DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strn-Mlck and nexn

DIOPT Version :9

Sequence 1:	NP_001261019.1	Gene:	Strn-Mlck / 36753	FlyBaseID:	FBgn0265045	Length:	8255	Species:	Drosophila melanogaster
Sequence 2:	NP_001077324.2	Gene:	nexn / 573301	ZFINID:	ZDB-GENE-041114-92	Length:	861	Species:	Danio rerio

Alignment Length:	1117	Identity:	240/1117 - (21%)
Similarity:	452/1117 - (40%)	Gaps:	320/1117 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  4323 ETQTDSAIDEKSQKAEVSEIVSEKITDEKAQESQKEEVKDSEAKPKKAKVL----EKKSIEEEKL 4383
            :..||:.::......:::::.||...:|   |:.|||..|....|::.::.    |.|..|..:.
Zfish     9 DVSTDTHMNNTESMNDIADVDSENTVNE---ENHKEETHDMCCAPEEVEMNSAADEPKETELPEK 70

  Fly  4384 ENKKEKQTESAIDEKSQKAEVSEIVSEKITDEKAQESQKKEVKG-SEAKPKKAKVLE-KKSIEEE 4446
            |..|::...:...|:.||.: .|..|:...:|||.||...::.. |:...|:.|:|: .|.::..
Zfish    71 EKPKQETGRARKRERVQKTK-EEDTSQLENEEKADESHDIDITNMSDVALKQEKLLKTSKPVQRS 134

  Fly  4447 KL-----EDKKEK--QTESAIDEKSQKAEVSEIVSEKITDEKAQESQKEE----VKDSEAKPKKA 4500
            .:     ||.|.|  ..:.|.:|::||              ::||.||:.    ||:.|...:|.
Zfish   135 YIPKLGKEDVKNKFEAMQKAREERNQK--------------RSQEEQKKRREQYVKEREYGRRKQ 185

  Fly  4501 KVLE--KKSIEEAKLEDKKETQTDSAIDEKSQKAEVSEIVSEKITDEKAQESQKEEVKDSEAKPK 4563
            .:.|  ..|.||   |:.|.|:.     |||...:::..|..|..:.:.|..::|..:..|.:.|
Zfish   186 MIKELLASSDEE---EEVKPTKI-----EKSYVPKITGSVKGKFAEMEKQRQEEERKRTDEERKK 242

  Fly  4564 KA--KVLEKKSIEEAKLEDKKETQTDSA-----IDEKSQKAEVSEIVSEKITDEKAQESQKEEVK 4621
            :|  :.:||..|:: :|..|.|.:.|.:     :..|||| :...|   ||..|..::|::||:
Zfish   243 RAAQEAIEKAKIQK-ELAKKAEEEGDDSLLVRVVPAKSQK-QPGRI---KINFEDMEKSREEEL- 301

  Fly  4622 DSEAKPKKAKVLEKKSIEEEKLEDKKEKQTESAIDEKSQKAEVSEIVSEKITDEKAQESQMEEVK 4686
                         ||..||||::         ..||..:...           |..:.|.:|::.
Zfish   302 -------------KKRTEEEKMK---------RYDENRRSVR-----------ESKRRSVVEQLD 333

  Fly  4687 DSEAKPKKAKVLEKKSIEEAKLEDKKETQTDSAIDEKSQKAEVSEIVSEKIT-DEKAQESQKEEV 4750
            |.|.:||     ||:.:...||                           ::| :|:.:|.|:::.
Zfish   334 DGEPQPK-----EKEQVTPGKL---------------------------RLTFEEQEKERQEQQR 366

  Fly  4751 KDSEAKPKKAKVLEKKSIEEEKLEDKKEKQTESAIDEKSQKAEVSEIVSEKITDEKAQESQ-KKE 4814
            |.:|.:.::....|:|:.||.||...:|                         ||..|::. :||
Zfish   367 KQAEEEARRRLEEERKAFEEAKLGMGQE-------------------------DEDTQDTHGEKE 406

  Fly  4815 VKGSEAKPKKAKVLEKKSIEEEKLEDKKEKQTESAIDEKSQKAEVSEIVSEKITDEKA-QESQKK 4878
                |.:|.|.: |..:.:|.::|||:.::.      |:.:|..:.|       :.|| .|::|.
Zfish   407 ----EFRPGKLR-LSFEELERQRLEDEHKRV------EEERKRRIEE-------ERKAFAEARKS 453

  Fly  4879 EVKDSE------------AKPKKAKV----LEKKSIEEEKLENKKEKQTESAIDEKSQK-AEVSE 4926
            .|.:|:            |||.|..:    ||::..|||  :.:||::.:..::|:.:. ||..:
Zfish   454 MVINSDDDILLAMINSDGAKPGKLAISFEDLERQRQEEE--QKRKEEEAKRRLEEEKRLFAEARK 516

  Fly  4927 IVSEKITDEKAQESQKKEVKDSEAKPKKAKVLEKKSIEEEKLEDKKEKQTESAIDEKFQKAEVSE 4991
            .:|..:..:.......|||.|.:      :.|.:...:|.....|.|...|..:..|
Zfish   517 SMSPGVDQDNMTGCGDKEVLDDD------ETLVRTESQEGLHPGKLEINFEEMLKMK-------- 567

