DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Strn-Mlck and Nexn

DIOPT Version :9

Sequence 1:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster
Sequence 2:XP_006233541.1 Gene:Nexn / 246172 RGDID:708354 Length:670 Species:Rattus norvegicus


Alignment Length:835 Identity:166/835 - (19%)
Similarity:335/835 - (40%) Gaps:206/835 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  4590 IDEKSQKAEVSEIVSEKITDEKAQESQKEEVKDSEAKPKKAKVLEKKSIEEEKLEDKKEKQTESA 4654
            :::.|||||:....|:.:......:..|.:|||.....::|:            |::.::::.  
  Rat     1 MNDVSQKAEILLSSSKPVPKSYVPKLGKGDVKDKFEAMQRAR------------EERNQRRSR-- 51

  Fly  4655 IDEKSQKAEVSEIVSEKITDEKAQESQMEEVKDSEAKPKKAKVLEKKSIEEAKLEDKKETQTDSA 4719
             |||.::.|  :.:.|:..:.:.||.:.....|.|.:|.|.                        
  Rat    52 -DEKQRRKE--QYIREREWNRRKQEIKDMLASDEEEEPSKV------------------------ 89

  Fly  4720 IDEKSQKAEVSEIVSEKITDEKAQESQKEEVKDSEAKPKK---AKVLEKKSIEE------EKLED 4775
              ||:...:::..|..|. ||..:..|:|:.|.:|.:.|:   ..:|||:.::.      |::||
  Rat    90 --EKAYVPKLTGTVKGKF-DEMEKHRQEEQRKRTEEERKRRIEQDLLEKRKMQRELAKRAEQIED 151

  Fly  4776 KKEKQTESAIDEKSQKAEVSEIVSEKITDEKAQESQKKEVKGSEAKPKKAKVLEKKSIEEEKLED 4840
            .....||||    |::.:.|.:::..........:.:|:.:..:.:.:..:|    |.||||...
  Rat   152 INNTGTESA----SEEGDDSLLITVVPAKSYRAAANRKDPEDLDREHRNGRV----SQEEEKTRH 208

  Fly  4841 KKEKQTESAIDEKSQKAEVSEIVSEKITDEKAQESQKKEVKDSEAKPKKAKVLEKKSIEEEKLEN 4905
            ::|.:   |:.|    |:...:|.:..|:.|         |:|....|.....|:  :|.::.||
  Rat   209 EEECR---ALKE----AKCLSLVMDDETEAK---------KESRFPGKLKSTFEE--LERQRQEN 255

  Fly  4906 KKEKQTESAIDEKSQKAEVSEIVSEKITDEKAQESQKKEVKDSEAKPKKAKVLEKKSIEEEKLED 4970
            :|::..|.|.....::....|.....:.:|: .|||..|....|.:|.|.: |..:.||.::.|:
  Rat   256 RKKQAEEEARRRLEEERRAFEEARRNMVNEE-DESQDTETVFKEYRPGKLR-LSFEEIERQRREE 318

  Fly  4971 KKEKQTESAIDEKFQKAEVSETVSEKITDEKA--EESRKEEVKDSEAKPKKAKVLEKKSIEEEKL 5033
            :|.|..|.|              ..::.:||.  .|:|:..|.|.:: |:..|.:.::|:...||
  Rat   319 EKRKAEEEA--------------RRRMEEEKKAFAEARRSMVLDDDS-PEIYKAVSQESLTPGKL 368

  Fly  5034 E--------DKKEKQTESAIDEKSQKAEVSETVSEKITDEKAQESQKKE-----------VKDSE 5079
            |        .|.|::.....:|:.||.|:.:...|::..|..:|.::.|           :|...
  Rat   369 EINFEQLLRQKMEEERRRTEEERRQKLEMEKQEFEQLRQEMGKEEEENESFGLSREYEELIKLKR 433

  Fly  5080 AKPKKAKILEKKSIEIEKLDEKKEKQTETKVATD-TKSQTVEVSEIVLEKISEEKAEESQKVELK 5143
            :...:||.|:.|   .||:.:..||:.:.|:..: .|.:.:::      :|.|.:||...:.:..
  Rat   434 SGSIQAKNLKSK---FEKIGQLSEKEVQKKIEEERAKRRAIDL------EIKEREAENFHEDDDV 489

