DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Strn-Mlck and Dscam4

DIOPT Version :9

Sequence 1:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster
Sequence 2:NP_001261571.1 Gene:Dscam4 / 2769008 FlyBaseID:FBgn0263219 Length:1935 Species:Drosophila melanogaster


Alignment Length:2458 Identity:476/2458 - (19%)
Similarity:788/2458 - (32%) Gaps:819/2458 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  5890 PIRDTYSLNENELVLDCRVRGQPRPEIQWIKGTEPI-----------EASEKFKPSDQADGYAKL 5943
            |.|..:|.|...|: :|...|.|.||::|    .||           ..|..|.|. .|:.|.. 
  Fly    39 PHRVEFSNNSGGLI-ECSGHGSPPPEVEW----TPIPPQQDMVFQLSNGSMMFYPF-TAEKYRH- 96

  Fly  5944 VIVNPTEKDSGIYWCVARNEGAENKISHQVDFKG--RQHYSLEKTHGFFHRDPNKPHFLLPLGNQ 6006
                  |..:.:|.|..||. ....:|.:|..:|  .|.|::: .|..:          :..||.
  Fly    97 ------EVHATVYRCKLRNL-VGTVLSREVHVRGVVNQKYAVQ-VHDEY----------VMTGNT 143

  Fly  6007 TVCNGGTVAISAEFMETSTPIEVKWLRDRRVVDGPNVKALADRGVYT------LTIMNAGP-EVE 6064
            .|......:..:||:     :...|::|..:...||...   .|.||      |.|.|||| :..
  Fly   144 AVLKCQVPSYMSEFV-----LVTAWVQDTGMHLYPNTDI---GGKYTVLSNGELYINNAGPNDAY 200

  Fly  6065 GTYTCRASNAF----------GRI---ESNVNVDVAVGAEKDERPPLFLSRPDTEMKIAVGDPFS 6116
            .:||||..|..          |||   |....|...:..||.....:.|:...|...||.|.|..
  Fly   201 KSYTCRTVNRLTGEVQISTYPGRIIVTEPKGMVQPRINVEKHSMRHVVLNGQTTLPCIAQGHPVP 265

  Fly  6117 LSFRIAGDPKPKLTFMKGTKDITQSDRVSKEVSDDYTRFSVQQAQISDSGTYFVVARNNFGTDRI 6181
             ::|...:...:|..::.::.||   .||..:      ..:.:|::.|||.|.....|..|.:.|
  Fly   266 -TYRWFKEENEQLLPLQLSERIT---IVSAGL------LKITKARLEDSGKYLCWVNNTAGEETI 320

  Fly  6182 FVTVTVNPRARSATPTQPRWGLPLDSYSDTSYFRDPPGCISTEPLVVDSGPTHISLSW---GKPV 6243
            .|::||.  |......||: ...:|...|..:     .||      |...|.| .::|   |||:
  Fly   321 QVSLTVT--APLTAHLQPQ-VQTVDVDKDAQF-----QCI------VSGHPVH-DVNWLHDGKPI 370

  Fly  6244 SANS-------APVMAYKVEAWVVGHEGGAY-------WRELGLTPINSFDAFNLKPNVEYHFRV 6294
            ..::       .|.:..|.   |...:.|.|       |.:                        
  Fly   371 LRDNRVEILTDPPRLIIKK---VQKEDPGMYQCFVSNEWEQ------------------------ 408

  Fly  6295 TPKNRYGWGPTVQTSSPLQVGGVECLPEFVKILPGQAKALLGSSFTLQCNMRGAPRPQVTWFKDG 6359
                       :|:::.||:|  :..||.:.....|. ...|.:.:|:|...|.|.||.||..||
  Fly   409 -----------IQSTAELQLG--DASPELLYWFSEQT-LQPGPTVSLKCVATGNPLPQFTWSLDG 459

