DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Strn-Mlck and Mylk

DIOPT Version :9

Sequence 1:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster
Sequence 2:NP_001099344.2 Gene:Mylk / 288057 RGDID:1310915 Length:1961 Species:Rattus norvegicus


Alignment Length:2229 Identity:575/2229 - (25%)
Similarity:894/2229 - (40%) Gaps:531/2229 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  5967 NKISHQVDFKGRQHYSLEKTHGFFHRDPNKPHFLLPLGNQTVCNGGTVAISAEFMETSTPIEVKW 6031
            :|.||.||  ..:..||..|..        |.|:||..|..|..|.|............| :|.|
  Rat    22 SKTSHSVD--PSRVSSLPLTEA--------PAFILPPRNLCVKEGATAKFEGRVRGHPEP-QVTW 75

  Fly  6032 LRD--------RRVVDGPNVKALADRGVYTLTIMNAGPEVEGTYTCRASNAFGRIESNVNVDV-- 6086
            .|:        |.::||      ..||.::|.|.....|.:|.|||.|||..|..:..|.:.|  
  Rat    76 HRNGQTITNGGRFLLDG------GVRGTFSLVIRGVREEDKGKYTCEASNGSGARQVTVELTVEG 134

  Fly  6087 -------------AVGAEKDERPPLFLSRPD---TEMKIAV---GDPFSLSFRIAGDPKPKLTFM 6132
                         |.|...:.||.::...|.   |::..||   |.....|.:|.|.|.|::|::
  Rat   135 DLMKKHGQPVLSKASGFPGETRPSIWGECPPKFATKLGRAVVKEGQMGRFSCKITGRPPPQVTWL 199

  Fly  6133 KGTKDITQSDRVSKEVSDDYTRFSVQQAQISDSGTYFVVARNNFGTDRIFVTVTV----NPRARS 6193
            ||...:..|.|||....:......:.:....|.|||..:..|..|...:...:::    |....|
  Rat   200 KGNVPLQPSARVSMSEKNGMQILEIHEVTQDDMGTYTCMVVNGSGKASMSAELSIPGLDNATRLS 264

  Fly  6194 ATPTQPRWGLPLDSYSDTSYFRDP------PGCISTEP--LVVDSGPTHI-SLSWGKPVSANSAP 6249
            .....|...:..:..:..|  :||      ..|.|.:.  .:..:..:|: ||...|......:|
  Rat   265 RGTKDPSPDIRKEVTNGIS--KDPETVAESKNCSSPQKSNFLAQATNSHLKSLQQPKLKPCEDSP 327

  Fly  6250 -----------------VMAYKVEAWV----VGHEGGAYWRELGLTPINSFDAFNLKPNVEYHFR 6293
                             :.|.||:..|    :|..|....|:....|                .:
  Rat   328 RKVLQSSVLQKTSSTIVLQASKVQPEVRAAGIGASGPGEERKSLTAP----------------RQ 376

  Fly  6294 VTPKNRY-GWGPTVQT-----SSPLQVGGVECLPEFVKILPGQAKALLGSSFTLQCNMRGAPRPQ 6352
            .||..|. |.|.:|..     :.|::.......|:| :..|...:...|.:....|.:.|.|:|:
  Rat   377 ATPPTRQCGLGGSVGNKFITGNIPIENQRESRFPKF-ESQPQSQEVTEGQTVKFTCEVSGIPKPE 440

  Fly  6353 VTWFKDGIQLSSSSERVKIRQIGSTCALTIATVSELDSGRYTCEATNSKGRVSTFARLQVVSDSR 6417
            |.||.:||.:......|:|.:.|::..|.:......|||||:|.|:|:.|:||....|:|...| 
  Rat   441 VGWFLEGIPVRRQEGIVEIYEDGTSHYLCLPRAGTRDSGRYSCTASNTLGQVSCSWTLRVDRPS- 504

  Fly  6418 IYEADSRLKEIAHGRNVADVGDSLPIFTMRLRDRRVQVTYPVRLTCQIVGYPVPEILWYKDDELI 6482
                               :..:.|.|:..|:|..|.......|.|.:.|.|.|::.|..:.:.|
  Rat   505 -------------------LTQTAPSFSSVLKDSVVIEGQDFVLRCSVRGTPAPQVTWLLNGQPI 550

  Fly  6483 HTDRKHLISAEGQFFTLEIAATTLDDSGTYTCLARNELGSVSCHCTLVVD----KGIRAY----- 6538
            ...|....:.|.:   |.|.....:|.|||||||.|.||.|||..|:.|.    :|.||:     
  Rat   551 QFARSICEAGEAE---LHIQDALPEDRGTYTCLAENALGQVSCSATVTVQEKKGEGERAHRLPPA 612

