DRSC/TRiP Functional Genomics Resources

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Protein Alignment Strn-Mlck and MYLK

DIOPT Version :9

Sequence 1:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster
Sequence 2:XP_024309300.1 Gene:MYLK / 4638 HGNCID:7590 Length:1924 Species:Homo sapiens


Alignment Length:2295 Identity:556/2295 - (24%)
Similarity:869/2295 - (37%) Gaps:628/2295 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  5880 EAPLPSTFTQPIRDTYSLNENELVLDCRVRGQPRPEIQWIKGTEPIEASEKFKPSDQADGYAKLV 5944
            |||   .|..|.|:...........:.||||.|.|::.|.:..:||.:..:|.......|...||
Human    41 EAP---AFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSGGRFLLDCGIRGTFSLV 102

  Fly  5945 IVNPTEKDSGIYWCVARNEGAENKISHQVDFKGRQHYSLEKTHGFFHRDPNKPHFLLPLGNQTVC 6009
            |....|:|.|.|.|.|.|.....:::.::..:|                    .|...||...|.
Human   103 IHAVHEEDRGKYTCEATNGSGARQVTVELTVEG--------------------SFAKQLGQPVVS 147

  Fly  6010 NGGTVAISAEFMETSTPIEVKWLRDRRVVDGPNVKALADRGVYTLTIMNAGPEVEGTYTCRASNA 6074
                                              |.|.||  ::...:...|.:.|         
Human   148 ----------------------------------KTLGDR--FSAPAVETRPSIWG--------- 167

  Fly  6075 FGRIESNVNVDVAVGAEKDERPPLFLSRPDTEMKIAVGDPFSLSFRIAGDPKPKLTFMKGTKDIT 6139
                               |.||.|.::.. .:.:..|.....|.:|.|.|:|::|::||...:.
Human   168 -------------------ECPPKFATKLG-RVVVKEGQMGRFSCKITGRPQPQVTWLKGNVPLQ 212

  Fly  6140 QSDRVSKEVSDDYTRFSVQQAQISDSGTYFVVARNNFG---------------TDRIFV--TVTV 6187
            .|.|||....:......:......|.|.|..:..|..|               .:|.||  |...
Human   213 PSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMSAELSIQGLDSANRSFVRETKAT 277

  Fly  6188 NPRARSATPTQPRWGLPLDSYSDTSYFRD---------PPGCISTEPLVVDSGPTHISLSWGK-- 6241
            |...|............|||....:..::         ||...:::|    ..|....|...|  
Human   278 NSDVRKEVTNVISKESKLDSLEAAAKSKNCSSPQRGGSPPWAANSQP----QPPRESKLESCKDS 338

  Fly  6242 PVSANSAPVM-----AYKVEAWVVGHEGGAYWRELGLTPINSFDAFNLKPNVEYHFRVTPKNRYG 6301
            |.:|...||:     :..::|..|..|..|  ..||:          |.|:.|...|..|. |..
Human   339 PRTAPQTPVLQKTSSSITLQAARVQPEPRA--PGLGV----------LSPSGEERKRPAPP-RPA 390

  Fly  6302 WGPTVQTS--------------SPLQVGGVECLPEFVKILPGQAKALLGSSFTLQCNMRGAPRPQ 6352
            ..||.|..              .|::.......|:| :..|...:.....:...:|.:.|.|:|:
Human   391 TFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKF-ESKPQSQEVKENQTVKFRCEVSGIPKPE 454

  Fly  6353 VTWFKDGIQLSSSSERVKIRQIGSTCALTIATVSELDSGRYTCEATNSKGRVSTFARLQVVSDSR 6417
            |.||.:|..:......:::.:...:..|.:......|||.|:|.|:|::|::|....|||   .|
Human   455 VAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTRDSGTYSCTASNAQGQLSCSWTLQV---ER 516

  Fly  6418 IYEADSRLKEIAHGRNVADVGDSLPIFTMRLRDRRVQVTYPVRLTCQIVGYPVPEILWYKDDELI 6482
            :     .:.|:|            |.|:..|:|..|.......|.|.:.|.|||.|.|..:.:.|
Human   517 L-----AVMEVA------------PSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI 564

