DRSC/TRiP Functional Genomics Resources

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Protein Alignment Strn-Mlck and mylka

DIOPT Version :9

Sequence 1:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster
Sequence 2:XP_009302720.1 Gene:mylka / 569510 ZFINID:ZDB-GENE-030131-8207 Length:1857 Species:Danio rerio


Alignment Length:2164 Identity:552/2164 - (25%)
Similarity:864/2164 - (39%) Gaps:489/2164 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  5951 KDSGIYW-----CVARNEGAENKISH----QVDFKGRQHYS---LEKTHGFFHRDPNKPHFLLPL 6003
            :|||: |     |...|:...:...|    .|.|....|.|   |....|...::|  |.|.||.
Zfish    30 RDSGV-WTRSRHCTPVNDTNLHCCLHGMMADVQFVTGSHVSKTALTLGRGSPSKEP--PVFTLPP 91

  Fly  6004 GNQTVCNGGTVAISAEFMETSTPIEVKWLRDRRVVDGPNVKALAD--RGVYTLTIMNAGPEVEGT 6066
            .|..||.|||..:..:......| :|.|.|:.:::...:..::..  ||.::|.:........|.
Zfish    92 RNTRVCQGGTARLEGKVRGFPEP-QVCWFRNGKLLIAGDHYSMEQSVRGTFSLVVQEVEDADGGR 155

  Fly  6067 YTCRASNAFGRIESNVNVDV------------------AVGAEK--------DERPPLFLSRPDT 6105
            |||.|.|..|..:..|.:.|                  ::||..        .|.||.|:::| :
Zfish   156 YTCEAVNDAGSCQVTVEIIVEGNTGKKYSLPSTNRTGRSMGAPAVENRASIWGESPPKFVAKP-S 219

  Fly  6106 EMKIAVGDPFSLSFRIAGDPKPKLTFMKGTKDITQSDRVSKEVSDDYTRFSVQQAQISDSGTYFV 6170
            .:.:.||.....|.:|.|.|:|.:.:.||.:.|.|||.        |..|       ..||.:|:
Zfish   220 RLYLKVGQTGKFSAKITGRPQPLVQWYKGEEMIQQSDH--------YNMF-------ERSGMHFL 269

  Fly  6171 VARNNFGTDRIFVTVTVNPRARSATPTQPRWGLPLDSYSDTSYFRDPPGCISTEPLVVDSGPTHI 6235
            ..||.|..|....|..|...|..|:                          :...|::..|.|. 
Zfish   270 EIRNVFSEDAGMYTCLVANSAGKAS--------------------------AAAELIMQDGDTE- 307

  Fly  6236 SLSWGKPVSANSAPVMAYKVEAWVVGHEGGAYWRELGLTPINSFDAFNLKPNVEYHFRVTPKNRY 6300
            ::...|| |.|.:.....|..:..:.:|     ::...|.|.:.                     
Zfish   308 TVIMAKP-SHNPSKSFMLKDTSNTLANE-----QKTSSTSIETI--------------------- 345

  Fly  6301 GWGPTVQTSSPLQVGGVECLPEFVKILPGQAKALLGSSFTLQCNMRGAPRPQVTWFKDGIQLS-- 6363
                ..:|.:||....|..:|...:          |.:..:..::...|..:.|   ||...:  
Zfish   346 ----ITETPTPLSTTTVPTVPSMNR----------GETTIVTSSLHSQPISRST---DGRSATGQ 393

  Fly  6364 SSSERVKIRQIGSTCALTIATVSELDSGRYTCEATNSKGRVSTFARLQVVSDSRIYEADSRLKEI 6428
            ::|..|.:|...|....|..|...|...|...:...|.         |:.|.:|....::|:   
Zfish   394 NTSNLVNLRSQNSVKNETHGTKRVLGMFRAPGQMPQSS---------QIESSTRQQTKETRM--- 446

  Fly  6429 AHGRNVADVGDSLPIFTMRLRDRRVQVTYPVRLTCQIVGYPVPEILWYKDDELIHTDRKHLISAE 6493
                   ||.::.|.|..:.:.:.|.....|...||:.|.|||.:.|.||...:..........|
Zfish   447 -------DVLETPPSFDSQPQSQEVLQGEKVTFKCQVSGSPVPAVSWLKDGAPLRQRSDVSTRQE 504

  Fly  6494 GQFFTLEIAATTLDDSGTYTCLARNELGSVSCHCTLVVDKGIRAYISPDFYVPLDPFYIFREGSE 6558
            .....|.:....:.|:|.|.|.|.|..|:.:.|.:|.| |.:|....|..:..........||.|
Zfish   505 AGLHVLCLDNAHITDTGQYGCTAANRRGNTAAHWSLTV-KRVRVDAKPPVFSSALKDCSVCEGQE 568

