DRSC/TRiP Functional Genomics Resources

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Protein Alignment Strn-Mlck and Cd22

DIOPT Version :9

Sequence 1:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster
Sequence 2:NP_001100973.1 Gene:Cd22 / 308501 RGDID:1311610 Length:852 Species:Rattus norvegicus


Alignment Length:925 Identity:186/925 - (20%)
Similarity:284/925 - (30%) Gaps:354/925 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  6350 RPQVTWFKDGIQLSS---SSERVKIRQIGSTCALTIATVSELDSGRYTCEATNSKGRVSTFARLQ 6411
            ||    |:..|||.|   .|:||.:     ||.|.........|.|::.:.:    .||......
  Rat   145 RP----FQPYIQLPSEIRESQRVSL-----TCGLNFTCFGYDISLRWSLDGS----EVSPVTSSI 196

  Fly  6412 VVSDSRIYEADSRL----KEIAHGRN----VADVGDSLPIFTMRLRDR---RVQVTY-------- 6457
            ..|...:| .:|:|    |...||::    |......|...|:||..:   ::|:|.        
  Rat   197 TSSVENVY-TESKLTFQPKWTDHGKSMMCQVWHFSQVLSERTVRLDVKYTPKLQITVNPTEVKEG 260

  Fly  6458 -PVRLTCQI----VGYPVPEILWYKDDELIHTDRKHLISAEGQFFTLEIAATTLDDSGTYTCLAR 6517
             .|.:|||:    ......::.|:||...:...:      |.:..||.  :.|.|..|.|.|.|.
  Rat   261 NSVTMTCQVNSSNPSLSTKKVSWFKDGSFLKEQQ------EQEELTLH--SVTKDMRGKYQCRAS 317

  Fly  6518 NELG-SVSCHCTLVV-----DKGIRAYISPDFYVPLDPFYIFREGSEIRLSTKVEAYP-SVGVTW 6575
            |.:| ..|....|.|     ...:..|.||           ..||..:.|.....|.| :...||
  Rat   318 NNIGQGQSKEVALTVLYPPEPSKVHIYPSP-----------AEEGQSVELICDSLASPRATNYTW 371

  Fly  6576 HRNGMRLRPSRRLTATLDSNGYVELIIAEATVRDAGIYVCVASNVVGKVETICRVAVEEAENKAV 6640
            :.||          ..:....:.:|.|:..::..||.|.|:|.|.:|     |....:|||.   
  Rat   372 YHNG----------EMVPGASHEKLQISNVSLWHAGKYSCLAENRLG-----CGKIEQEAEL--- 418

  Fly  6641 APQRSLEIPSIKTDDLPYSKEPLFVVKPRSSEAYEGDNVIIFCEVVGDPKPEVVWLRDFLNPEYY 6705
                          |:.|..:.:..|....:...|||:|.:.|. .....|||.         .|
  Rat   419 --------------DVHYVPKAVTTVIQSVTPIREGDSVTLDCR-YNSSNPEVT---------KY 459

  Fly  6706 KDAPHFRRIGDGPE-----YRLE--------IPSAKLDFTGTYSV-IASNCHGEAKAVISLQIFA 6756
            :.:|.    |.|.|     .|::        |..|..::..::|. ::.|.|...:||       
  Rat   460 EWSPQ----GSGSEVTPGVLRIQKATWDSPPIKCAACNYKCSWSFPVSLNVHYAPRAV------- 513

  Fly  6757 KDILNKSRMDKVHTRHGNIETLPRFVRNLRNLRCCDGDAISLECHVEAD--PEPFIIWEKDGHVM 6819
             .||..|...::|.                      |..:.|:|.....  .|....|:|:|:::
  Rat   514 -KILKVSPASEIHA----------------------GQHVLLQCDFSGSFPTEVRFFWKKNGNLV 555

  Fly  6820 PSDRDYVMSFDGTKATLSIPRVYPEDEGEYTCVAKNSVGRSLSSACIIVDVPEEKENMLSRQLAR 6884
            ...|           .|:...:.|||.|.|.|:.:||:|.:.|.|             .|.|:. 
  Rat   556 QEGR-----------YLNFSSISPEDSGNYNCMVRNSIGETSSQA-------------WSLQVL- 595

  Fly  6885 PSGLLSAHSTPRSTPRSTPARSFSPLRLSYRTSSIDLSGVAERRRSDARNAITAPKFLAIPYNRV 6949
                                  ::|.||....|..|                            .
  Rat   596 ----------------------YAPRRLRVSISPGD----------------------------S 610

  Fly  6950 VEEGDSVRFQCAISGHPT--PWATWDKDGLIVTPTPRIAVKEIDDLRI----IEIDEVTFDDAGL 7008
            |.||......|....||.  .:..:|.:.              .||..    :.::.:.....|.
  Rat   611 VMEGKKATLSCESDAHPPVFKYIWFDAND--------------QDLHFSGQKLRLEPLRVQHTGS 661

  Fly  7009 YRVTLENDFGRIEATARLDVIRSSRYSKS-PSVRSVRASSSRRNAHLYRRIMGPSTAIGGRMALA 7072
            ||....|:.|.               .|| ||..:|..|              |.| ||.|:||.
  Rat   662 YRCQGINELGT---------------GKSPPSTLTVYYS--------------PET-IGKRVALG 696

  Fly  7073 SGY---------RGSSVPSVRFYHNDVELEASERVHILLQDSMALLIVDNVTREDEGQYTCIISG 7128
            .|:         .|..:.. ::.||                           |..:|        
  Rat   697 LGFCLAICILAIWGMKIQK-KWKHN---------------------------RSQQG-------- 725