  Fly  6483 HTDRKHLISAEGQFFTLEIAATTLDDSGTYTCLARNELGSVSCHCTLVVDKGIRAYISPDFYVPL 6547
            ...|.   :.|.....|.|.....:|.|||||||.|.||.|||...:.|.:. ::....::.:|:
Human   565 QYARS---TCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEK-KSSRKSEYLLPV 625

  Fly  6548 DPFY----IF---------REGSEIRLSTKVEAYPSVGVTWHRNGMRLRPSRRLTATLDSNG-YV 6598
            .|..    ||         .:||::.::.:|...|...|.|..||..::.|...  ..:..| ..
Human   626 APSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDF--HFEQRGTQH 688

  Fly  6599 ELIIAEATVRDAGIYVCVASNVVGKVETICRVAVEEAENKAVAPQRSLEIPSIKTDDLPYSKEPL 6663
            .|.|.|....|.|.|.|.|.|..|:|.|...:.|:|..:                     ..:|.
Human   689 SLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHD---------------------GTQPW 732

  Fly  6664 FVVKPRSSEAYEGDNVIIFCEVVGDPKPEVVWLRDFLNPEYYKDAPHFRRIGDGPEYRLEIPSAK 6728
            |:.||||..|..|.:|:|.|.:.|||.|.|.||||  .....||..||..:.:...:.|.:...:
Human   733 FISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRD--GKALCKDTGHFEVLQNEDVFTLVLKKVQ 795

  Fly  6729 LDFTGTYSVIASNCHGEAKAVISLQIFAKDILNKSRMDKVHTRHGNIETLPRFVRNLRNLRCCDG 6793
            ....|.|.::..|..||....:||.:                ::.:...|||             
Human   796 PWHAGQYEILLKNRVGECSCQVSLML----------------QNSSARALPR------------- 831

  Fly  6794 DAISLECHVEADPEPFIIWEKDGHVMPSDRDYVMSFDGTKATLSIPRVYPEDEGEYTCVAKNSVG 6858
                                                                            |
Human   832 ----------------------------------------------------------------G 832

  Fly  6859 RSLSSACIIVDVPEEKENMLSRQLARPSGLLSAHSTPRSTPRSTPARSFSPLRLSYRTSSIDLSG 6923
            |.          |...|::....:....|....:.:.|.   ..|||....|.   .....|:.|
Human   833 RE----------PASCEDLCGGGVGADGGGSDRYGSLRP---GWPARGQGWLE---EEDGEDVRG 881

  Fly  6924 VAERR---RSDARNAITAPKFLAIPYNRVVEEGDSVRFQCAISGHPTPWATWDKDGLIVTPTPRI 6985
            |.:||   |.....||..            :|.:.:.|:..:.                   .::
Human   882 VLKRRVETRQHTEEAIRQ------------QEVEQLDFRDLLG-------------------KKV 915

  Fly  6986 AVKEI--DDLRIIEIDEVTFDDAGLYR----VTLENDFGRIEATARLDVIRSSRYSKSPSVRSVR 7044
            :.|.:  |||:.|..:::.| .|.|.|    .|:..:..::.:..::|            .|||.
Human   916 STKTLSEDDLKEIPAEQMDF-RANLQRQVKPKTVSEEERKVHSPQQVD------------FRSVL 967

  Fly  7045 ASSSRRNAHLYRRIMGPSTA-------IGGRMALASGYRGSSVPSVRFYHNDVELEASERVHILL 7102
            |........:..::..|..|       :||:..|.:....||..::    |...:|:|:.:. ..
Human   968 AKKGTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETL----NAKAVESSKPLS-NA 1027

  Fly  7103 QDSMALLIVDNV-----------------------TREDEGQYTCI-------ISGDHDPLITST 7137
            |.|..|..|.|.                       .:.||...:..       :..|.:......
Human  1028 QPSGPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHA 1092

  Fly  7138 TVTFHDSNTEIRRRRAVITERLPEITKSLEGEVIDLCCSIECDEPYSYVWLRNGEILPDSDEFNY 7202
            ..|.::..:|.:.......::|.::..: ||:.:.|.|.:..|.|.:.:|..||:.| .:.:|..
Human  1093 GTTDNEKRSESQGTAPAFKQKLQDVHVA-EGKKLLLQCQVSSDPPATIIWTLNGKTL-KTTKFII 1155

