738
		ANK repeat	103..140	CDD:293786
		ANK repeat	142..173	CDD:293786
		ANK repeat	213..244	CDD:293786
		ANK repeat	246..271	CDD:293786
		COG5273	363..725	CDD:227598	57/238 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810