  Fly  6539 ----ISPDFYVPLDPFYIFREGSEIRLSTKVEAYPSVGVTWHRNGMRLRPSRRLTATLDSNGYVE 6599
                .:|.|...|....:. :||::.::.:|...|...|.|..:|..::.|...... ...|:..
  Rat   613 PSKLFAPIFLQGLSDLKVM-DGSQVTMTVQVSGNPPPEVIWLHDGNEIQESEDFHFE-QKGGWHS 675

  Fly  6600 LIIAEATVRDAGIYVCVASNVVGKVETICRVAVEEAENKAVAPQRSLEIPSIKTDDLPYSKEPLF 6664
            |.|.|....|.|.|.|.|.|..|:|.|...:.|:|..:                     ..:|.|
  Rat   676 LCIQEVFPEDTGTYTCEAWNSAGEVRTQAILTVQEPHD---------------------GTQPWF 719

  Fly  6665 VVKPRSSEAYEGDNVIIFCEVVGDPKPEVVWLRDFLNPEYYKDAPHFRRIGDGPEYRLEIPSAKL 6729
            :.||||..|..|.:|:|.|.:.|||.|.|.||||  .....:|..||..:.:...:.|.:.:.:.
  Rat   720 ISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRD--GKALSRDHGHFELLQNEDVFTLVLKNVQP 782

  Fly  6730 DFTGTYSVIASNCHGEAKAVISLQIFAKDILNK--SRMDKVHTRHGNIETLPRFVRNLRNLRCCD 6792
            ...|.|.::..|..||....:||      :|:|  ||:.....|.      |.....|     |.
  Rat   783 WHAGQYEILLKNRVGECSCQVSL------MLHKGPSRVPPPRGRE------PASCEGL-----CG 830

  Fly  6793 GDAISLECHVEADPEPFI--IWEKDGHVMPSDRDYVMSFDGTKATLS---IPRVYPEDEGEYTCV 6852
            |   .:..|.:||.:..:  .|...|...|.:.|    .:..:..|.   ..|::.|:......|
  Rat   831 G---GVGAHGDADRDGTLRPCWPARGQGWPEEED----GEDVRGLLKRRVETRLHTEEAIRQQEV 888

  Fly  6853 A----KNSVGRSLSSACI----IVDVPEEKENM---LSRQLARPS------------------GL 6888
            .    ::.:|:.:|:..:    :.|:|.|:.:.   |.||: :|.                  .:
  Rat   889 GQLDFRDLLGKKVSTKTVSEDDLKDIPAEQMDFRANLQRQV-KPKTVSEEERKVHSPQQVDFRSV 952

  Fly  6889 LSAHSTPRSTP---RSTPARSFSPLRLSYRTSSIDLSGVAERRRSDARNAITAPKFLAIPYNRVV 6950
            |:...||: ||   :..|.::.:|   .:|      |.:..:::|.|.|.....:.|.      |
  Rat   953 LAKKGTPK-TPVPEKVPPQKAATP---DFR------SVLGSKKKSPAENGGNTAEVLN------V 1001

  Fly  6951 EEGDSVRFQCAISGHPTPWATWDKDGL---IVTPTPRIAVKEIDDLRIIEIDEVTFDDAGLYR-- 7010
            :.|:|          |||.......|.   |....|...:|.:.:.:..|    |....|..:  
  Rat  1002 KAGES----------PTPAGNAQPVGALKPIGNAKPAETLKSVGNAKPAE----TLKPVGNAKPA 1052

  Fly  7011 VTLENDFGRIEATARLDVIRSSRYSKSP----SVRSVRASSSRRNAHLYRRIMGPSTAIGGRMAL 7071
            .||: ..|.::....|..|.:::.|.||    :.:.:....|..||.     ...:..:.|:   
  Rat  1053 ETLK-PVGNVKPAETLKPIANAQPSGSPKPIANAQPIETQKSVANAK-----SAETPKLAGK--- 1108

  Fly  7072 ASGYRGSSVPSVRFYHNDVELEASERVHILLQDSMALLIVDNVTREDEGQYTCIISGDHDPLITS 7136
                  ..:..||   |||.   .::.|:                                    
  Rat  1109 ------EELKEVR---NDVN---CKKAHV------------------------------------ 1125

  Fly  7137 TTVTFHDSNTEIRRRRAVITERLPEITKSLEGEVIDLCCSIECDEPYSYVWLRNGEILPDSDEFN 7201
             ..|.::...|.:....|..|:|.::..: |||.:.|.|.:..|.|.:..|..||:.| .:.:|.
  Rat  1126 -GATGNEKRPESQGSAPVFKEKLQDVHVA-EGEKLLLQCQVTSDPPATVTWTLNGKTL-KTTKFI 1187

