DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strn-Mlck and sqa

DIOPT Version :9

Sequence 1:	NP_001261019.1	Gene:	Strn-Mlck / 36753	FlyBaseID:	FBgn0265045	Length:	8255	Species:	Drosophila melanogaster
Sequence 2:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster

Alignment Length:	816	Identity:	234/816 - (28%)
Similarity:	365/816 - (44%)	Gaps:	208/816 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  7603 FGQATVSVQSGGDFKSRFEIIEELGKGRFGIVYKVQERGQPEQLLAAKVIKCIKSQDRQKVLEEI 7667
            |....|::....|....::::.|:|:|:||.|||.:::....| ||||.:...|.:|::.|..|:
  Fly    17 FPMRDVTINRNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQ-LAAKFVPIPKREDKRNVEREV 80

  Fly  7668 SIMRALQHPKLLQLAASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDGVAY 7732
            .||.:|||..::||.|::|..:.:.:|:|.|.|||||:|||.|:|.|||..|.:|:||||:.:|:
  Fly    81 EIMNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAF 145

  Fly  7733 MHGQSVVHLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGF 7797
            :||..:||||||||||:..|:..::|||||||||::.|....:|||||||||:.||:::::.|.:
  Fly   146 IHGNGIVHLDLKPENILVLTQKGNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFDCISY 210

  Fly  7798 QSDMWSVGVICYVLLSGLSPFMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVHRKE 7862
            .:||||||||||||:||||||||:.|:||.||:|.|.||::||.|:.:|.|..|||::||.....
  Fly   211 GTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLAKDLS 275

  Fly  7863 DRLTAQQCLASKWLSQRP----------------------------------------------- 7880
            .|:||.:|:..|||.|||
  Fly   276 TRMTAAECMKHKWLQQRPATAATATPITKAASAASKSRLKSVSPVTAPSESSEDSTETIEDEDDE 340

  Fly  7881 ---------------DDSLSN--------NK---ICTDKLKKFIIRRKWQK----------TGNA 7909
                           |:.|:|        ||   ...|.||.||:|  |:.          .||.
  Fly   341 EEVAVQQAKQKDQQQDEELANLCGDAELENKELDATKDNLKNFIVR--WETHPNSPYVFDVEGNV 403

  Fly  7910 IRALGRMANLSVSRRNSAIAMGVLSSPRP-SISGLGMLTTSAIGSGTSSQMTSLHEEEDDFSGEM 7973
            |..|..                 .|.|.| ...|...|::|.:.|  .|...|:....||..|::
  Fly   404 IAPLSE-----------------TSYPHPRRTHGADSLSSSRVCS--PSPCDSISTLTDDERGDI 449

  Fly  7974 PPVEKRTVLKLRDKSQCSERSDSGYSECSNCSGAQETLLLSLAKSKLEAIAKASTLPTVVH---- 8034
            ..:.:      .|:|:.:| ::|..|..:..:.::|.|..::|.|       :.:.||..|
  Fly   450 EDLPE------EDESRSAE-NESPRSVATPINESREKLFPTVATS-------SPSTPTPQHLFNE 500

  Fly  8035 DTEQPVSLELPTKGEAIMRSDFTNTIKMRKKS----LEDSAAREKPRSKPQVKPL------LCES 8089
            :.::....:...:.:..|:| :.:|...|...    |...::.|:.....:::.|      |.|.
  Fly   501 NFDEFSGSQSTAQQQRSMKS-YLHTFDRRNSDTTYLLGRRSSGERVNLADEIRKLSDHLLMLAEI 564

  Fly  8090 KLKVSQLKDRFQVSPAPASASASASAANKP-PLAYGPFKIAKVASVGRISRTEEPGRSGR----- 8148
            ..|:....:....|.|||...|:|:||..| |.:..|..:|...|..  |:|.|..:.|.
  Fly   565 NTKLGDANNNGSSSGAPADPPAAAAAAAAPVPTSTAPASVAPSGSTS--SKTSEISQEGNRWTSK 627

  Fly  8149 -------GAPSV-------------------SGKGK----SPQVR---SMPSSP----------- 8169
                   ..|::                   .||||    |..||   |:..:|
  Fly   628 TTSSSSWNRPTLKGGLFSQASSSSQSQSTYDDGKGKTKISSLSVRLQQSIEETPKLSNGNSSSSK 692

  Fly  8170 ---LPQRSATPTRLMSQRVREAAERLAQQHTVASAQRHLGNGRGTGTGNGN-------------- 8217
               ..||.:|...:.|...|....:..|:.:..|::....:.|.:.|.:.|
  Fly   693 SLVQSQRKSTVQTMSSSNARSFTNQQVQRTSTTSSKVISSSTRSSNTSSSNYIASNASNSISTSA 757

  Fly  8218 GNSNSNGNGNGNTAETNRES----RARRLINRFNSE 8249
            .|.:|.|..|..|...:.||    ||:..||:.:.:
  Fly   758 SNPSSTGASNPITTSASNESASSRRAKFRINQMSRD 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strn-Mlck	NP_001261019.1	IG_like	51..127	CDD:214653
		Ig	<69..>112	CDD:299845
		I-set	137..226	CDD:254352
		I-set	235..314	CDD:254352
		Ig_2	244..314	CDD:290606
		I-set	438..513	CDD:254352
		Ig	454..510	CDD:143165
		I-set	537..626	CDD:254352
		Ig	555..618	CDD:299845
		I-set	636..713	CDD:254352
		Ig	652..712	CDD:143165
		SMC_N	<2190..2854	CDD:280601
		I-set	5300..5388	CDD:254352
		IGc2	5313..5378	CDD:197706
		IG	5412..5482	CDD:214652
		IGc2	5413..5481	CDD:197706
		I-set	5542..5627	CDD:254352
		Ig	5556..5621	CDD:143165
		Ig	5654..5721	CDD:143165
		I-set	5784..5874	CDD:254352
		IGc2	5797..5864	CDD:197706
		I-set	5887..5970	CDD:254352
		Ig	5902..5966	CDD:143165
		I-set	5997..6086	CDD:254352
		Ig	6026..6083	CDD:143165
		I-set	6097..6187	CDD:254352
		Ig	6114..6187	CDD:299845
		FN3	6216..6310	CDD:238020
		I-set	6321..6412	CDD:254352
		Ig	6328..6412	CDD:299845
		I-set	6442..6531	CDD:254352
		Ig	6459..6528	CDD:143165
		I-set	6541..6632	CDD:254352
		IGc2	6555..6622	CDD:197706
		I-set	6662..6754	CDD:254352
		Ig	6679..6751	CDD:143165
		I-set	6779..6868	CDD:254352
		IGc2	6793..6858	CDD:197706
		Ig	6938..7022	CDD:299845
		I-set	6939..7028	CDD:254352
		IG	7075..7140	CDD:214652
		Ig	7075..7140	CDD:143165
		IG	7167..7239	CDD:214652
		Ig	7173..7239	CDD:143165
		Ig	7392..7475	CDD:299845
		IG	7406..7475	CDD:214652
		FN3	7489..7588	CDD:238020
		S_TKc	7620..7876	CDD:214567	128/255 (50%)
		STKc_MLCK	7626..7876	CDD:271005	127/249 (51%)
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	128/255 (50%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	127/249 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31379at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.920