DRSC/TRiP Functional Genomics Resources

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Protein Alignment Strn-Mlck and MYLK3

DIOPT Version :9

Sequence 1:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster
Sequence 2:NP_872299.2 Gene:MYLK3 / 91807 HGNCID:29826 Length:819 Species:Homo sapiens


Alignment Length:719 Identity:238/719 - (33%)
Similarity:349/719 - (48%) Gaps:132/719 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  7260 SSSGELCVLERDLR--GQDEECVQLLK---TPLPVVCASG---DEALFYARVFPCDAEADWYLNG 7316
            |:||    ::.|.|  |::.:...:|:   ..||.:.|||   |.|  .|.|.|          |
Human   176 STSG----VQSDAREPGEESQKADVLEGTAERLPPIRASGLGADPA--QAVVSP----------G 224

  Fly  7317 QLLAQADDSLNMTLESYPENGIRLLRMRDVTASRSGEICLQVKHPQAEFRRIPTTRTYTSLLVLP 7381
            |     .|.:....:::|                 |.:.|..| .:|:....|:....|.|.:.|
Human   225 Q-----GDGVPGPAQAFP-----------------GHLPLPTK-VEAKAPETPSENLRTGLELAP 266

  Fly  7382 AI-RGNSSSSSL-----AARSCILTRPEDCTALIGGHVRLSVRYEPFPGTKV-------IWYKAC 7433
            |. |.|..|.||     |.:....:|| |...|..|     .|..|.||.:.       ...:|.
Human   267 APGRVNVVSPSLEVAPGAGQGASSSRP-DPEPLEEG-----TRLTPGPGPQCPGPPGLPAQARAT 325

  Fly  7434 HPIVESSNVTIRTTSQQSTLYITDISADDSGKYTVEVMNDYG----VEA-AAASVAVEGPP---- 7489
            |...|        |..:.:::|.::  |..|:..:......|    .|| |||....:|||    
Human   326 HSGGE--------TPPRISIHIQEM--DTPGEMLMTGRGSLGPTLTTEAPAAAQPGKQGPPGTGR 380

  Fly  7490 --EPPSGQP-------SVSLGPDRVAVAWCGPPYDGGCMITGFIIEMQTIGDE---------NCD 7536
              :.|..:|       :..|.|.:.:.:      .||....    |.|..|.|         :.|
Human   381 CLQAPGTEPGEQTPEGARELSPLQESSS------PGGVKAE----EEQRAGAEPGTRPSLARSDD 435

  Fly  7537 EDSWQQVTRVVDSLAYTVKNLQPERQYRFR--VRAENIHGRSAPGQASELVQITNTPQRSTSSDA 7599
            .|.......:....:....|.:||:....|  ||||.:. |..||..:..|.:.::|.....   
Human   436 NDHEVGALGLQQGKSPGAGNPEPEQDCAARAPVRAEAVR-RMPPGAEAGSVVLDDSPAPPAP--- 496

  Fly  7600 SDRFGQATVSVQSGGDFKSRFEII--EELGKGRFGIVYKVQER--GQPEQLLAAKVIKCIKSQDR 7660
               |....|||:. ....:.:|:.  |.||.||||.|::..|:  |.|   ||||:||...::||
Human   497 ---FEHRVVSVKE-TSISAGYEVCQHEVLGGGRFGQVHRCTEKSTGLP---LAAKIIKVKSAKDR 554

  Fly  7661 QKVLEEISIMRALQHPKLLQLAASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQ 7725
            :.|..||:||..|.|..|:||..:|||.....:||||:.|||||:|:..:.:.|||:|.:||.||
Human   555 EDVKNEINIMNQLSHVNLIQLYDAFESKHSCTLVMEYVDGGELFDRITDEKYHLTELDVVLFTRQ 619

  Fly  7726 VCDGVAYMHGQSVVHLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEII 7790
            :|:||.|:|...::|||||||||:|..:|.|||||||||||:|...:..::|.||||||:.||::
Human   620 ICEGVHYLHQHYILHLDLKPENILCVNQTGHQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVV 684

  Fly  7791 SYEPIGFQSDMWSVGVICYVLLSGLSPFMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQ 7855
            :||.:.|.:||||||||.|:||||||||:|:||.||.:.|....:|:|.:.|:.:|:|||||:|:
Human   685 NYEFVSFPTDMWSVGVITYMLLSGLSPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSR 749

  Fly  7856 LLVHRKEDRLTAQQCLASKWLSQRP-DDSLSNNKICTD-KLKKFIIRRKWQKTGNAIRALGRMAN 7918
            |||..|..|::|.|||..:||:..| ..|.|..::.:. .|:|:|.:|||:|....:.|..|:..
Human   750 LLVKEKSCRMSATQCLKHEWLNNLPAKASRSKTRLKSQLLLQKYIAQRKWKKHFYVVTAANRLRK 814

  Fly  7919 LSVS 7922
            ...|
Human   815 FPTS 818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Strn-MlckNP_001261019.1 IG_like 51..127 CDD:214653
Ig <69..>112 CDD:299845
I-set 137..226 CDD:254352
I-set 235..314 CDD:254352
Ig_2 244..314 CDD:290606
I-set 438..513 CDD:254352
Ig 454..510 CDD:143165
I-set 537..626 CDD:254352
Ig 555..618 CDD:299845
I-set 636..713 CDD:254352
Ig 652..712 CDD:143165
SMC_N <2190..2854 CDD:280601
I-set 5300..5388 CDD:254352
IGc2 5313..5378 CDD:197706
IG 5412..5482 CDD:214652
IGc2 5413..5481 CDD:197706
I-set 5542..5627 CDD:254352
Ig 5556..5621 CDD:143165
Ig 5654..5721 CDD:143165
I-set 5784..5874 CDD:254352
IGc2 5797..5864 CDD:197706
I-set 5887..5970 CDD:254352
Ig 5902..5966 CDD:143165
I-set 5997..6086 CDD:254352
Ig 6026..6083 CDD:143165
I-set 6097..6187 CDD:254352
Ig 6114..6187 CDD:299845
FN3 6216..6310 CDD:238020
I-set 6321..6412 CDD:254352
Ig 6328..6412 CDD:299845
I-set 6442..6531 CDD:254352
Ig 6459..6528 CDD:143165
I-set 6541..6632 CDD:254352
IGc2 6555..6622 CDD:197706
I-set 6662..6754 CDD:254352
Ig 6679..6751 CDD:143165
I-set 6779..6868 CDD:254352
IGc2 6793..6858 CDD:197706
Ig 6938..7022 CDD:299845
I-set 6939..7028 CDD:254352
IG 7075..7140 CDD:214652
Ig 7075..7140 CDD:143165
IG 7167..7239 CDD:214652
Ig 7173..7239 CDD:143165
Ig 7392..7475 CDD:299845 18/94 (19%)
IG 7406..7475 CDD:214652 13/75 (17%)
FN3 7489..7588 CDD:238020 25/122 (20%)
S_TKc 7620..7876 CDD:214567 133/259 (51%)
STKc_MLCK 7626..7876 CDD:271005 131/251 (52%)
MYLK3NP_872299.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 146..334 49/210 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 347..462 24/124 (19%)
STKc_MLCK3 510..770 CDD:271094 133/262 (51%)
S_TKc 513..770 CDD:214567 133/259 (51%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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