  Fly  7202 YIDHGNGRLCLRINDAFDIDSGIYSCQVFTSDINDSTSDSTFDSHSICSLINSGCSDCSSSGELC 7266
            .:........:.|..|...|.|:|.|....|                     :|.::||     |
  Rat  1188 ILAQEGSLFSVSIEKALPEDRGLYKCVAKNS---------------------AGQAECS-----C 1226

  Fly  7267 VLERDLRGQDEECVQLLKTP-----------LPVVCASGDEALFYARVFPCDAEADWYLNGQLLA 7320
            .:..|..|..|.    .|.|           .||:....|                         
  Rat  1227 QVTVDDAGTSEN----TKAPEMKSRRPKSSLTPVLGTESD------------------------- 1262

  Fly  7321 QADDSLNMTLESYPENGIRLLRMRDVTASRSGEICLQVKHPQAEFRRIPTTRTYTSLLVLPAIRG 7385
                                                      |..::.|.::|.|...:.|.   
  Rat  1263 ------------------------------------------ATVKKKPASKTPTKAAMPPQ--- 1282

  Fly  7386 NSSSSSLAARSCILTRPEDCTALIGGHVRLSVRYEPFPGTKVI---WYKACHPIVESSNVTIRTT 7447
                        |:..|||.....|..|.|   :....||:.|   |.|....|.||.|:.:..:
  Rat  1283 ------------IIQFPEDQKVRAGEPVEL---FGKVTGTQPITCTWMKFRKQIQESENIRVENS 1332

  Fly  7448 SQQSTLYITDISADDSGKYTVEVMNDYGVEAAAASVAVEGPPEPPSGQPSVS-LGPDRVAVAWCG 7511
            ...|.|.|.....:..|.||:.|.|......|..::.|...|:||:|.|..| :....:.::|.|
  Rat  1333 ESGSKLTILAARQEHCGCYTLVVENKLSSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYG 1397

  Fly  7512 PPYDGGCMITGFIIEMQTIGDENCDEDSWQQVTRVVDSLAYTVKNLQPERQYRFRVRAENIHGRS 7576
            ..||||..:..:.:|:.     :.::..|.::. ...|.::.|::|.|:|:|:|||||.|::|.|
  Rat  1398 SSYDGGSAVQSYNVEIW-----DTEDKVWTELA-TCRSTSFNVQDLLPDREYKFRVRAVNVYGTS 1456

  Fly  7577 APGQASELVQITNTPQR-------STSSDASDRFGQATVSVQSGGDFKSRFEIIEELGKGRFGIV 7634
            .|.|.|||..:...|:.       |...:........||:|.:.......::|.|.||.|:||.|
  Rat  1457 EPSQESELTAVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTVNTEQKVSDVYDIEERLGSGKFGQV 1521

  Fly  7635 YKVQERGQPEQLLAAKVIKCIKSQDRQKVLEEISIMRALQHPKLLQLAASFESPREIVMVMEYIT 7699
            :::.|: :..::.|.|..|...:::::.:.:|||||..|.||||:|...:||....||||:|.::
  Rat  1522 FRLVEK-RTGKIWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVS 1585

  Fly  7700 GGELFERVVADDFTLTEMDCILFLRQVCDGVAYMHGQSVVHLDLKPENIMCHTRTSHQIKIIDFG 7764
            |||||||::.:||.|||.:||.::||:.:||.|:|.|.:||||||||||||..:|..:||:||||
  Rat  1586 GGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFG 1650

  Fly  7765 LAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQSDMWSVGVICYVLLSGLSPFMGDTDVETFSN 7829
            ||:||:....::||||||||:.||:|:|||||:.:||||:|||||:|:|||||||||.|.||.:|
  Rat  1651 LARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLAN 1715

  Fly  7830 ITRADYDYDDEAFDCVSQEAKDFISQLLVHRKEDRLTAQQCLASKWLSQRPDDSLSNNKICTDKL 7894
            :|.|.:|:||||||.:|::||||||.||....::||...|||...|| .:...::...|:..|::
  Rat  1716 VTSATWDFDDEAFDEISEDAKDFISNLLKKDMKNRLDCTQCLQHPWL-MKDTKNMEAKKLSKDRM 1779

  Fly  7895 KKFIIRRKWQKTGNAIRALGRMANLSVSRRNSAIAMGVLSSPRPSISGLGMLTTSAIGSGTSSQM 7959
            ||::.||||||||||:||:||::::::                  ||||.. ..|:.||.||...
  Rat  1780 KKYMARRKWQKTGNAVRAIGRLSSMAM------------------ISGLSG-RKSSTGSPTSPIN 1825

