DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8314 and Zdhhc2

DIOPT Version :9

Sequence 1:	NP_611070.1	Gene:	CG8314 / 36757	FlyBaseID:	FBgn0034057	Length:	293	Species:	Drosophila melanogaster
Sequence 2:	NP_848482.1	Gene:	Zdhhc2 / 70546	MGIID:	1923452	Length:	366	Species:	Mus musculus

Alignment Length:	315	Identity:	81/315 - (25%)
Similarity:	131/315 - (41%)	Gaps:	60/315 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSPGGSGGFGGVDQHNRCCGNKAWCVKDICGIVCVIMTWLLILFAEFVVMRLILLPSNYTVFSTI 72
            ::|.||||.     ..||.....|        :.|:...||:.::.:.....:.:.|...:...:
Mouse     1 MAPSGSGGV-----RRRCRRVLYW--------IPVVFISLLLGWSYYAYAIQLCIVSMENIGEQV 52

  Fly    73 NMIIFQALAFLAFA-SHIRTMLSDP-----------------GAVPRGNATKEMIEQMG------ 113
            ..::...|.|..|. |:.:|:.:.|                 ...|||.|.:|::.:..
Mouse    53 VCLMAYHLLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKELLEREPRGEAHQEVLRRAAKDLPIY 117

  Fly   114 --YREGQMFYKCPKCCSIKPERAHHCSVCQRCIRKMDHHCPWVNNCVGENNQKYFVLFTFYIASI 176
              ...|.:.| |.:|..|||:|.||||||.:||.||||||||||||||.:|.|:|:||..|..
Mouse   118 TRTMSGAIRY-CDRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSL-- 179

  Fly   177 SVHTLFLVLTQFAECVKNDWRTCSPYSPPATIFLLLFLTFEGLMFGIFTIIMLATQLTAILNDQT 241
             ::.||:..|.....:: .|....|.:...  |.::||.|...||.:....:.......:..:::
Mouse   180 -LYCLFIAATDLQYFIR-FWTNGLPDTQAK--FHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNKS 240

  Fly   242 GIEQLKKEEARWAKKSR------LKSIQSVFGRFSLAWFSP-FTE-------PSC 282
            .:|..:....|......      .|:::.|||.....|..| |:.       |:|
Mouse   241 TLEAFRNPVFRHGTDKNGFSLGFSKNMRQVFGDEKKYWLLPVFSSQGDGCSFPTC 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8314	NP_611070.1	DHHC	122..249	CDD:396215	46/126 (37%)
Zdhhc2	NP_848482.1	DHHC	126..247	CDD:366691	47/127 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	296..366		81/315 (26%)
		Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000269\|PubMed:21471008	298..366
		Non-canonical dileucine endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	334..335
		NPxY-like endocytic signal. /evidence=ECO:0000269\|PubMed:28768144	357..360
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820