  Fly  6559 IRLSTKVEAYPSVGVTWHRNGMRLRPSRRLTATLDSNGYVELIIAEATVRDAGIYVCVASNVVGK 6623
            ..|...||..|...::|..|...:..|.    |:..|...:|.:..|.:.|||:|.|||.|..|:
Zfish   569 FTLQCSVEGKPQPELSWLHNDKPIPFSH----TMFDNSKAQLRVQAAVLEDAGVYSCVAVNEHGR 629

  Fly  6624 VETICRVAVEEAE--NKAVAPQRSLEIPSIKTDDLPYSKEPLFVVKPRSSEAYEGDNVIIFCEVV 6686
            ......|.|:...  .::.||         ...||..:..|||:...:.....:|..||:..||.
Zfish   630 AVCTAHVLVKARPRVKRSAAP---------PVTDLRRTSAPLFLKGLQDLRVMDGSQVIMTVEVT 685

  Fly  6687 GDPKPEVVWLRDFLNPEYYKDAPHFRRIGDGPEYRLEIPSAKLDFTGTYSVIASNCHGEAKAVIS 6751
            |:|.||||||.:....:..:|. ||.:  .|.:|.|.|.....:.||||:....|..|.|:...|
Zfish   686 GNPAPEVVWLHNGKEIQESEDF-HFEK--KGGQYTLFIQEVFPEDTGTYTCEVWNEAGNARTQAS 747

  Fly  6752 LQIFAKDILNKSRMDKVHTRHGNIETLPRFVRNLRNLRCCDGDAISLECHVEADPEPFIIWEKDG 6816
            |.:       :...|.|.         |.|:...::.....|....|.|.:..||.|..:|.|||
Zfish   748 LTV-------QEPQDGVQ---------PWFITKTKSSTASLGQHALLSCAIAGDPFPEFLWMKDG 796

  Fly  6817 HVMPSDRDYVMSFDGTKATLSIPRVYPEDEGEYTCVAKNSVGRSLSSACIIV--------DVPEE 6873
            .|:..|.|:.:.......:|.|.:|.....|.|....||.||...|.|.:.|        |...:
Zfish   797 QVISGDGDFEILQKEDVVSLLIRKVAMHHAGNYEIHLKNKVGECRSVATLHVSEDPMLSADDANK 861

  Fly  6874 KENMLSRQLAR------PSGLLSAHSTPRSTPRSTPARSFSPLR--LSYRTSSIDLSGVAERRRS 6930
            :..:....|.|      ||...|.||...|:............|  |..|..:      .|.|..
Zfish   862 RRGVEKTALGRGGQPKTPSPAASLHSEEHSSGTDQQEEEGGSTRGLLKRRVET------KEHRED 920

  Fly  6931 DARNAITAPKFLAIPYNRVVEEGDSVRFQCAISGHPTPWATWDKDGLIVTPTPRIAVKEI--DDL 6993
            ..|.                :|.:.:.|:..:.                   .::..|.:  :||
Zfish   921 QIRQ----------------QEAEQIDFRTVLG-------------------RKVTTKSVSEEDL 950

  Fly  6994 RIIEIDEVTFDDAGLYR----VTLENDFGRIEATARLD----VIRSSRYSKSPSVRSVRASSSRR 7050
            :.|..:::.| ...|.|    .|...:..::....::|    :.:.:.....|:..|::...|:.
Zfish   951 KEITAEQMDF-RGNLQRQIKPKTQTEEQRKVNTPQQVDFRAVLGKKASQGPKPAPGSLKTQPSKN 1014

  Fly  7051 NAHLYRRIMG----PSTAIGGRMALASGYRGSSVPSVRFYHNDVELEASERVHILLQDSMALLIV 7111
            .|..:|.::|    |.|         ....|.|....|...|||.                  .|
Zfish  1015 EAVDFRSVLGNKKKPPT---------QDRNGESQGDPRGKENDVN------------------CV 1052

  Fly  7112 DNVTREDEGQYTCIISGDHDPLITSTTVTFHDSNTEIRRRRAVITERLPEITKSLEGEVIDLCCS 7176
            |...:|     |...:|..:|                     |..|:|.::| .|:||.:.|.|.
Zfish  1053 DGEIKE-----TTKAAGKKEP---------------------VFVEKLSDVT-VLDGERLHLQCQ 1090

  Fly  7177 IECDEPYSYVWLRNGEILPDSDEFNYIDHGNGRLCLRINDAFDIDSGIYSCQVFTSDINDSTSDS 7241
            :..:.|....|:.:|:::..| :|..|.:...|..|.|:.|...|.|.|.|:..|.:        
Zfish  1091 LSSESPAKVTWMLDGKVIRPS-KFIIITNEGDRYSLSIDKALPEDEGQYVCRAETDE-------- 1146

