DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Strn-Mlck and bdl

DIOPT Version :9

Sequence 1:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster
Sequence 2:NP_608822.1 Gene:bdl / 33635 FlyBaseID:FBgn0028482 Length:719 Species:Drosophila melanogaster


Alignment Length:673 Identity:136/673 - (20%)
Similarity:222/673 - (32%) Gaps:234/673 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  6290 YHFRVTPKNRYGWGPTVQ---TSSPLQVGGVECLPEFVKILPGQAKALLGSSFTLQCNMRGAPRP 6351
            ||.:|:..||   .|:|:   |:..|.|.|    ...::|.|.......|.:....|.|:.....
  Fly   123 YHCQVSFPN
R---SPSVRNNGTAYHLAVQG----GSLIRIPPVNQTIREGQTAFFHCVMKHPENS 180

  Fly  6352 QVTWFKDGIQLSSSSERVKIRQIGSTCALTIATVSELDSGRYTCEATNSKGRVSTF-ARLQVVSD 6415
            |.:|:|||:.|....:.|:...:|...:|:|......|.|.|.|:..||.|.:.|. |.|.:...
  Fly   181 QASWYKDGVLLQEVQDLVRRFYMGPDGSLSIDPTMMSDLGEYECKVRNSDGELQTAKAFLNIQYK 245

  Fly  6416 SRIYEADSRLKEIAHGRNVADVGDSLPIFTMRLRDRRVQVTYPVRLTCQI-VGYPVPEILWYKDD 6479
            :::..|...: .:.:|:                         |..|.|.. ...|:..:.|.||.
  Fly   246 AKVIYAPPEV-FLPYGQ-------------------------PAVLDCHFRANPPLKNLRWEKDG 284

  Fly  6480 ELIHTDRKHLISAEGQFF----TLEIAATTLDDSGTYTCLARNELGSVSCHCTLVVDKGIRAYIS 6540
            .|..:     .:..|.|:    :|..|....:.:|:|||...|:||:          .|....||
  Fly   285 LLFDS-----YNVPGVFYKMNGSLFFAKVDENHAGSYTCTPYNDLGT----------DGPSPVIS 334

  Fly  6541 ------PDFYVPLDPFYIFREGSEIRLSTKVEAYPSVG-----VTWHRNGMRLRPSRRLT---AT 6591
                  |.|.|.....||.:.|....|  ..||....|     :.|.|...:..|:.|.:   ..
  Fly   335 VIVLRPPIFSVTPKAIYIQKLGEAAEL--PCEAIDRDGNNRPSIIWGRKDGQPLPADRFSLSGGN 397

  Fly  6592 LDSNGYVELIIAEATVRDAGIYVCVASNVVGKVETICRVAVEEAENKAVAPQRSLEIPSIKTDDL 6656
            |...|.||        .|.|||.|.|:|....:.....:.:|.     :||:            .
  Fly   398 LTITGLVE--------GDRGIYECSATNEAATITAEAELMIEN-----IAPR------------A 437

  Fly  6657 PYSKEPLFVVKPRSSEAYEGDNVIIFCEVVGDPKPEVVWLRDFLNP--EY---YK--DAPHFR-- 6712
            ||:      :...|:|.         |..:.       |...:|.|  ||   |:  :||.:|  
  Fly   438 PYN------LTANSTET---------CITIR-------WQPGYLRPNLEYTVWYRLMEAPEWRTL 480

  Fly  6713 RIGD-------------GPEYRLEIPSAKLDFTGTYSVIASNCHGEAKAVISLQIFAKDILNKSR 6764
            |:.|             |.||.             :.|::.:.:|:.       :|:|..     
  Fly   481 RVLDKKVMEATVQHLQPGKEYE-------------FMVLSQDKYGDG-------MFSKQF----- 520