  Fly  7960 TSLHEEEDDFS--------GEMPPVEKRTVLKLRD---------KSQC----------------- 7990
            ....|.|:|.|        .|.|.|:......:||         :..|                 
  Rat  1826 AEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQ 1890

  Fly  7991 ----SERSDSGYSECSNCS 8005
                |......|.|..|||
  Rat  1891 SIRESRHFQIDYDEDGNCS 1909

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Strn-MlckNP_001261019.1 IG_like 51..127 CDD:214653
Ig <69..>112 CDD:299845
I-set 137..226 CDD:254352
I-set 235..314 CDD:254352
Ig_2 244..314 CDD:290606
I-set 438..513 CDD:254352
Ig 454..510 CDD:143165
I-set 537..626 CDD:254352
Ig 555..618 CDD:299845
I-set 636..713 CDD:254352
Ig 652..712 CDD:143165
SMC_N <2190..2854 CDD:280601
I-set 5300..5388 CDD:254352
IGc2 5313..5378 CDD:197706
IG 5412..5482 CDD:214652
IGc2 5413..5481 CDD:197706
I-set 5542..5627 CDD:254352
Ig 5556..5621 CDD:143165
Ig 5654..5721 CDD:143165
I-set 5784..5874 CDD:254352
IGc2 5797..5864 CDD:197706
I-set 5887..5970 CDD:254352 1/2 (50%)
Ig 5902..5966 CDD:143165
I-set 5997..6086 CDD:254352 29/96 (30%)
Ig 6026..6083 CDD:143165 20/64 (31%)
I-set 6097..6187 CDD:254352 23/95 (24%)
Ig 6114..6187 CDD:299845 18/72 (25%)
FN3 6216..6310 CDD:238020 23/129 (18%)
I-set 6321..6412 CDD:254352 29/90 (32%)
Ig 6328..6412 CDD:299845 27/83 (33%)
I-set 6442..6531 CDD:254352 31/88 (35%)
Ig 6459..6528 CDD:143165 25/68 (37%)
I-set 6541..6632 CDD:254352 24/90 (27%)
IGc2 6555..6622 CDD:197706 18/66 (27%)
I-set 6662..6754 CDD:254352 31/91 (34%)
Ig 6679..6751 CDD:143165 21/71 (30%)
I-set 6779..6868 CDD:254352 17/101 (17%)
IGc2 6793..6858 CDD:197706 12/73 (16%)
Ig 6938..7022 CDD:299845 17/88 (19%)
I-set 6939..7028 CDD:254352 18/93 (19%)
IG 7075..7140 CDD:214652 6/64 (9%)
Ig 7075..7140 CDD:143165 6/64 (9%)
IG 7167..7239 CDD:214652 19/71 (27%)
Ig 7173..7239 CDD:143165 16/65 (25%)
Ig 7392..7475 CDD:299845 24/85 (28%)
IG 7406..7475 CDD:214652 20/71 (28%)
FN3 7489..7588 CDD:238020 33/99 (33%)
S_TKc 7620..7876 CDD:214567 136/255 (53%)
STKc_MLCK 7626..7876 CDD:271005 134/249 (54%)
MylkNP_001099344.2 I-set 42..132 CDD:254352 29/96 (30%)
Ig 64..129 CDD:143165 20/71 (28%)
I-set 165..254 CDD:254352 22/88 (25%)
Ig 183..251 CDD:143165 18/67 (27%)
23ISL 255..408 CDD:293226 28/170 (16%)
I-set 410..500 CDD:254352 29/90 (32%)
Ig 427..497 CDD:143165 24/69 (35%)
I-set 510..596 CDD:254352 31/88 (35%)
IGc2 523..586 CDD:197706 20/65 (31%)
I-set 619..708 CDD:254352 24/90 (27%)
Ig 636..704 CDD:143165 19/68 (28%)
I-set 717..805 CDD:254352 29/89 (33%)
Ig 720..805 CDD:299845 27/86 (31%)
I-set 1141..1230 CDD:254352 26/116 (22%)
IGc2 1154..1220 CDD:197706 19/87 (22%)
Ig 1281..1378 CDD:299845 29/114 (25%)
I-set 1281..1370 CDD:254352 26/106 (25%)
FN3 1374..1465 CDD:238020 32/96 (33%)
STKc_MLCK1 1504..1762 CDD:271093 136/258 (53%)
Pkinase 1507..1762 CDD:278497 136/255 (53%)
I-set 1852..1942 CDD:254352 9/58 (16%)
IGc2 1865..1932 CDD:197706 7/45 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 301 1.000 Domainoid score I1367
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007119
OrthoInspector 1 1.000 - - oto98220
orthoMCL 1 0.900 - - OOG6_104679
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X3431
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.810

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