DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strn-Mlck and DIP-beta

DIOPT Version :9

Sequence 1:	NP_001261019.1	Gene:	Strn-Mlck / 36753	FlyBaseID:	FBgn0265045	Length:	8255	Species:	Drosophila melanogaster
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	100/417 - (23%)
Similarity:	159/417 - (38%)	Gaps:	92/417 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  6314 VGGVECLPEFV----KILPGQAKALLGSSFTLQCNMRGAPR---------PQVTWFKDGIQ---- 6361
            ||..|  |:||    .:...|.:   .::||...|..|..|         .:|.|.|...:
  Fly    93 VGAFE--PDFVIPLENVTIAQGR---DATFTCVVNNLGGHRVSGDGSSAPAKVAWIKADAKAILA 152

  Fly  6362 ----LSSSSERVKIRQIG-STCALTIATVSELDSGRYTCEATNSKGRVSTFARLQVVSDSRIYEA 6421
                :.::::|:.::... :|..|.|..|...|:|:|.|:......::.| |.|:||....|
  Fly   153 IHEHVITNNDRLSVQHNDYNTWTLNIRGVKMEDAGKYMCQVNTDPMKMQT-ATLEVVIPPDI--- 213

  Fly  6422 DSRLKEIAHGRNVADVGDSLPIFTMRLRDRRVQVTYPVRLTCQIVGYPVPEILWYKDD--ELIHT 6484
               :.|...|..:...|.|                  .:|.|:..|:|.|:|.|.::|  |:|..
  Fly   214 ---INEETSGDMMVPEGGS------------------AKLVCRARGHPKPKITWRREDGREIIAR 257

  Fly  6485 DRKH----LISAEGQFFTLEIAATTLDDSGTYTCLARNEL-GSVSCHCTLVVDKGIRAYISPDFY 6544
            :..|    ..|.||:..||  :..|..:.|.|.|:|.|.: .:||....|.|      :..|...
  Fly   258 NGSHQKTKAQSVEGEMLTL--SKITRSEMGAYMCIASNGVPPTVSKRMKLQV------HFHPLVQ 314

  Fly  6545 VPLD----PFYIFREGSEIRLSTKVEAYPSVGVTWHR-NG-MRLRPSRRLTATLDSNGY-VELI- 6601
            ||..    |..     :::.|...|||.|.....|.| || |.:...|......::|.| :|:|
  Fly   315 VPNQLVGAPVL-----TDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAIEMIL 374

  Fly  6602 -IAEATVRDAGIYVCVASNVVGKVETICRVAVEEAENKAVAPQRSLEIPSIKTDDL-PYSKEPLF 6664
             |......|.|.|.|::.|.:|..|...|:...|...|.:          ::.||| ..||..:.
  Fly   375 HIKRLQSSDFGGYKCISKNSIGDTEGTIRLYEMERPGKKI----------LRDDDLNEVSKNEVV 429

  Fly  6665 VVKPRSSEAYEGDNVIIFCEVVGDPKP 6691
            ....||.:.....|..::.:...|..|
  Fly   430 QKDTRSEDGSRNLNGRLYKDRAPDQHP 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strn-Mlck	NP_001261019.1	IG_like	51..127	CDD:214653
		Ig	<69..>112	CDD:299845
		I-set	137..226	CDD:254352
		I-set	235..314	CDD:254352
		Ig_2	244..314	CDD:290606
		I-set	438..513	CDD:254352
		Ig	454..510	CDD:143165
		I-set	537..626	CDD:254352
		Ig	555..618	CDD:299845
		I-set	636..713	CDD:254352
		Ig	652..712	CDD:143165
		SMC_N	<2190..2854	CDD:280601
		I-set	5300..5388	CDD:254352
		IGc2	5313..5378	CDD:197706
		IG	5412..5482	CDD:214652
		IGc2	5413..5481	CDD:197706
		I-set	5542..5627	CDD:254352
		Ig	5556..5621	CDD:143165
		Ig	5654..5721	CDD:143165
		I-set	5784..5874	CDD:254352
		IGc2	5797..5864	CDD:197706
		I-set	5887..5970	CDD:254352
		Ig	5902..5966	CDD:143165
		I-set	5997..6086	CDD:254352
		Ig	6026..6083	CDD:143165
		I-set	6097..6187	CDD:254352
		Ig	6114..6187	CDD:299845
		FN3	6216..6310	CDD:238020
		I-set	6321..6412	CDD:254352	24/112 (21%)
		Ig	6328..6412	CDD:299845	21/101 (21%)
		I-set	6442..6531	CDD:254352	25/95 (26%)
		Ig	6459..6528	CDD:143165	24/75 (32%)
		I-set	6541..6632	CDD:254352	28/99 (28%)
		IGc2	6555..6622	CDD:197706	21/71 (30%)
		I-set	6662..6754	CDD:254352	5/30 (17%)
		Ig	6679..6751	CDD:143165	2/13 (15%)
		I-set	6779..6868	CDD:254352
		IGc2	6793..6858	CDD:197706
		Ig	6938..7022	CDD:299845
		I-set	6939..7028	CDD:254352
		IG	7075..7140	CDD:214652
		Ig	7075..7140	CDD:143165
		IG	7167..7239	CDD:214652
		Ig	7173..7239	CDD:143165
		Ig	7392..7475	CDD:299845
		IG	7406..7475	CDD:214652
		FN3	7489..7588	CDD:238020
		S_TKc	7620..7876	CDD:214567
		STKc_MLCK	7626..7876	CDD:271005
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	25/114 (22%)
		ig	102..195	CDD:278476	18/95 (19%)
		IG_like	219..307	CDD:214653	28/107 (26%)
		Ig	221..307	CDD:299845	27/105 (26%)
		Ig	311..404	CDD:299845	27/97 (28%)
		IG_like	327..405	CDD:214653	24/77 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910