  Fly  7129 DHDPLITSTTVTFHDSNTEIRRRRAVITERLPEITKSLEGEVIDLCCSIECDEPYSYVWLRNGEI 7193
               |...|:..:|...|.:.||            |:..||.....|.::..|:..||..||    
  Rat   726 ---PQDNSSGQSFFVRNKKARR------------TRLTEGPQSQGCYNLAMDDTVSYAVLR---- 771

  Fly  7194 LPDSDEFNYIDHGNG 7208
            .|:||     .||.|
  Rat   772 FPESD-----THGAG 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Strn-MlckNP_001261019.1 IG_like 51..127 CDD:214653
Ig <69..>112 CDD:299845
I-set 137..226 CDD:254352
I-set 235..314 CDD:254352
Ig_2 244..314 CDD:290606
I-set 438..513 CDD:254352
Ig 454..510 CDD:143165
I-set 537..626 CDD:254352
Ig 555..618 CDD:299845
I-set 636..713 CDD:254352
Ig 652..712 CDD:143165
SMC_N <2190..2854 CDD:280601
I-set 5300..5388 CDD:254352
IGc2 5313..5378 CDD:197706
IG 5412..5482 CDD:214652
IGc2 5413..5481 CDD:197706
I-set 5542..5627 CDD:254352
Ig 5556..5621 CDD:143165
Ig 5654..5721 CDD:143165
I-set 5784..5874 CDD:254352
IGc2 5797..5864 CDD:197706
I-set 5887..5970 CDD:254352
Ig 5902..5966 CDD:143165
I-set 5997..6086 CDD:254352
Ig 6026..6083 CDD:143165
I-set 6097..6187 CDD:254352
Ig 6114..6187 CDD:299845
FN3 6216..6310 CDD:238020
I-set 6321..6412 CDD:254352 17/64 (27%)
Ig 6328..6412 CDD:299845 17/64 (27%)
I-set 6442..6531 CDD:254352 25/105 (24%)
Ig 6459..6528 CDD:143165 19/73 (26%)
I-set 6541..6632 CDD:254352 20/91 (22%)
IGc2 6555..6622 CDD:197706 17/67 (25%)
I-set 6662..6754 CDD:254352 22/105 (21%)
Ig 6679..6751 CDD:143165 18/85 (21%)
I-set 6779..6868 CDD:254352 20/90 (22%)
IGc2 6793..6858 CDD:197706 17/66 (26%)
Ig 6938..7022 CDD:299845 14/89 (16%)
I-set 6939..7028 CDD:254352 14/94 (15%)
IG 7075..7140 CDD:214652 7/73 (10%)
Ig 7075..7140 CDD:143165 7/73 (10%)
IG 7167..7239 CDD:214652 14/42 (33%)
Ig 7173..7239 CDD:143165 12/36 (33%)
Ig 7392..7475 CDD:299845
IG 7406..7475 CDD:214652
FN3 7489..7588 CDD:238020
S_TKc 7620..7876 CDD:214567
STKc_MLCK 7626..7876 CDD:271005
Cd22NP_001100973.1 Ig 24..143 CDD:416386
FR1 24..47 CDD:409353
Ig strand A 24..28 CDD:409353
Ig strand A' 31..35 CDD:409353
Ig strand B 37..48 CDD:409353
CDR1 48..56 CDD:409353
Ig strand C 56..63 CDD:409353
FR2 57..63 CDD:409353
CDR2 64..95 CDD:409353
Ig strand C1 65..68 CDD:409353
Ig strand C2 71..75 CDD:409353
Ig strand C' 79..82 CDD:409353
FR3 96..129 CDD:409353
Ig strand D 97..101 CDD:409353
Ig strand E 106..114 CDD:409353
Ig strand F 121..129 CDD:409353
CDR3 130..132 CDD:409353
FR4 133..143 CDD:409353
Ig strand G 133..143 CDD:409353
IgC1_CD22_d2 147..242 CDD:409532 27/104 (26%)
Ig strand B 163..167 CDD:409532 1/8 (13%)
Ig strand C 179..183 CDD:409532 2/3 (67%)
Ig strand E 207..211 CDD:409532 2/3 (67%)
Ig strand F 221..226 CDD:409532 0/4 (0%)
Ig strand G 235..238 CDD:409532 0/2 (0%)
Ig 246..334 CDD:416386 23/95 (24%)
Ig strand A 246..253 CDD:409353 2/6 (33%)
Ig strand B 260..270 CDD:409353 4/9 (44%)
Ig strand C 277..285 CDD:409353 1/7 (14%)
Ig strand C' 287..290 CDD:409353 0/2 (0%)
Ig strand E 296..303 CDD:409353 2/8 (25%)
Ig strand F 310..318 CDD:409353 4/7 (57%)
Ig strand G 321..334 CDD:409353 4/12 (33%)
IGc2 350..408 CDD:197706 17/67 (25%)
Ig strand B 354..358 CDD:409353 1/3 (33%)
Ig strand C 367..372 CDD:409353 1/4 (25%)
Ig strand F 398..403 CDD:409353 2/4 (50%)
Ig 424..>466 CDD:416386 11/55 (20%)
Ig strand A 424..431 CDD:409353 0/6 (0%)
Ig strand A' 435..439 CDD:409353 0/3 (0%)
Ig strand B 440..450 CDD:409353 4/10 (40%)
Ig strand C 457..463 CDD:409353 1/14 (7%)
IGc2 527..583 CDD:197706 17/66 (26%)
Ig strand B 530..534 CDD:409353 1/3 (33%)
Ig strand C 543..549 CDD:409353 1/5 (20%)
Ig strand F 573..578 CDD:409353 2/4 (50%)
IG 610..682 CDD:214652 18/100 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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