  Fly  7242 TFDSHSICSLINSGCSDCSSSGELCVLERDLRGQDEECVQLLKTPLPVVCASGDEALFYARVFPC 7306
                         |.::||                  ||.|:..|                    
Zfish  1147 -------------GKTECS------------------CVVLVNDP-------------------- 1160

  Fly  7307 DAEADWYLNGQLLAQADDSLNMTLESYPENGIRLLRMRDVTASRSGEICLQVKHPQAEFRRIPTT 7371
                       .::..||                        .||.:........:|:.:: |..
Zfish  1161 -----------SVSTPDD------------------------KRSRKPSTPTTENEAKIKK-PPP 1189

  Fly  7372 RTYTSLLVLPAIRGNSSSSSLAARSCILTRPEDCTALIGGHVRLSVRYEPFPGTKVIWYKACHPI 7436
            :|.......|.|:               ..|:|...:.|..|.|..::.........|.|...||
Zfish  1190 KTLPKQGAPPQIQ---------------QFPDDMKIMAGQEVILQCKFTGALPISCTWLKFRKPI 1239

  Fly  7437 VESSNVTIRTTSQQSTLYITDISADDSGKYTVEVMNDYGVEAAAASVAVEGPPEPPSGQPSVS-L 7500
            .|...::|.:|...|.|.||:...:..|.||:|:.|.:||..||.::.:...|:||:..|:.| :
Zfish  1240 QEGQGISIVSTDSSSQLTITEGQQEHCGCYTIEIKNSFGVRQAALNLTIVDKPDPPARVPAASDI 1304

  Fly  7501 GPDRVAVAWCGPPYDGGCMITGFIIEMQTIGDENCDEDSWQQVTRVVDSLAYTVKNLQPERQYRF 7565
            ....:.::|.||.||||..:..:.:|..     |..:..|..|.. .:|.:|.|::|.|:|||:|
Zfish  1305 RKSSLTLSWYGPTYDGGSAVQSYNLEAW-----NSLDMKWTDVAS-CNSTSYNVQDLLPDRQYKF 1363

  Fly  7566 RVRAENIHGRSAPGQASELVQI-------TNTPQRSTSSDASDRF-GQATVSVQSGGDFKSRFEI 7622
            ||||.||:|...|...||.||:       ....:...|.|.|::. ....|::::....|..:::
Zfish  1364 RVRAVNIYGVGEPSAESEPVQVGLEAEGENKEDEVEPSDDESEKVPDYRNVTIKTDVKVKDFYDV 1428

  Fly  7623 IEELGKGRFGIVYKVQERGQPEQLLAAKVIKCIKSQDRQKVLEEISIMRALQHPKLLQLAASFES 7687
            .:.||.|:||.|:|:.|: ..:::.|.|.||...:::::.|.:||:||..|.||||:|...:||.
Zfish  1429 EDRLGTGKFGTVFKLIEK-STKKVWAGKFIKAYSAKEKENVRQEIAIMNDLHHPKLVQCIDAFEG 1492

  Fly  7688 PREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDGVAYMHGQSVVHLDLKPENIMCHT 7752
            ..:||||:|.|:|||||:|::.:||.|||.:.|.::.|:.|||.::|.:.:||||||||||||..
Zfish  1493 KTDIVMVLEMISGGELFDRIIDEDFELTEREVIKYMLQIVDGVNFIHKKGIVHLDLKPENIMCVN 1557

  Fly  7753 RTSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQSDMWSVGVICYVLLSGLSP 7817
            :|..:||:||||||:||:....::||||||||:.||:|:||.|.:.:||||:|||||:|:|||||
Zfish  1558 KTGSKIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEAISYATDMWSIGVICYILVSGLSP 1622

  Fly  7818 FMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVHRKEDRLTAQQCLASKWLSQRPDD 7882
            ||||.|.||.||:|.|.:|::|||||.:|:|||||||.||....:.|||..||....||.| ...
Zfish  1623 FMGDNDNETLSNVTSATWDFEDEAFDEISEEAKDFISNLLKKDMKARLTCDQCFQHPWLKQ-DTT 1686

  Fly  7883 SLSNNKICTDKLKKFIIRRKWQKTGNAIRALGRMANLSVSRRNSAIAMGV---LSSP-------- 7936
            ::...|:..:::||:|:||||||||:|:||:||::|:       |:..||   .|||        
Zfish  1687 NMEAKKLSKERMKKYILRRKWQKTGHAVRAIGRLSNM-------ALMAGVHAKKSSPTEADAKQF 1744

