DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strn-Mlck and ZC3H11A

DIOPT Version :9

Sequence 1:	NP_001261019.1	Gene:	Strn-Mlck / 36753	FlyBaseID:	FBgn0265045	Length:	8255	Species:	Drosophila melanogaster
Sequence 2:	NP_001306167.1	Gene:	ZC3H11A / 9877	HGNCID:	29093	Length:	810	Species:	Homo sapiens

Alignment Length:	807	Identity:	168/807 - (20%)
Similarity:	289/807 - (35%)	Gaps:	214/807 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  4614 ESQKEEVKDSEAKPKKAKVLEKKSIEEEKL--EDKKEKQTESAIDEKSQKAEVSE---------I 4667
            ||.:||||.|:.           |:::.||  :.....|..|.:     |.|.||         :
Human   107 ESPEEEVKASQL-----------SVQQNKLSVQSNPSPQLRSVM-----KVESSENVPSPTHPPV 155

  Fly  4668 VSEKITDEKAQESQMEEVKDSEAKPKKAKVLEKKSIEEAKLEDKKETQTDSAIDEKSQKAEVSEI 4732
            |.....|::..:.|..|..|....|              .|:...|......:....:.|
Human   156 VINAADDDEDDDDQFSEEGDETKTP--------------TLQPTPEVHNGLRVTSVRKPA----- 201

  Fly  4733 VSEKITDEKAQESQKEEVKDSEAKPKKAKVLEKKSIEEEKLEDKKEKQTESAIDEKS-------- 4789
                           ..:|..|......|.||:  |:.:|:::|.:||.|.:....|
Human   202 ---------------VNIKQGECLNFGIKTLEE--IKSKKMKEKSKKQGEGSSGVSSLLLHPEPV 249

  Fly  4790 ---QKAEVSEIVSEKITDEKAQE------------SQKKEVKGSEAKPKKAKVLEKKSIEEEKLE 4839
               :|..|..:|.......|..|            .::|...|.::.|...:.|.::.
Human   250 PGPEKENVRTVVRTVTLSTKQGEEPLVRLSLTERLGKRKFSAGGDSDPPLKRSLAQRL------- 307

  Fly  4840 DKKEKQTESAIDEKSQKAEVSEIVSEKI-----TDEKAQESQKKEVKDSEAKPKKAKVLEKKSIE 4899
            .||.:..|:.||:..:||:||:.:.|::     .|.:....:..:|.:...|..:..:||:.|.:
Human   308 GKKVEAPETNIDKTPKKAQVSKSLKERLGMSADPDNEDATDKVNKVGEIHVKTLEEILLERASQK 372

  Fly  4900 EEKLENKKEKQTESAIDEKSQKAEVSEIVSEKITDEKAQESQKKEVKDSEAKPKKAKVLEKKSIE 4964
            ..:|:.|.:.:..|..|:.:..|..|..:..|...|...|.:.::.:....|.||.....|..|:
Human   373 RGELQTKLKTEGPSKTDDSTSGARSSSTIRIKTFSEVLAEKKHRQQEAERQKSKKDTTCIKLKID 437

  Fly  4965 EEKLEDKK----------EKQTESAIDEKFQKAEVSETVSEKITDEKA------EESRKEEVKDS 5013
            .   |.||          ..|:|....:.....||.....|:|..|||      .||........
Human   438 S---EIKKTVVLPPIVASRGQSEEPAGKTKSMQEVHIKTLEEIKLEKALRVQQSSESSTSSPSQH 499

  Fly  5014 EAKP---KKAKVLEKKSIEEEK-LEDKKEKQTESAIDEKSQKAEVSETVSEKITDEKAQESQKKE 5074
            ||.|   :..::.::..::||| |::..|..::|:|..::::|. .||....||        |.:
Human   500 EATPGARRLLRITKRTGMKEEKNLQEGNEVDSQSSIRTEAKEAS-GETTGVDIT--------KIQ 555

  Fly  5075 VKDSEAKPKKAKILEKKSIEIEKLDEKKEKQTETKVATDTKSQTVEVSE---------IVLEKIS 5130
            ||..|.  .:.|.::|:        :::||...|.:..|..|...:|:|         |......
Human   556 VKRCET--MREKHMQKQ--------QEREKSVLTPLRGDVASCNTQVAEKPVLTAVPGITRHLTK 610

