DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strn-Mlck and YML002W

DIOPT Version :9

Sequence 1:	NP_001261019.1	Gene:	Strn-Mlck / 36753	FlyBaseID:	FBgn0265045	Length:	8255	Species:	Drosophila melanogaster
Sequence 2:	NP_013712.1	Gene:	YML002W / 855011	SGDID:	S000004461	Length:	737	Species:	Saccharomyces cerevisiae

Alignment Length:	958	Identity:	183/958 - (19%)
Similarity:	320/958 - (33%)	Gaps:	336/958 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1775 KMQELQSSLAVVQETNLVEAAHSMSEASQQGTFAEALCSLERCVLQVEECMAHSGVESLTDLELS 1839
            :.:.|:|.|..:|..:      :.|.:::.|....|:.:||..|...|:...::|       .::
Yeast    34 EQKHLKSHLYYLQNFS------NNSSSTKFGILGYAVSTLEAVVCYFEDFNKNTG-------NVA 85

  Fly  1840 KLKTLATPLHDVRQYCEQ----IDVQLLEN----VIDISTHGDISELKSSGHQQTVSDHIQEVAV 1896
            |..||          ||:    :|....||    |.|::|:.||...::...|..:|
Yeast    86 KANTL----------CEKTKNLLDKLSCENPTNEVEDLATYKDILTYRNEQGQSILS-------- 132

  Fly  1897 VEEEPQVEVFDIQQGVASGIKQLEACLEVTQTDANKELQQVGKIMEQLKSDLENIQIALVTDTVQ 1961
                                    .|:      .|.:...:..|:.:.::|..      |.|.::
Yeast   133 ------------------------ICI------TNHKNYILLDILSEYENDFP------VEDLLE 161

  Fly  1962 QETVLAQAQIARTMFRLKECLVHTYESGLVDSLENVESAFEDILLSLPILESQLAEEMFAKIEKA 2026
            .||:....           .|:.:.::|      |:|:|  .:|:.: :|.:...||:.:.|.|.
Yeast   162 DETIDGST-----------LLIESIKAG------NLEAA--KVLIKI-MLFNCTEEELVSYINKT 206

  Fly  2027 --FANFVAYCERPEAVDYQKLKTLKQPIENLVGSIGAVAAQPTVDVDKSSSVVVQLQTSLMAAFR 2089
              :|..||:....|.              :::.|||..     :|..:.:|   ..||.|.:.||
Yeast   207 DKYARTVAHYLTHEM--------------DILKSIGNY-----IDWKRKNS---SGQTPLFSIFR 249

  Fly  2090 CIN--DVSEQISN--EVLGGLLKTQSSLVAVFDFIEGNDN-----------TIRVIELLQEMD-- 2137
            ..:  :..|.:..  ::.....:..:||   ||:::..||           .|.::..|.::|
Yeast   250 SYDQPNYEEMVKTAFDIANTWYRKHNSL---FDYLDHTDNKGNSLLHVLKTNIPILLQLTKLDIN 311

  Fly  2138 ----------SITAELKALSEIHVEPTVPIDIGIIIENVSSGKAFLTEIEEGLRVNNPTCILLLD 2192
                      .:..:.|.||.|   ..:..|..:|:|.|.:...|             ||.
Yeast   312 EENYKGLTPLMVYVKYKRLSNI---DAITKDRRLILEKVQNSTFF-------------TCF---- 356

  Fly  2193 ENTDDIAQLEATLVQIEKEILSQPQLSQITTKQFALIDALQLQISNLQEKLNKLNVFLSELQSQS 2257
                |.|:        :..:||:.....:....|.||....|:..||....|        :.|.|
Yeast   357 ----DYAK--------DHSVLSKIGERGVKDSLFGLIYFHSLRYHNLNATTN--------ITSVS 401

  Fly  2258 DVSSPESALDTDIDLKEGSGSQEDI---EPEAKRPKMLESEQQLDSYKQTETQEEVPKETDDETK 2319
            :...|.:.  |.|::|...|....|   .|....|        |::|
Yeast   402 NAEKPFAT--TVINMKTIQGLLRSILKDNPFTFLP--------LNTY------------------ 438

  Fly  2320 KDIEVESKLENQNELVAKKDEQKADKVSEQEKLQESKQQTEVDDTQKSTEVVSQKASPENI---- 2380
              |:..|.| |:::|..   ..|.|..|...:|           |.....::..|..|||:
Yeast   439 --IDEISHL-NRSDLTI---IGKTDVTSLLHQL-----------TNCFNVLLFLKKIPENLFTDE 486

