DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Strn-Mlck and Mylk4

DIOPT Version :9

Sequence 1:	NP_001261019.1	Gene:	Strn-Mlck / 36753	FlyBaseID:	FBgn0265045	Length:	8255	Species:	Drosophila melanogaster
Sequence 2:	XP_006516731.1	Gene:	Mylk4 / 238564	MGIID:	3643758	Length:	656	Species:	Mus musculus

Alignment Length:	483	Identity:	173/483 - (35%)
Similarity:	259/483 - (53%)	Gaps:	53/483 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  7438 ESSNVTIRTTSQQSTLYITDISADDSGKYTVEVMNDYGVEA-----AAASVAV-------EGPPE 7490
            ||:|:..:..::.:......||:.|..:         ||||     ||||.||       ....|
Mouse   187 ESNNLRDKQDTEDNNGGENGISSKDDSR---------GVEAENRASAAASGAVLDKHSTESQHTE 242

  Fly  7491 PPSGQPS---------VSLGPDRVAVAWCGPPYDGGCMITGFIIEMQTIGD------ENC--DED 7538
            ..:|.||         .:..|..:..:..|..:...       .:.::.|.      |.|  .||
Mouse   243 DMNGDPSHERCISNIKTTSTPGILGNSASGSTFQNA-------EQTESTGSSKRRVAEECFLSED 300

  Fly  7539 SWQQVTRVVDSLAYTVKNLQPERQYRFRVRAENIHGRSAPGQASELVQITNTPQRSTSSDASDRF 7603
            :.:....||.      :..:|..:.....:|.::..|...|..:...|....|.....:.|:...
Mouse   301 NKKSRIDVVR------RGEEPTARTEETRQARSLGDRLQDGMTTSREQDLEVPLDDIPAPAAPFD 359

  Fly  7604 GQATVSVQSGGDFKSRFEIIEELGKGRFGIVYKVQERGQPEQLLAAKVIKCIKSQDRQKVLEEIS 7668
            .:..::..:..|........|.||.||||.|:|.:|:....: ||||:||...::|::.|..|||
Mouse   360 HRMVMAKHASVDNLYTVSKSEILGGGRFGQVHKCEEKATGLK-LAAKIIKTRGAKDKEDVKNEIS 423

  Fly  7669 IMRALQHPKLLQLAASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDGVAYM 7733
            :|..|.|..|:||..:|||..:|::||||:.|||||:|::.::..|||:|.|||::|:|:|:.||
Mouse   424 VMNQLDHVNLIQLYDAFESKHDIILVMEYVEGGELFDRIIDENCNLTELDTILFMKQICEGIRYM 488

  Fly  7734 HGQSVVHLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQ 7798
            |...::|||||||||:|..|.:.||||||||||:|...:..::|.||||||:.||:::|:.:.|.
Mouse   489 HQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFS 553

  Fly  7799 SDMWSVGVICYVLLSGLSPFMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVHRKED 7863
            :||||||||.|:||||||||:||.|.||.:||....:|.:||.|..:|:|||:|||:||:..|..
Mouse   554 TDMWSVGVITYMLLSGLSPFLGDNDAETLTNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSW 618

  Fly  7864 RLTAQQCLASKWLSQRPDDS-LSNNKIC 7890
            |::|.:.|...|||.....| ||..|.|
Mouse   619 RISASEALKHPWLSDHKLHSRLSAQKNC 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strn-Mlck	NP_001261019.1	IG_like	51..127	CDD:214653
		Ig	<69..>112	CDD:299845
		I-set	137..226	CDD:254352
		I-set	235..314	CDD:254352
		Ig_2	244..314	CDD:290606
		I-set	438..513	CDD:254352
		Ig	454..510	CDD:143165
		I-set	537..626	CDD:254352
		Ig	555..618	CDD:299845
		I-set	636..713	CDD:254352
		Ig	652..712	CDD:143165
		SMC_N	<2190..2854	CDD:280601
		I-set	5300..5388	CDD:254352
		IGc2	5313..5378	CDD:197706
		IG	5412..5482	CDD:214652
		IGc2	5413..5481	CDD:197706
		I-set	5542..5627	CDD:254352
		Ig	5556..5621	CDD:143165
		Ig	5654..5721	CDD:143165
		I-set	5784..5874	CDD:254352
		IGc2	5797..5864	CDD:197706
		I-set	5887..5970	CDD:254352
		Ig	5902..5966	CDD:143165
		I-set	5997..6086	CDD:254352
		Ig	6026..6083	CDD:143165
		I-set	6097..6187	CDD:254352
		Ig	6114..6187	CDD:299845
		FN3	6216..6310	CDD:238020
		I-set	6321..6412	CDD:254352
		Ig	6328..6412	CDD:299845
		I-set	6442..6531	CDD:254352
		Ig	6459..6528	CDD:143165
		I-set	6541..6632	CDD:254352
		IGc2	6555..6622	CDD:197706
		I-set	6662..6754	CDD:254352
		Ig	6679..6751	CDD:143165
		I-set	6779..6868	CDD:254352
		IGc2	6793..6858	CDD:197706
		Ig	6938..7022	CDD:299845
		I-set	6939..7028	CDD:254352
		IG	7075..7140	CDD:214652
		Ig	7075..7140	CDD:143165
		IG	7167..7239	CDD:214652
		Ig	7173..7239	CDD:143165
		Ig	7392..7475	CDD:299845	6/36 (17%)
		IG	7406..7475	CDD:214652	6/36 (17%)
		FN3	7489..7588	CDD:238020	18/115 (16%)
		S_TKc	7620..7876	CDD:214567	128/255 (50%)
		STKc_MLCK	7626..7876	CDD:271005	127/249 (51%)
Mylk4	XP_006516731.1	STKc_MLCK4	371..631	CDD:271095	129/260 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910