DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strn-Mlck and DIP-theta

DIOPT Version :9

Sequence 1:	NP_001261019.1	Gene:	Strn-Mlck / 36753	FlyBaseID:	FBgn0265045	Length:	8255	Species:	Drosophila melanogaster
Sequence 2:	NP_723103.1	Gene:	DIP-theta / 33795	FlyBaseID:	FBgn0051646	Length:	606	Species:	Drosophila melanogaster

Alignment Length:	665	Identity:	128/665 - (19%)
Similarity:	210/665 - (31%)	Gaps:	243/665 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  6324 VKILPGQAKALLGSSFTLQCNMRGAPRPQVTWFKDGIQLSSSSERVKIRQIGSTCALTIATVSEL 6388
            :||.|     |...:.|:      |.|.|.......:|.......:..|.|.:|....:.::..|
  Fly     3 IKIFP-----LTADAATI------AARRQRRRAAGKLQRKREMPEISSRLIVATATAAVVSIICL 56

  Fly  6389 DSGRYTCEATNS--KGRVSTFARLQ------VVSDSRIYE-----------ADSRLKEIAHGRNV 6434
            ......|.|..|  :|.:....::.      ::.:|..::           .|..|::|.....|
  Fly    57 SLALPGCAAQESDDEGELHHLDQMHHQHQDFIIGESEEHDHIAHHLAEMQNKDELLEDIREDTVV 121

  Fly  6435 ADVGD-SLPIFTMRLRDRRVQVTYPVRLTCQIVGYPVPEILWYK-DDELIHTDRKHLIS------ 6491
            ..:.: .||.|...|::..|.|:....|.|.:......:|.|.: |.:.|.|.:.|:|:
  Fly   122 NAIPEKDLPKFGELLQNVTVPVSREAVLQCVVDNLQTYKIAWLRVDTQTILTIQNHVITKNHRMS 186

  Fly  6492 ---AEGQFFTLEIAATTLDDSGTYTC-LARNELGSVSCHCTLVVDKGIRAYISPDFYVPLDPFYI 6552
               ||.:.:.|.|......|.|.|.| :..:.:.|...:..:||...|..|       |.....:
  Fly   187 ITHAEKRAWILRIRDVKESDKGWYMCQINTDPMKSQVGYLDVVVPPDILDY-------PTSTDMV 244

  Fly  6553 FREGSEIRLSTKVEAYPSVGVTWHRNGMRLRPSRRLTATLDSNGYVELIIAEATVRDAGIYVCVA 6617
            .||||.:.|.......|:..:||.|.|..|.|.......:..||.. |.||:....:.|.|:|:|
  Fly   245 IREGSNVTLKCAATGSPTPTITWRREGGELIPLPNGAEAVAYNGSF-LTIAKVNRLNMGAYLCIA 308

  Fly  6618 SNVVGKVETICRVAVEEAENKAVAPQRSLEIPSIKTDDLPYSKEPLFVVKPRSSEAYEGDNVIIF 6682
            ||.:.                          |::       ||..:.:|.
  Fly   309 SNGIP--------------------------PTV-------SKRVMLIVH--------------- 325

  Fly  6683 CEVVGDPKPEVVWLRDFLNPEYYKDAPHFRRIGDGPEYRLEIPSAKLDFTGTYSVIASNCHGEAK 6747
                   .|.::|:::.|             :|                    :.:..|
  Fly   326 -------FPPMIWIQNQL-------------VG--------------------AALTQN------ 344

  Fly  6748 AVISLQIFAKDILNKSRMDKVHTRHGNIETLPRFVRNLRNLRCCDGDAISLECHVEADPEPFIIW 6812
                                                            |:|||..||.|:....|
  Fly   345 ------------------------------------------------ITLECQSEAYPKSINYW 361

  Fly  6813 EK-DGHVMPSDRDYVMSFD-GTKAT--LSIPRVYPEDEGEYTCVAKNSVGRSLSSACIIVDVPEE 6873
            .| |..::|.:|....:|: |.|.|  |:|..|..:|.|.|.||||||:|.:
  Fly   362 MKNDTIIVPGERFVPETFESGYKITMRLTIYEVDIQDFGAYRCVAKNSLGDT------------- 413

  Fly  6874 KENMLSRQLARPSGLLSAHSTPRSTPRSTPARSFSPLRLSYRTSSIDLSGVA------ERRRSDA 6932
                        .|.:..:..|::|..:|.|          .|.||:...|.      |:|...:
  Fly   414 ------------DGAIKLYHIPQTTTMTTMA----------PTVSINTVPVVLVKYNKEQRYGSS 456

  Fly  6933 RNAITAPKFLAIPYN 6947
            :|:.|.      |||
  Fly   457 QNSNTN------PYN 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strn-Mlck	NP_001261019.1	IG_like	51..127	CDD:214653
		Ig	<69..>112	CDD:299845
		I-set	137..226	CDD:254352
		I-set	235..314	CDD:254352
		Ig_2	244..314	CDD:290606
		I-set	438..513	CDD:254352
		Ig	454..510	CDD:143165
		I-set	537..626	CDD:254352
		Ig	555..618	CDD:299845
		I-set	636..713	CDD:254352
		Ig	652..712	CDD:143165
		SMC_N	<2190..2854	CDD:280601
		I-set	5300..5388	CDD:254352
		IGc2	5313..5378	CDD:197706
		IG	5412..5482	CDD:214652
		IGc2	5413..5481	CDD:197706
		I-set	5542..5627	CDD:254352
		Ig	5556..5621	CDD:143165
		Ig	5654..5721	CDD:143165
		I-set	5784..5874	CDD:254352
		IGc2	5797..5864	CDD:197706
		I-set	5887..5970	CDD:254352
		Ig	5902..5966	CDD:143165
		I-set	5997..6086	CDD:254352
		Ig	6026..6083	CDD:143165
		I-set	6097..6187	CDD:254352
		Ig	6114..6187	CDD:299845
		FN3	6216..6310	CDD:238020
		I-set	6321..6412	CDD:254352	17/95 (18%)
		Ig	6328..6412	CDD:299845	15/91 (16%)
		I-set	6442..6531	CDD:254352	23/99 (23%)
		Ig	6459..6528	CDD:143165	18/79 (23%)
		I-set	6541..6632	CDD:254352	24/90 (27%)
		IGc2	6555..6622	CDD:197706	22/66 (33%)
		I-set	6662..6754	CDD:254352	6/91 (7%)
		Ig	6679..6751	CDD:143165	5/71 (7%)
		I-set	6779..6868	CDD:254352	29/92 (32%)
		IGc2	6793..6858	CDD:197706	28/68 (41%)
		Ig	6938..7022	CDD:299845	3/10 (30%)
		I-set	6939..7028	CDD:254352	3/9 (33%)
		IG	7075..7140	CDD:214652
		Ig	7075..7140	CDD:143165
		IG	7167..7239	CDD:214652
		Ig	7173..7239	CDD:143165
		Ig	7392..7475	CDD:299845
		IG	7406..7475	CDD:214652
		FN3	7489..7588	CDD:238020
		S_TKc	7620..7876	CDD:214567
		STKc_MLCK	7626..7876	CDD:271005
DIP-theta	NP_723103.1	Ig	137..230	CDD:299845	20/92 (22%)
		IG_like	137..230	CDD:214653	20/92 (22%)
		IG_like	240..324	CDD:214653	26/117 (22%)
		IGc2	247..310	CDD:197706	20/63 (32%)
		Ig	327..419	CDD:299845	35/203 (17%)
		IG_like	343..420	CDD:214653	31/155 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910