  Fly  6360 IQLSSSSERVKIRQIGSTCAL--------TIATVSELDSGRYTCEATNSKGRVSTFARLQVVSDS 6416
            ..:..||..:    :|....:        .|:.|.|.|.|.|||.|.|:.|:||..|::.:..  
  Fly   460 FPIPDSSRFL----VGQYVTIHDDVISHVNISNVKEEDGGEYTCTAQNAIGKVSHSAKVNIYG-- 518

  Fly  6417 RIYEADSRLKEIAHGRNVADVGDSLPIFTMRLRDRRVQVTYPVRLTCQIVGYPVPEILWYKDDEL 6481
                    |..|.....:..:..|                 .:.:.|.:.|||:.:|.|.:|.:.
  Fly   519 --------LPYIREMPKITGISGS-----------------DLIVKCPVAGYPIDKIHWERDGQT 558

  Fly  6482 IHTDRKHLISAEGQFFTLEIAATTLDDSGTYTCLARNELGSVSCHCTLVVDKGIRAYISPDFYVP 6546
            :..:|:......|.....::  ..|:|:|||||:|:|:....|..     :..|:..:.|.. :|
  Fly   559 LPINRRQRAYNNGTLIIEQL--QRLEDAGTYTCMAQNKQKQTSRR-----NVEIQVLVPPKI-MP 615

  Fly  6547 LDPF-YIFREGSEIRLSTKV-EAYPSVGVTWHRNGMRL-RPSRRLTATLDSNGYVELIIAEATVR 6608
            :... .:.|||....:|.:: |....|...|.|||..| .....:...||... ..|:|...:..
  Fly   616 IQAMTNMLREGMRAAISCQILEGDLPVSFRWERNGKPLIGTGNEVFRRLDEYS-ASLVIEHISSD 679

  Fly  6609 DAGIYVCVASNVVGKVETICRVAVEEAENKAVAPQRSLEIPSIKTDDLPYSKEPLFVVKPRSSEA 6673
            .:|.|.|:||||.|                    .....:|      |..:..|.::::|:.|.|
  Fly   680 HSGNYTCIASNVAG--------------------TERFTVP------LTVNVPPKWILEPKDSSA 718

  Fly  6674 YEGDNVIIFCEVVGDPKPEVVWLRDFLNPEYYKDAPHFRRIGDGP-EYR--LEIPSAKLDFTGT- 6734
            ..|.:|::.|:..|.|.|.:.|.               :.||..| ||:  |..|:.:|...|| 
  Fly   719 QAGADVLLHCQSSGYPTPTITWK---------------KAIGPTPGEYKDFLYEPTVQLFPNGTI 768

  Fly  6735 -YSVIASNCHG----EAK----AVISLQIFAKDILNKSRMDKVHTRHGNIETLPRFVRNLRNLRC 6790
             :..|:....|    |||    :.:|..||.|                 :.....|....:.:..
  Fly   769 FFKKISKESQGHFLCEAKNNIGSGVSKVIFLK-----------------VNVPAHFQTKTKQISV 816

  Fly  6791 CDGDAISLECHVEADPEPFIIWEKDGHVMPSD---------RDYVMSFDGTKATLSIPRVYPEDE 6846
            ..|..:.::|:|:.|......|:........|         ||.|:. ||..:.|.|...|.:|.
  Fly   817 AKGKQVHVQCNVQGDNPIDFKWKIQATQQYLDESLDSRYTIRDQVLD-DGMVSELGISHTYRQDT 880

  Fly  6847 GEYTCVAKNSVGR-SLSSACIIVDVPEEKENM-LSRQLARPSGLLSAHSTPRSTPRSTPARSFSP 6909
            |.|.|.|.|:.|: .:|...|:.:|||:.:|: ::.|.:|...|          ..|.|....||
  Fly   881 GIYICQASNAFGQDEMSIQLIVQEVPEQPKNLRINSQQSRSLQL----------TWSQPFAGNSP 935