  Fly  7203 IDHGNGRLC-LRINDAFDIDSGIYSCQVFTSDINDSTSDSTFDSHSICSLINSGCSDCSSSGELC 7266
            :.. .|.|| :.|..|...|.|:|.| |..:|                    :|.::||      
Human  1156 LSQ-EGSLCSVSIEKALPEDRGLYKC-VAKND--------------------AGQAECS------ 1192

  Fly  7267 VLERDLRGQDEECVQLLKTPLPVVCASGDEALFYARVFPCDAEADWYLNGQLLAQADDSLNMTLE 7331
                                                   |....|                    
Human  1193 ---------------------------------------CQVTVD-------------------- 1198

  Fly  7332 SYPENGIRLLRMRDVTASRSGEICLQVKHPQAEFRRIPTTRTYTSLLVLPAIRGNSSSSSLAARS 7396
                         |..||.:      .|.|:.:.||..::        ||.:.|..|.:::..:.
Human  1199 -------------DAPASEN------TKAPEMKSRRPKSS--------LPPVLGTESDATVKKKP 1236

  Fly  7397 C------------ILTRPEDCTALIGGHVRLSVRYEPFPGTKVI---WYKACHPIVESSNVTIRT 7446
            .            |:..|||.....|..|.|   :....||:.|   |.|....|.||.::.:..
Human  1237 APKTPPKAAMPPQIIQFPEDQKVRAGESVEL---FGKVTGTQPITCTWMKFRKQIQESEHMKVEN 1298

  Fly  7447 TSQQSTLYITDISADDSGKYTVEVMNDYGVEAAAASVAVEGPPEPPSGQPSVS-LGPDRVAVAWC 7510
            :...|.|.|.....:..|.||:.|.|..|...|..::.|...|:||:|.|..| :....:.::|.
Human  1299 SENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWY 1363

  Fly  7511 GPPYDGGCMITGFIIEMQTIGDENCDEDSWQQVTRVVDSLAYTVKNLQPERQYRFRVRAENIHGR 7575
            |..||||..:..:.||:....::     :|:::. ...|.::.|::|.|:.:|:|||||.|::|.
Human  1364 GSSYDGGSAVQSYSIEIWDSANK-----TWKELA-TCRSTSFNVQDLLPDHEYKFRVRAINVYGT 1422

  Fly  7576 SAPGQASELVQITNTPQR-------STSSDASDRFGQATVSVQSGGDFKSRFEIIEELGKGRFGI 7633
            |.|.|.|||..:...|:.       |...:........||::.:.......::|.|.||.|:||.
Human  1423 SEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQ 1487

  Fly  7634 VYKVQERGQPEQLLAAKVIKCIKSQDRQKVLEEISIMRALQHPKLLQLAASFESPREIVMVMEYI 7698
            |:::.|: :..::.|.|..|...:::::.:.:|||||..|.||||:|...:||....||||:|.:
Human  1488 VFRLVEK-KTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIV 1551

  Fly  7699 TGGELFERVVADDFTLTEMDCILFLRQVCDGVAYMHGQSVVHLDLKPENIMCHTRTSHQIKIIDF 7763
            :|||||||::.:||.|||.:||.::||:.:||.|:|.|.:||||||||||||..:|..:||:|||
Human  1552 SGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDF 1616

  Fly  7764 GLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQSDMWSVGVICYVLLSGLSPFMGDTDVETFS 7828
            |||:||:....::||||||||:.||:|:|||||:.:||||:|||||:|:|||||||||.|.||.:
Human  1617 GLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLA 1681

  Fly  7829 NITRADYDYDDEAFDCVSQEAKDFISQLLVHRKEDRLTAQQCLASKWLSQRPDDSLSNNKICTDK 7893
            |:|.|.:|:||||||.:|.:||||||.||....::||...|||...|| .:...::...|:..|:
Human  1682 NVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL-MKDTKNMEAKKLSKDR 1745

  Fly  7894 LKKFIIRRKWQKTGNAIRALGRMANLSVSRRNSAIAMGVLSSPRPSISGLGMLTTSAIGSGTSSQ 7958
            :||::.||||||||||:||:||::::::                  ||||.. ..|:.||.||..
Human  1746 MKKYMARRKWQKTGNAVRAIGRLSSMAM------------------ISGLSG-RKSSTGSPTSPL 1791