  Fly  5144 DSEAKSKKAKVLEKKSTLKEKLDENDKKQKEDGATNKSQKAEAADVVPEKISEEKVAEIK-TPEP 5207
            |.:...|.......|..:|.:.::..|.::|:     .|:         :|.|:|:..:: ..:.
  Rat   490 DVKPAKKSESPFTHKVNMKARFEQMAKARQEE-----EQR---------RIEEQKLLRMQFEQKE 540

  Fly  5208 MDSKAKSKPDGLPADEKSHGAKVSESVPVKNEAEKTDQLSAKKPTVLDEDLVVPKRKPYLAEQTA 5272
            :|:..:.|.:.   ||:..|:.|:.|..                                     
  Rat   541 IDAALQKKRED---DEEEEGSIVNGSTT------------------------------------- 565

  Fly  5273 DSISLQTYKSMDSEYKDRKESRSAK---RKPTVDIQLTNRNTASGSDLKLTCGLSGH-EMNVQWF 5333
                           :|.:::||..   :||     |.|.:......::.|..::|. :..|.|:
  Rat   566 ---------------EDEEQTRSGAPWFKKP-----LRNTSVVDSEPVRFTVKVTGEPKPEVTWW 610

  Fly  5334 KDNCPIENGAKYRRTLNDGLSCLEIKSAELGDSGIYRCIASNQNGEVETSCLVTI 5388
            .:...:::|..|:........||.:......|.|.|.|.|.|..|...::|::||
  Rat   611 FEGELLQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNSKGSAASTCILTI 665

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Strn-MlckNP_001261019.1 IG_like 51..127 CDD:214653
Ig <69..>112 CDD:299845
I-set 137..226 CDD:254352
I-set 235..314 CDD:254352
Ig_2 244..314 CDD:290606
I-set 438..513 CDD:254352
Ig 454..510 CDD:143165
I-set 537..626 CDD:254352
Ig 555..618 CDD:299845
I-set 636..713 CDD:254352
Ig 652..712 CDD:143165
SMC_N <2190..2854 CDD:280601
I-set 5300..5388 CDD:254352 19/88 (22%)
IGc2 5313..5378 CDD:197706 14/65 (22%)
IG 5412..5482 CDD:214652
IGc2 5413..5481 CDD:197706
I-set 5542..5627 CDD:254352
Ig 5556..5621 CDD:143165
Ig 5654..5721 CDD:143165
I-set 5784..5874 CDD:254352
IGc2 5797..5864 CDD:197706
I-set 5887..5970 CDD:254352
Ig 5902..5966 CDD:143165
I-set 5997..6086 CDD:254352
Ig 6026..6083 CDD:143165
I-set 6097..6187 CDD:254352
Ig 6114..6187 CDD:299845
FN3 6216..6310 CDD:238020
I-set 6321..6412 CDD:254352
Ig 6328..6412 CDD:299845
I-set 6442..6531 CDD:254352
Ig 6459..6528 CDD:143165
I-set 6541..6632 CDD:254352
IGc2 6555..6622 CDD:197706
I-set 6662..6754 CDD:254352
Ig 6679..6751 CDD:143165
I-set 6779..6868 CDD:254352
IGc2 6793..6858 CDD:197706
Ig 6938..7022 CDD:299845
I-set 6939..7028 CDD:254352
IG 7075..7140 CDD:214652
Ig 7075..7140 CDD:143165
IG 7167..7239 CDD:214652
Ig 7173..7239 CDD:143165
Ig 7392..7475 CDD:299845
IG 7406..7475 CDD:214652
FN3 7489..7588 CDD:238020
S_TKc 7620..7876 CDD:214567
STKc_MLCK 7626..7876 CDD:271005
NexnXP_006233541.1 PTZ00121 <25..549 CDD:173412 129/633 (20%)
I-set 576..665 CDD:400151 20/93 (22%)
Ig strand A 576..578 CDD:409353 0/1 (0%)
Ig strand A' 580..586 CDD:409353 4/10 (40%)
Ig strand B 593..600 CDD:409353 1/6 (17%)
Ig strand C 606..611 CDD:409353 2/4 (50%)
Ig strand C' 613..616 CDD:409353 0/2 (0%)
Ig strand D 621..625 CDD:409353 1/3 (33%)
Ig strand E 630..637 CDD:409353 2/6 (33%)
Ig strand F 644..652 CDD:409353 4/7 (57%)
Ig strand G 655..666 CDD:409353 4/11 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166340520
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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