  Fly  6910 L---RLSYRTSS--------IDLSGV-------------AERRRSDARNAITAPKFLAIPYNRVV 6950
            :   .:.|:..|        :.::|.             |...|..|.|.:.|.:|..:.....:
  Fly   936 IEEYHIYYKQISDIWQNAEHLTIAGAQTVINIQQLRPAKAYHIRMSAENKLGASEFSEVVQVTTL 1000

  Fly  6951 EE---GDSVRFQCAISGHPTPWATWDK------DGLIVTPTPRIAVKEIDDLRIIEIDEVTFDDA 7006
            ||   |..:..:.........:.|||.      :|:::                           
  Fly  1001 EEVPSGPPLAVRAEPKSSTEIFVTWDAPERDHWNGILL--------------------------- 1038

  Fly  7007 GL---YRVTLENDFGRIEATARLDVIRSSRYSKSPSVRSVRASSSRRNAHLYRRIMGPSTAIGGR 7068
            |.   |:::|..:...:..|.....       |:..|||          |           .||.
  Fly  1039 GYYVGYQMSLTPEDKEVNPTQGFSF-------KTVEVRS----------H-----------FGGE 1075

  Fly  7069 MALASGYRGSSVPSVRFYHNDVELEASERVHILLQ-----------DSMALLIVDNVTREDEGQY 7122
            ..||:                  |....:.|:::|           ..:|:..:::|........
  Fly  1076 TVLAN------------------LNKFTQYHVIVQAYTSQGSGPPSKEIAVQTMEDVPSSPPESP 1122

  Fly  7123 TCIISGDHDPLITSTTVTFHDSNTEIRRRRAV------ITERLPEITKSLEGEVIDLCCSIECDE 7181
            .|.:.|.....||.:.......|.:|:..:..      :.|..||:.||....|     :||...
  Fly  1123 QCDVLGSTSIYITWSPPDIDGQNGKIKGYKVFYISVDELYETDPEVVKSTNQYV-----TIENLR 1182

  Fly  7182 PYS--YVWLRNGEILPDSDEFNYIDHGNGR-----LCLRINDAFDIDSGIYSCQVFTSDI----- 7234
            .|:  .||:           ..|...|:|.     .|....|.......|.:....:|.|     
  Fly  1183 KYTNYTVWV-----------LAYTKVGDGMKTKPFYCRTHEDVPSAPQAIKAIPASSSKIIISWL 1236

  Fly  7235 -----NDSTSDSTFDSHSICSLINSGCSDCSSS---GELCVLERDLRGQDEECVQLLKTPLPVVC 7291
                 |...:..||    ..|::..|..:.:..   |....:...:|.|:....|.         
  Fly  1237 PPDLPNGDITGYTF----YMSMLEGGREEGTHKRLLGPFVEMHETVRTQESATYQF--------- 1288

  Fly  7292 ASGDEALFYARVFPCDAEADWYLNGQLLAQADDSLNMTLESYPENGIRLLRMRDVTASRSGEICL 7356
                                |......:.:.:.:..:|:.  |.|.:   ..|.|:.|:      
  Fly  1289 --------------------WLTASTKMGEGEKTQVVTVP--PNNKV---PARIVSFSQ------ 1322

  Fly  7357 QVKHPQAEFRRIPTTRTYTSLLVLPAIRGNSSSSSLAARSCILTRPEDCTALIGGHVRLSVRYEP 7421
            ::..|..|                                               |:.|..|...
  Fly  1323 RIVTPWKE-----------------------------------------------HLELPCRKVG 1340

  Fly  7422 FPGTKVIWYKACHPIVESSNVTIRTTSQQSTLYITDISADDSGKYTVEVMNDYGVEAAAASVAVE 7486
            .|....||.:..|.:..|:..||   ::..|||:.:..|.|:|.||..|.|.:|.:....::.|:
  Fly  1341 APAPVTIWRQDGHNMETSARKTI---AKNGTLYMKECQASDAGNYTCSVENTWGKDEIVYNIVVK 1402