  Fly  7959 MTSLHEEEDDFS--------GEMPPVEKRTVLKLRD---------KSQC---------------- 7990
            .....|.|:|.|        .|.|.|:......:||         :..|                
Human  1792 NAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDD 1856

  Fly  7991 -----SERSDSGYSECSNCS 8005
                 |......|.|..|||
Human  1857 QSIRESRHFQIDYDEDGNCS 1876

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Strn-MlckNP_001261019.1 IG_like 51..127 CDD:214653
Ig <69..>112 CDD:299845
I-set 137..226 CDD:254352
I-set 235..314 CDD:254352
Ig_2 244..314 CDD:290606
I-set 438..513 CDD:254352
Ig 454..510 CDD:143165
I-set 537..626 CDD:254352
Ig 555..618 CDD:299845
I-set 636..713 CDD:254352
Ig 652..712 CDD:143165
SMC_N <2190..2854 CDD:280601
I-set 5300..5388 CDD:254352
IGc2 5313..5378 CDD:197706
IG 5412..5482 CDD:214652
IGc2 5413..5481 CDD:197706
I-set 5542..5627 CDD:254352
Ig 5556..5621 CDD:143165
Ig 5654..5721 CDD:143165
I-set 5784..5874 CDD:254352
IGc2 5797..5864 CDD:197706
I-set 5887..5970 CDD:254352 24/82 (29%)
Ig 5902..5966 CDD:143165 21/63 (33%)
I-set 5997..6086 CDD:254352 10/88 (11%)
Ig 6026..6083 CDD:143165 6/56 (11%)
I-set 6097..6187 CDD:254352 24/106 (23%)
Ig 6114..6187 CDD:299845 21/89 (24%)
FN3 6216..6310 CDD:238020 25/123 (20%)
I-set 6321..6412 CDD:254352 22/90 (24%)
Ig 6328..6412 CDD:299845 20/83 (24%)
I-set 6442..6531 CDD:254352 32/88 (36%)
Ig 6459..6528 CDD:143165 27/68 (40%)
I-set 6541..6632 CDD:254352 26/104 (25%)
IGc2 6555..6622 CDD:197706 19/67 (28%)
I-set 6662..6754 CDD:254352 32/91 (35%)
Ig 6679..6751 CDD:143165 22/71 (31%)
I-set 6779..6868 CDD:254352 4/88 (5%)
IGc2 6793..6858 CDD:197706 0/64 (0%)
Ig 6938..7022 CDD:299845 12/89 (13%)
I-set 6939..7028 CDD:254352 12/94 (13%)
IG 7075..7140 CDD:214652 13/94 (14%)
Ig 7075..7140 CDD:143165 13/94 (14%)
IG 7167..7239 CDD:214652 22/72 (31%)
Ig 7173..7239 CDD:143165 20/66 (30%)
Ig 7392..7475 CDD:299845 23/97 (24%)
IG 7406..7475 CDD:214652 19/71 (27%)
FN3 7489..7588 CDD:238020 33/99 (33%)
S_TKc 7620..7876 CDD:214567 136/255 (53%)
STKc_MLCK 7626..7876 CDD:271005 134/249 (54%)
MYLKXP_024309300.1 I-set 43..133 CDD:254352 25/92 (27%)
I-set 171..260 CDD:254352 20/89 (22%)
23ISL 261..422 CDD:318761 35/177 (20%)
I-set 424..514 CDD:254352 22/90 (24%)
I-set 524..610 CDD:254352 32/88 (36%)
I-set 633..722 CDD:254352 24/90 (27%)
I-set 731..819 CDD:254352 30/89 (34%)
I-set 1108..1197 CDD:254352 27/157 (17%)
Ig8_hMLCK_like 1248..1345 CDD:143239 28/99 (28%)
FN3 1341..1433 CDD:238020 33/97 (34%)
STKc_MLCK1 1471..1729 CDD:271093 136/258 (53%)
I-set 1819..1909 CDD:254352 9/58 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 301 1.000 Domainoid score I1418
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007119
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_104679
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4882
SonicParanoid 1 1.000 - - X3431
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.840

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