  Fly  4992 TVSEKITDEKAEESRKEEVKDSEAKPKKAKVLEKKSIEEEKLEDKKEKQTESAIDEKSQKAEVSE 5056
                    |:||..||:|.:           .:|..:|:::.|..:::..|..|:|.|   ||..
Zfish   568 --------EEAERKRKQEAR-----------RQKMEMEKKEFEQLRQEMGEEEINESS---EVVS 610

  Fly  5057 TVSEKITDEKAQESQKKEVKDSEAKPKKAKILEKKSIEIEKLDEKKEKQTETKVATDTKSQTVEV 5121
            ...|::|  |.:.:...:.|..::|.:|.|.|.::.|: :|::|::.::.|
Zfish   611 AEYEELT--KLKRTGSIQAKSLKSKFEKIKQLTEEEIQ-KKIEEERARRKE-------------- 658

  Fly  5122 SEIVLEKISEEKAEESQKVELKDSEAKSKKAKVLEKKSTLKEKLDENDKKQKEDGATNKSQKAEA 5186
               :.|:|.|.:||..|:.|.:|..:.:|...|     ..::|:|...:.::...|..:.||
Zfish   659 ---IDEQIKEREAERCQEDEDEDKTSPAKAEDV-----PFRQKVDMRARFEQMAKAREEEQK--- 712

  Fly  5187 ADVVPEKISEEKVAEIK-TPEPMDSKAKSKPDGLPADEKSHGAKVSESVPVKNEAEKTDQLSAKK 5250
                 .||.|:|:..:: ..:.:|:..:.|.|   .:|:..|:.::.|...::|
Zfish   713 -----RKIEEQKLQRMQFEQQEIDAALQKKKD---EEEEEEGSIINGSAAYEDE----------- 758

  Fly  5251 PTVLDEDLVVPKRKPYLAEQTADSISLQTYKSMDSEYKDRKESRSAK---RKPTVDIQLTNRNTA 5312
                 ||                                  .:||..   :||     |.|::..
Zfish   759 -----ED----------------------------------HARSGAPWFKKP-----LKNQSVV 779

  Fly  5313 SGSDLKLTCGLSGH-EMNVQWFKDNCPIENGAKYRRTLNDGLSCLEIKSAELGDSGIYRCIASNQ 5376
            ....::.|..::|. :..|.|:.:..|:.:...|:........||.:......|.|.|.|.|.|.
Zfish   780 DAEPVRFTVKITGEPKPEVTWWFEGEPLPDSEDYQYIERGETYCLYLPETFPEDEGEYMCKAVNS 844

  Fly  5377 NGEVETSCLVTI 5388
            .|...::|::||
Zfish   845 RGTAASTCILTI 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strn-Mlck	NP_001261019.1	IG_like	51..127	CDD:214653
		Ig	<69..>112	CDD:299845
		I-set	137..226	CDD:254352
		I-set	235..314	CDD:254352
		Ig_2	244..314	CDD:290606
		I-set	438..513	CDD:254352
		Ig	454..510	CDD:143165
		I-set	537..626	CDD:254352
		Ig	555..618	CDD:299845
		I-set	636..713	CDD:254352
		Ig	652..712	CDD:143165
		SMC_N	<2190..2854	CDD:280601
		I-set	5300..5388	CDD:254352	19/88 (22%)
		IGc2	5313..5378	CDD:197706	14/65 (22%)
		IG	5412..5482	CDD:214652
		IGc2	5413..5481	CDD:197706
		I-set	5542..5627	CDD:254352
		Ig	5556..5621	CDD:143165
		Ig	5654..5721	CDD:143165
		I-set	5784..5874	CDD:254352
		IGc2	5797..5864	CDD:197706
		I-set	5887..5970	CDD:254352
		Ig	5902..5966	CDD:143165
		I-set	5997..6086	CDD:254352
		Ig	6026..6083	CDD:143165
		I-set	6097..6187	CDD:254352
		Ig	6114..6187	CDD:299845
		FN3	6216..6310	CDD:238020
		I-set	6321..6412	CDD:254352
		Ig	6328..6412	CDD:299845
		I-set	6442..6531	CDD:254352
		Ig	6459..6528	CDD:143165
		I-set	6541..6632	CDD:254352
		IGc2	6555..6622	CDD:197706
		I-set	6662..6754	CDD:254352
		Ig	6679..6751	CDD:143165
		I-set	6779..6868	CDD:254352
		IGc2	6793..6858	CDD:197706
		Ig	6938..7022	CDD:299845
		I-set	6939..7028	CDD:254352
		IG	7075..7140	CDD:214652
		Ig	7075..7140	CDD:143165
		IG	7167..7239	CDD:214652
		Ig	7173..7239	CDD:143165
		Ig	7392..7475	CDD:299845
		IG	7406..7475	CDD:214652
		FN3	7489..7588	CDD:238020
		S_TKc	7620..7876	CDD:214567
		STKc_MLCK	7626..7876	CDD:271005
nexn	NP_001077324.2	I-set	767..856	CDD:254352	20/93 (22%)
nexn	NP_001077324.2	Ig	784..851	CDD:143165	15/66 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580317
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930