  Fly  7487 GPPEPPSGQPSVSLGPDRVAVAWCGPPYDGGCMITGFIIEMQTIGDENCDEDSWQQVTRVVDS-- 7549
            .|||.|: ...::...|.:.:.|....: ||..|.|::|..:.      |...|:::.  |||  
  Fly  1403 VPPEAPN-LTVINAYTDSLLLEWMDNSH-GGSPILGYVINYKR------DNGDWEELQ--VDSKT 1457

  Fly  7550 LAYTVKNLQPERQYRFRVRAENIHGRSAPGQASELVQITNTP-QRSTSSDASDRFGQATVSVQSG 7613
            .::.:.||....:|:..:.|.|..|...|..........|.| |...|...::.....|..:.|.
  Fly  1458 TSHLLTNLWCGTRYQLYITAYNKIGTGLPCDIVNSYTKGNPPVQPKHSQMITNNSTSVTCWLDSW 1522

  Fly  7614 GDFKSRFEIIEELGKGRFGIVYKVQERGQPEQLLAAKVIKCIKSQDRQKVLEEISIMRALQHPKL 7678
            ||             |..||:|                                           
  Fly  1523 GD-------------GGCGILY------------------------------------------- 1531

  Fly  7679 LQLAASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDGVAYMHGQSVVHLDL 7743
                          .::|....|.....||::....||.  |..:..:..|..|         .|
  Fly  1532 --------------FMIESRVYGRSSWAVVSNHIPPTER--IYTVSDLVPGTKY---------QL 1571

  Fly  7744 KPENIMCHTRTSHQIKIIDF------GLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQSDMW 7802
            |   :..|........|.:|      |:....|...||..|...|              |.::..
  Fly  1572 K---VTAHNNAGSTTAIYNFTTLSTQGVIYNNDHSTPVSHLSDLP--------------FYANFK 1619

  Fly  7803 SVGVICYVLLSGLSPFMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVHRKEDRLTA 7867
            .:..||:.||..|:                                   .|...|..||. :|.:
  Fly  1620 LLLPICFSLLMLLA-----------------------------------LIGAALFLRKR-KLAS 1648

  Fly  7868 QQCLASKWLSQRPDDSLSNNKICTDKLKKFIIRR-----------KWQKTGNAIRALGR------ 7915
            |..|||..:|:.|  ||:|.:...::.::::..|           ....:|:..:|.|.      
  Fly  1649 QARLASSSMSESP--SLANLQNKQNRDQQYLAVRCNPGTSAPRGSNSNDSGSFGKAEGNEYIEDI 1711

  Fly  7916 --MANLSVSRR---NSAIAMGVLSSPRPSISGLGMLTTSAIGSGTSSQMTSLHEEEDDFSGEMPP 7975
              .|...::::   .|:.:..|.|.|..|:.|      |.:......:  |.|.:|.:::     
  Fly  1712 CPYATFQLNKQTYSESSYSGNVYSGPYHSVRG------SFVYHDVKPE--SYHSKEPEYT----- 1763

  Fly  7976 VEKRTVLKLRDKSQCSERSDSGYSECSNCSGAQETLLLSLAKSKLEAIAKASTL--PTVVHDTEQ 8038
            ..:|.|.:|||....|:.||:..|..|.                   :.|..||  |...:||  
  Fly  1764 KVRRKVGRLRDPHSESQESDNPGSTDSE-------------------VRKILTLHIPITEYDT-- 1807

  Fly  8039 PVSLELPTKGEAIMRSDFTNTIKMRKKSLEDSAAREKPRSKPQVKPLLCESKLKVSQLKDRFQVS 8103
                         :.|:..|.:..|  :|..:..|                    :|...:.:.|
  Fly  1808 -------------LGSESDNDVSAR--ALNSAKYR--------------------AQRDTQDETS 1837