  Fly  7937 ----------RPSISGLGMLTTSAIGSGTSSQMTSLHEEEDD-----FSGEMPPVEKRTVLKLRD 7986
                      :|:.|  .::....:..|::::.....|...|     :..:.|..|.|       
Zfish  1745 AAELEAKTLMKPTFS--SVIKDVEVVEGSAARFDCKIEGYPDPEVVWYKDDQPIKETR------- 1800

  Fly  7987 KSQCSERSDSGYSECSNCS 8005
                  .....|.|..|||
Zfish  1801 ------HFQIDYDEDGNCS 1813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Strn-MlckNP_001261019.1 IG_like 51..127 CDD:214653
Ig <69..>112 CDD:299845
I-set 137..226 CDD:254352
I-set 235..314 CDD:254352
Ig_2 244..314 CDD:290606
I-set 438..513 CDD:254352
Ig 454..510 CDD:143165
I-set 537..626 CDD:254352
Ig 555..618 CDD:299845
I-set 636..713 CDD:254352
Ig 652..712 CDD:143165
SMC_N <2190..2854 CDD:280601
I-set 5300..5388 CDD:254352
IGc2 5313..5378 CDD:197706
IG 5412..5482 CDD:214652
IGc2 5413..5481 CDD:197706
I-set 5542..5627 CDD:254352
Ig 5556..5621 CDD:143165
Ig 5654..5721 CDD:143165
I-set 5784..5874 CDD:254352
IGc2 5797..5864 CDD:197706
I-set 5887..5970 CDD:254352 6/23 (26%)
Ig 5902..5966 CDD:143165 6/19 (32%)
I-set 5997..6086 CDD:254352 25/90 (28%)
Ig 6026..6083 CDD:143165 14/58 (24%)
I-set 6097..6187 CDD:254352 26/89 (29%)
Ig 6114..6187 CDD:299845 21/72 (29%)
FN3 6216..6310 CDD:238020 12/93 (13%)
I-set 6321..6412 CDD:254352 15/92 (16%)
Ig 6328..6412 CDD:299845 14/85 (16%)
I-set 6442..6531 CDD:254352 24/88 (27%)
Ig 6459..6528 CDD:143165 20/68 (29%)
I-set 6541..6632 CDD:254352 25/90 (28%)
IGc2 6555..6622 CDD:197706 22/66 (33%)
I-set 6662..6754 CDD:254352 32/91 (35%)
Ig 6679..6751 CDD:143165 26/71 (37%)
I-set 6779..6868 CDD:254352 26/88 (30%)
IGc2 6793..6858 CDD:197706 20/64 (31%)
Ig 6938..7022 CDD:299845 10/89 (11%)
I-set 6939..7028 CDD:254352 11/98 (11%)
IG 7075..7140 CDD:214652 12/64 (19%)
Ig 7075..7140 CDD:143165 12/64 (19%)
IG 7167..7239 CDD:214652 19/71 (27%)
Ig 7173..7239 CDD:143165 17/65 (26%)
Ig 7392..7475 CDD:299845 21/82 (26%)
IG 7406..7475 CDD:214652 19/68 (28%)
FN3 7489..7588 CDD:238020 37/106 (35%)
S_TKc 7620..7876 CDD:214567 132/255 (52%)
STKc_MLCK 7626..7876 CDD:271005 132/249 (53%)
mylkaXP_009302720.1 I-set 85..175 CDD:254352 25/90 (28%)
Ig 91..165 CDD:299845 19/74 (26%)
I-set 212..300 CDD:254352 29/129 (22%)
Ig 231..301 CDD:299845 25/110 (23%)
PHA03255 283..>461 CDD:165513 42/267 (16%)
Ig 452..541 CDD:299845 23/88 (26%)
I-set 453..542 CDD:254352 24/88 (27%)
I-set 552..638 CDD:254352 24/89 (27%)
IGc2 565..628 CDD:197706 22/66 (33%)
I-set 661..750 CDD:254352 32/91 (35%)
Ig 678..747 CDD:143165 26/71 (37%)
I-set 759..848 CDD:254352 26/88 (30%)
Ig 762..846 CDD:299845 24/83 (29%)
I-set 1068..1157 CDD:254352 30/150 (20%)
Ig 1087..1152 CDD:143165 18/86 (21%)
Ig8_MLCK 1199..1296 CDD:143239 29/111 (26%)
I-set 1199..1288 CDD:254352 27/103 (26%)
FN3 1292..1381 CDD:238020 33/94 (35%)
STKc_MLCK1 1423..1681 CDD:271093 133/258 (52%)
Pkinase 1426..1681 CDD:278497 132/255 (52%)
I-set 1756..1846 CDD:254352 13/73 (18%)
IGc2 1769..1836 CDD:197706 11/58 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007119
OrthoInspector 1 1.000 - - otm25795
orthoMCL 1 0.900 - - OOG6_104679
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4882
SonicParanoid 1 1.000 - - X3431
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.840

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