DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8314 and ZDHHC6

DIOPT Version :9

Sequence 1:	NP_611070.1	Gene:	CG8314 / 36757	FlyBaseID:	FBgn0034057	Length:	293	Species:	Drosophila melanogaster
Sequence 2:	NP_001338011.1	Gene:	ZDHHC6 / 64429	HGNCID:	19160	Length:	413	Species:	Homo sapiens

Alignment Length:	271	Identity:	73/271 - (26%)
Similarity:	109/271 - (40%)	Gaps:	49/271 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FGGVDQHNRCCGNKAWCVKDICGIVCVIMTWLLILFAEFVVMRLILLPSNYTVFSTINMIIFQAL 80
            |..:.:..|.|   .|......|::.:..|..:|   :.|:....|    :|...::|.|:....
Human    10 FENLQELKRLC---HWGPIIALGVIAICSTMAMI---DSVLWYWPL----HTTGGSVNFIMLINW 64

  Fly    81 AFLAFASHIRTMLSDPGAVPRGNATKEMIEQMGYREGQMFYKCPKCCSIKPERAHHCSVCQRCIR 145
            ..:...::...|...||.||.|  .|..|.|    :......|..|.:.|..|:|||..|.||:.
Human    65 TVMILYNYFNAMFVGPGFVPLG--WKPEISQ----DTMYLQYCKVCQAYKAPRSHHCRKCNRCVM 123

  Fly   146 KMDHHCPWVNNCVGENNQKYFVLFTFYIASISVHTLFL-VLTQFAEC---VKNDWRTCS------ 200
            ||||||||:|||.|..|...|.||........:|..|: |:|.:.:.   :...|.|..
Human   124 KMDHHCPWINNCCGYQNHASFTLFLLLAPLGCIHAAFIFVMTMYTQLYHRLSFGWNTVKIDMSAA 188

  Fly   201 -----PYSP------PATIFLLLFLTFEGLMFG--IFTIIMLATQLTAILNDQTGIEQLKKEEAR 252
                 |..|      ..|:|.|      ||..|  |...::...|:..||.::|.||...:|:|
Human   189 RRDPLPIVPFGLAAFATTLFAL------GLALGTTIAVGMLFFIQMKIILRNKTSIESWIEEKA- 246

  Fly   253 WAKKSRLKSIQ 263
               |.|::..|
Human   247 ---KDRIQYYQ 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8314	NP_611070.1	DHHC	122..249	CDD:396215	47/149 (32%)
ZDHHC6	NP_001338011.1	DHHC	95..241	CDD:396215	47/151 (31%)
		SH3	317..394	CDD:418401
		Di-lysine motif. /evidence=ECO:0000269\|PubMed:21926431	410..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1491968at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820