  Fly  8104 PAPASASASASAANKPPLAYGPFKIAKVASVGRISRTEEPGRSGRGAPSVSGK 8156
            .:..:...|.:..:|||.|                     .|.| |.|..|||
  Fly  1838 SSSETTPTSMTRKSKPPFA---------------------ARKG-GKPGTSGK 1868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Strn-MlckNP_001261019.1 IG_like 51..127 CDD:214653
Ig <69..>112 CDD:299845
I-set 137..226 CDD:254352
I-set 235..314 CDD:254352
Ig_2 244..314 CDD:290606
I-set 438..513 CDD:254352
Ig 454..510 CDD:143165
I-set 537..626 CDD:254352
Ig 555..618 CDD:299845
I-set 636..713 CDD:254352
Ig 652..712 CDD:143165
SMC_N <2190..2854 CDD:280601
I-set 5300..5388 CDD:254352
IGc2 5313..5378 CDD:197706
IG 5412..5482 CDD:214652
IGc2 5413..5481 CDD:197706
I-set 5542..5627 CDD:254352
Ig 5556..5621 CDD:143165
Ig 5654..5721 CDD:143165
I-set 5784..5874 CDD:254352
IGc2 5797..5864 CDD:197706
I-set 5887..5970 CDD:254352 23/90 (26%)
Ig 5902..5966 CDD:143165 19/74 (26%)
I-set 5997..6086 CDD:254352 28/108 (26%)
Ig 6026..6083 CDD:143165 22/76 (29%)
I-set 6097..6187 CDD:254352 21/89 (24%)
Ig 6114..6187 CDD:299845 16/72 (22%)
FN3 6216..6310 CDD:238020 16/110 (15%)
I-set 6321..6412 CDD:254352 31/98 (32%)
Ig 6328..6412 CDD:299845 29/91 (32%)
I-set 6442..6531 CDD:254352 19/88 (22%)
Ig 6459..6528 CDD:143165 19/68 (28%)
I-set 6541..6632 CDD:254352 25/93 (27%)
IGc2 6555..6622 CDD:197706 21/68 (31%)
I-set 6662..6754 CDD:254352 27/104 (26%)
Ig 6679..6751 CDD:143165 21/84 (25%)
I-set 6779..6868 CDD:254352 24/98 (24%)
IGc2 6793..6858 CDD:197706 20/73 (27%)
Ig 6938..7022 CDD:299845 12/95 (13%)
I-set 6939..7028 CDD:254352 12/100 (12%)
IG 7075..7140 CDD:214652 9/75 (12%)
Ig 7075..7140 CDD:143165 9/75 (12%)
IG 7167..7239 CDD:214652 15/88 (17%)
Ig 7173..7239 CDD:143165 14/82 (17%)
Ig 7392..7475 CDD:299845 20/82 (24%)
IG 7406..7475 CDD:214652 20/68 (29%)
FN3 7489..7588 CDD:238020 22/100 (22%)
S_TKc 7620..7876 CDD:214567 39/261 (15%)
STKc_MLCK 7626..7876 CDD:271005 39/255 (15%)
Dscam4NP_001261571.1 Ig 31..124 CDD:416386 25/98 (26%)
Ig strand A 32..35 CDD:409353
Ig strand A' 41..45 CDD:409353 1/3 (33%)
Ig strand B 48..57 CDD:409353 2/9 (22%)
Ig strand D 75..78 CDD:409353 0/2 (0%)
Ig strand E 83..88 CDD:409353 2/4 (50%)
Ig strand F 101..109 CDD:409353 2/7 (29%)
Ig strand G 112..124 CDD:409353 2/11 (18%)
Ig 235..326 CDD:416386 23/100 (23%)
Ig strand A 235..238 CDD:409353 0/2 (0%)
Ig strand A' 244..248 CDD:409353 0/3 (0%)
Ig strand B 251..258 CDD:409353 1/6 (17%)
Ig strand C 266..271 CDD:409353 1/4 (25%)
Ig strand C' 276..279 CDD:409353 1/2 (50%)
Ig strand D 285..289 CDD:409353 2/6 (33%)