  Fly  6765 MDKVHTRHGNIETLPRFVR---------------------------NLRNLRCCDGDAISLECHV 6802
                     ..:|||..:|                           ||..:....|..:..|..|
  Fly   521 ---------RFQTLPSPIRADDFDAQQLQHDLGQVTAPAGGLGAPWNLTAISNQQGWLLHWEHPV 576

  Fly  6803 EA-------------DPEPFIIWEKDGHVMPSDRDYVMSF--DGTKATLSIPRVYPEDEGEYTCV 6852
            :.             :||.|:|    ||....|..|.:..  :.|...:.:..|..|.:      
  Fly   577 QGLEGLRLYAVRWWKEPEHFLI----GHAETFDNYYQLRHLKEDTLFKVQVLAVGTETQ------ 631

  Fly  6853 AKNSVGRSLSSACIIVDVPEEKE 6875
                  :|:.|..:::|||.:::
  Fly   632 ------QSVPSHELLIDVPSQRK 648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Strn-MlckNP_001261019.1 IG_like 51..127 CDD:214653
Ig <69..>112 CDD:299845
I-set 137..226 CDD:254352
I-set 235..314 CDD:254352
Ig_2 244..314 CDD:290606
I-set 438..513 CDD:254352
Ig 454..510 CDD:143165
I-set 537..626 CDD:254352
Ig 555..618 CDD:299845
I-set 636..713 CDD:254352
Ig 652..712 CDD:143165
SMC_N <2190..2854 CDD:280601
I-set 5300..5388 CDD:254352
IGc2 5313..5378 CDD:197706
IG 5412..5482 CDD:214652
IGc2 5413..5481 CDD:197706
I-set 5542..5627 CDD:254352
Ig 5556..5621 CDD:143165
Ig 5654..5721 CDD:143165
I-set 5784..5874 CDD:254352
IGc2 5797..5864 CDD:197706
I-set 5887..5970 CDD:254352
Ig 5902..5966 CDD:143165
I-set 5997..6086 CDD:254352
Ig 6026..6083 CDD:143165
I-set 6097..6187 CDD:254352
Ig 6114..6187 CDD:299845
FN3 6216..6310 CDD:238020 8/22 (36%)
I-set 6321..6412 CDD:254352 25/91 (27%)
Ig 6328..6412 CDD:299845 24/84 (29%)
I-set 6442..6531 CDD:254352 19/93 (20%)
Ig 6459..6528 CDD:143165 18/73 (25%)
I-set 6541..6632 CDD:254352 25/98 (26%)
IGc2 6555..6622 CDD:197706 20/74 (27%)
I-set 6662..6754 CDD:254352 19/113 (17%)
Ig 6679..6751 CDD:143165 17/93 (18%)
I-set 6779..6868 CDD:254352 20/130 (15%)
IGc2 6793..6858 CDD:197706 14/79 (18%)
Ig 6938..7022 CDD:299845
I-set 6939..7028 CDD:254352
IG 7075..7140 CDD:214652
Ig 7075..7140 CDD:143165
IG 7167..7239 CDD:214652
Ig 7173..7239 CDD:143165
Ig 7392..7475 CDD:299845
IG 7406..7475 CDD:214652
FN3 7489..7588 CDD:238020
S_TKc 7620..7876 CDD:214567
STKc_MLCK 7626..7876 CDD:271005
bdlNP_608822.1 IG_like 42..128 CDD:214653 2/4 (50%)
Ig 43..131 CDD:299845 3/7 (43%)
I-set 153..242 CDD:254352 25/88 (28%)
Ig 157..242 CDD:299845 24/84 (29%)
Ig_2 252..337 CDD:290606 23/125 (18%)
IG_like 260..327 CDD:214653 20/106 (19%)
I-set 341..428 CDD:254352 25/96 (26%)
IGc2 356..419 CDD:197706 20/72 (28%)
FN3 435..524 CDD:238020 24/156 (15%)
FN3 554..636 CDD:238020 17/97 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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