  Fly  2381 ------LEALSEKLSQSPN-----NATQNDEIKTIMTECQDILD-NIDNIEKVSKSIFKLREHIV 2433
                  :...:.|.:|.|:     ...:.:||..|    |..|. |.|.|.....|:..||:.::
Yeast   487 ASILYWMRINTSKRNQKPSGKENPKTMEPEEINMI----QSFLRFNFDEISSFKASLNILRKVLI 547

  Fly  2434 HTFDGKPPEEQTEK---ELVEKLIESLFESCPEATEHVIQTYIKEIKTNIILTKAAIQLIDDSNL 2495
            .........|...|   |:..|||.|      ||:     :..|.|.||             .|:
Yeast   548 FINLKSDDFEDAYKGLNEMGRKLINS------EAS-----SAFKGIITN-------------HNM 588

  Fly  2496 FTKPSL--LVPKLVNLE----KLSELTQTVKLIDKSSK------EMIGLQQNLMDIFIILDDLLD 2548
            |::.||  |:..:..||    :||...|.: |.:|...      |.:.|.::....|
Yeast   589 FSELSLAALLENVRFLEQCTIQLSSFVQII-LFEKIPNWWKHYGEFLALHKSYRKAF-------- 644

  Fly  2549 ERTEKINPKIENIKKILLSEYDYIEKKEGQLNTAVVNGKIKLITEKILDICEEFKQIIESQNQNK 2613
              ...:.||..:..........:||.|..|             :|:.|.:            |.|
Yeast   645 --PNMVKPKSASDTSSRAPLGGFIETKREQ-------------SEQRLAV------------QIK 682

  Fly  2614 DAAGDIKKSETEDVVDHSIEKKIEEPKRSEKKDLDKEFLEEKELKASA 2661
            .::..:|:..:|..|.|  |:..||  .|...:..|..|:::.|.|.|
Yeast   683 ASSKMLKELGSEIFVAH--ERLAEE--LSNYMEFRKACLDQRSLVAFA 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strn-Mlck	NP_001261019.1	IG_like	51..127	CDD:214653
		Ig	<69..>112	CDD:299845
		I-set	137..226	CDD:254352
		I-set	235..314	CDD:254352
		Ig_2	244..314	CDD:290606
		I-set	438..513	CDD:254352
		Ig	454..510	CDD:143165
		I-set	537..626	CDD:254352
		Ig	555..618	CDD:299845
		I-set	636..713	CDD:254352
		Ig	652..712	CDD:143165
		SMC_N	<2190..2854	CDD:280601	102/506 (20%)
		I-set	5300..5388	CDD:254352
		IGc2	5313..5378	CDD:197706
		IG	5412..5482	CDD:214652
		IGc2	5413..5481	CDD:197706
		I-set	5542..5627	CDD:254352
		Ig	5556..5621	CDD:143165
		Ig	5654..5721	CDD:143165
		I-set	5784..5874	CDD:254352
		IGc2	5797..5864	CDD:197706
		I-set	5887..5970	CDD:254352
		Ig	5902..5966	CDD:143165
		I-set	5997..6086	CDD:254352
		Ig	6026..6083	CDD:143165
		I-set	6097..6187	CDD:254352
		Ig	6114..6187	CDD:299845
		FN3	6216..6310	CDD:238020
		I-set	6321..6412	CDD:254352
		Ig	6328..6412	CDD:299845
		I-set	6442..6531	CDD:254352
		Ig	6459..6528	CDD:143165
		I-set	6541..6632	CDD:254352
		IGc2	6555..6622	CDD:197706
		I-set	6662..6754	CDD:254352
		Ig	6679..6751	CDD:143165
		I-set	6779..6868	CDD:254352
		IGc2	6793..6858	CDD:197706
		Ig	6938..7022	CDD:299845
		I-set	6939..7028	CDD:254352
		IG	7075..7140	CDD:214652
		Ig	7075..7140	CDD:143165
		IG	7167..7239	CDD:214652
		Ig	7173..7239	CDD:143165
		Ig	7392..7475	CDD:299845
		IG	7406..7475	CDD:214652
		FN3	7489..7588	CDD:238020
		S_TKc	7620..7876	CDD:214567
		STKc_MLCK	7626..7876	CDD:271005
YML002W	NP_013712.1	VPS9	<8..79	CDD:388595	11/50 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344834
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930