Ig strand E 292..298 CDD:409353 0/11 (0%)
Ig strand F 305..313 CDD:409353 2/7 (29%)
Ig strand G 316..326 CDD:409353 3/9 (33%)
IgC2_3_Dscam 329..417 CDD:409549 21/138 (15%)
Ig strand B 347..351 CDD:409549 0/8 (0%)
Ig strand C 360..364 CDD:409549 0/3 (0%)
Ig strand E 383..387 CDD:409549 1/3 (33%)
Ig strand F 397..402 CDD:409549 1/4 (25%)
Ig strand G 410..413 CDD:409549 1/2 (50%)
IgI_4_Dscam 422..516 CDD:409548 31/98 (32%)
Ig strand B 439..443 CDD:409548 1/3 (33%)
Ig strand C 452..456 CDD:409548 2/3 (67%)
Ig strand E 482..486 CDD:409548 0/3 (0%)
Ig strand F 496..501 CDD:409548 3/4 (75%)
Ig strand G 509..512 CDD:409548 1/2 (50%)
IgI_5_Dscam 520..607 CDD:409550 22/110 (20%)
Ig strand B 536..540 CDD:409550 0/3 (0%)
Ig strand C 549..553 CDD:409550 1/3 (33%)
Ig strand E 571..575 CDD:409550 1/3 (33%)
Ig strand F 586..591 CDD:409550 4/4 (100%)
Ig strand G 600..603 CDD:409550 0/7 (0%)
Ig 610..703 CDD:416386 27/120 (23%)
Ig strand A 611..613 CDD:409353 1/1 (100%)
Ig strand A' 620..624 CDD:409353 0/3 (0%)
Ig strand B 627..636 CDD:409353 1/8 (13%)
Ig strand C 641..648 CDD:409353 2/6 (33%)
Ig strand C' 650..652 CDD:409353 1/1 (100%)
Ig strand D 659..664 CDD:409353 0/4 (0%)
Ig strand E 668..675 CDD:409353 2/7 (29%)
Ig strand F 682..690 CDD:409353 4/7 (57%)
Ig strand G 693..702 CDD:409353 2/34 (6%)
IgI_7_Dscam 706..801 CDD:409546 30/126 (24%)
Ig strand B 724..728 CDD:409546 1/3 (33%)
Ig strand C 737..741 CDD:409546 0/3 (0%)
Ig strand E 766..770 CDD:409546 2/3 (67%)
Ig strand F 780..785 CDD:409546 0/4 (0%)
Ig strand G 794..797 CDD:409546 1/2 (50%)
Ig 818..904 CDD:416386 23/86 (27%)
putative Ig strand B 820..827 CDD:409353 0/6 (0%)
putative Ig strand C 835..841 CDD:409353 1/5 (20%)
putative Ig strand C' 853..856 CDD:409353 0/2 (0%)
putative Ig strand D 862..866 CDD:409353 1/4 (25%)
putative Ig strand E 868..874 CDD:409353 2/5 (40%)
putative Ig strand F 881..889 CDD:409353 4/7 (57%)
putative Ig strand G 892..902 CDD:409353 2/9 (22%)
FN3 906..999 CDD:238020 19/102 (19%)
FN3 1006..1110 CDD:238020 22/176 (13%)
fn3 1117..1203 CDD:394996 20/101 (20%)
FN3 1215..1307 CDD:238020 13/124 (10%)
Ig <1334..1401 CDD:416386 20/69 (29%)
Ig strand C 1345..1349 CDD:409353 1/3 (33%)
Ig strand D 1363..1366 CDD:409353 1/5 (20%)
Ig strand E 1367..1372 CDD:409353 3/4 (75%)
Ig strand F 1380..1388 CDD:409353 4/7 (57%)
Ig strand G 1394..1401 CDD:409353 0/6 (0%)
FN3 1405..1494 CDD:238020 22/98 (22%)
FN3 1499..1580 CDD:238020 23/164 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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