  Fly  5131 EEKAEESQKVELK-----DSEAKSK-KAKVLEKKSTLKEKLDENDKKQKEDGATNKSQKAEAADV 5189
            ....:.|||||::     ||....| .|:.|||:...|.|::......|...:...:.|.:|.
Human   611 RLPTKSSQKVEVETSGIGDSLLNVKCAAQTLEKRGKAKPKVNVKPSVVKVVSSPKLAPKRKAV-- 673

  Fly  5190 VPEKISEEKVAEIKTPEPMDSKAKSKPDGLPADEKSHGAKVSESVPVKNEAEKTDQLSAKKPTVL 5254
                  |...|.|...:|:.|                 :.|.:..|.|..|.....|.::
Human   674 ------EMHAAVIAAVKPLSS-----------------SSVLQEPPAKKAAVAVVPLVSE----- 710

  Fly  5255 DEDLVVPKRKPYLAEQTADSISL-QTYKSMDS-------------EYKDRKESRSAKRKPTVDIQ 5305
            |:.:.||:     ||...||:.| .|..|.||             ..|.|:.|.::..||.:.::
Human   711 DKSVTVPE-----AENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASTGKPPLSVE 770

  Fly  5306 LTNRNTASGSDL-KLTCGLSGHEMNVQ 5331
                     .|. ||...:||.::..:
Human   771 ---------DDFEKLIWEISGGKLEAE 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strn-Mlck	NP_001261019.1	IG_like	51..127	CDD:214653
		Ig	<69..>112	CDD:299845
		I-set	137..226	CDD:254352
		I-set	235..314	CDD:254352
		Ig_2	244..314	CDD:290606
		I-set	438..513	CDD:254352
		Ig	454..510	CDD:143165
		I-set	537..626	CDD:254352
		Ig	555..618	CDD:299845
		I-set	636..713	CDD:254352
		Ig	652..712	CDD:143165
		SMC_N	<2190..2854	CDD:280601
		I-set	5300..5388	CDD:254352	6/33 (18%)
		IGc2	5313..5378	CDD:197706	5/20 (25%)
		IG	5412..5482	CDD:214652
		IGc2	5413..5481	CDD:197706
		I-set	5542..5627	CDD:254352
		Ig	5556..5621	CDD:143165
		Ig	5654..5721	CDD:143165
		I-set	5784..5874	CDD:254352
		IGc2	5797..5864	CDD:197706
		I-set	5887..5970	CDD:254352
		Ig	5902..5966	CDD:143165
		I-set	5997..6086	CDD:254352
		Ig	6026..6083	CDD:143165
		I-set	6097..6187	CDD:254352
		Ig	6114..6187	CDD:299845
		FN3	6216..6310	CDD:238020
		I-set	6321..6412	CDD:254352
		Ig	6328..6412	CDD:299845
		I-set	6442..6531	CDD:254352
		Ig	6459..6528	CDD:143165
		I-set	6541..6632	CDD:254352
		IGc2	6555..6622	CDD:197706
		I-set	6662..6754	CDD:254352
		Ig	6679..6751	CDD:143165
		I-set	6779..6868	CDD:254352
		IGc2	6793..6858	CDD:197706
		Ig	6938..7022	CDD:299845
		I-set	6939..7028	CDD:254352
		IG	7075..7140	CDD:214652
		Ig	7075..7140	CDD:143165
		IG	7167..7239	CDD:214652
		Ig	7173..7239	CDD:143165
		Ig	7392..7475	CDD:299845
		IG	7406..7475	CDD:214652
		FN3	7489..7588	CDD:238020
		S_TKc	7620..7876	CDD:214567
		STKc_MLCK	7626..7876	CDD:271005
ZC3H11A	NP_001306167.1	zf-CCCH_3	1..110	CDD:373997	2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..194		12/73 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..258		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..351		15/72 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	367..432		14/64 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..549		16/67 (24%)
		Caprin-1_C	687..>773	CDD:372014	23/121 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..768		16/57 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.918296	Normalized mean entropy	S8347
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950