DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Strn-Mlck and Mylk2

DIOPT Version :9

Sequence 1:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster
Sequence 2:NP_001074513.2 Gene:Mylk2 / 228785 MGIID:2139434 Length:613 Species:Mus musculus


Alignment Length:530 Identity:188/530 - (35%)
Similarity:281/530 - (53%) Gaps:78/530 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly  7446 TTSQQSTLYITDISADDSGKYTVEVMNDYGVEAAAASVAVEGPPEPPSGQPSVSLGPDRVAVAWC 7510
            |.:.::::...|.:...||       |....||.|...|.|.......|.|:....|...|:..|
Mouse   119 TATAEASIQKLDPTQAPSG-------NQGSGEAKAGKKAAECREAGRRGSPAFLHSP
SCPAIISC 176

  Fly  7511 GPPYDGGCMITGFIIEMQTIGDENCDEDSWQQVTRVVDSLAYTVKNLQPERQYRFRVRA------ 7569
            ..               :|:..:...|.:         .|.:|..::.|:.|....|:|      
Mouse   177 SE---------------KTLAVKPLSETT---------DLVFTGVSVTPDPQDPGPVKAGGTNAL 217

  Fly  7570 ---ENIHGRSAPGQASELVQITNTPQR-STSSDASDR--FGQA---------------------- 7606
               :......|.|||.:.....:|||| ...:..|:|  .|||                      
Mouse   218 AEKKKEEAEKASGQAGQAKVQGDTPQRIGFQAVPSERVEVGQALCLTAREEDCFQILDDCPPPPA 282

  Fly  7607 -----TVSVQSGGDFKSRFEI--IEELGKGRFGIVYKVQERGQPEQLLAAKVIKCIKSQDRQKVL 7664
                 .|.::: |:..|.|.:  .|.||.|:||.|....||....: |||||||....:|::.||
Mouse   283 PFPHRIVELRT-GNVNSEFSMNSKEALGGGKFGAVCTCTERATGLK-LAAKVIKKQTPKDKEMVL 345

  Fly  7665 EEISIMRALQHPKLLQLAASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDG 7729
            .||.:|..|.|..|:||.|:.|:..||::.||||.|||||||:|.:|:.|||:|.::|:||:|||
Mouse   346 LEIEVMNQLNHRNLIQLYAAIETSHEIILFMEYIEGGELFERIVDEDYHLTEVDTMVFVRQICDG 410

  Fly  7730 VAYMHGQSVVHLDLKPENIMCHTRTSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEIISYEP 7794
            :.:||...|:|||||||||:|...|.|.:||||||||:|.:....::|.||||||:.||:::|:.
Mouse   411 ILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQ 475

  Fly  7795 IGFQSDMWSVGVICYVLLSGLSPFMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVH 7859
            |..::||||:|||.|:||||||||:||.|.||.:|:..|::.:|:|.|:.||.|||||:|.||..
Mouse   476 ISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDEAKDFVSNLLTK 540

  Fly  7860 RKEDRLTAQQCLASKWLSQRPDDSLSNNKICTDK--LKKFIIRRKWQKTGNAIRALGRMANLSVS 7922
            .:..|::|:||||..||:...:.:...|:....:  |||::::|:|:|...|:.|..|...:|.|
Mouse   541 DQSARMSAEQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSS 605

  Fly  7923 RRNSAIAMGV 7932
              .:.:|:||
Mouse   606 --GALMALGV 613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Strn-MlckNP_001261019.1 IG_like 51..127 CDD:214653
Ig <69..>112 CDD:299845
I-set 137..226 CDD:254352
I-set 235..314 CDD:254352
Ig_2 244..314 CDD:290606
I-set 438..513 CDD:254352
Ig 454..510 CDD:143165
I-set 537..626 CDD:254352
Ig 555..618 CDD:299845
I-set 636..713 CDD:254352
Ig 652..712 CDD:143165
SMC_N <2190..2854 CDD:280601
I-set 5300..5388 CDD:254352
IGc2 5313..5378 CDD:197706
IG 5412..5482 CDD:214652
IGc2 5413..5481 CDD:197706
I-set 5542..5627 CDD:254352
Ig 5556..5621 CDD:143165
Ig 5654..5721 CDD:143165
I-set 5784..5874 CDD:254352
IGc2 5797..5864 CDD:197706
I-set 5887..5970 CDD:254352
Ig 5902..5966 CDD:143165
I-set 5997..6086 CDD:254352
Ig 6026..6083 CDD:143165
I-set 6097..6187 CDD:254352
Ig 6114..6187 CDD:299845
FN3 6216..6310 CDD:238020
I-set 6321..6412 CDD:254352
Ig 6328..6412 CDD:299845
I-set 6442..6531 CDD:254352
Ig 6459..6528 CDD:143165
I-set 6541..6632 CDD:254352
IGc2 6555..6622 CDD:197706
I-set 6662..6754 CDD:254352
Ig 6679..6751 CDD:143165
I-set 6779..6868 CDD:254352
IGc2 6793..6858 CDD:197706
Ig 6938..7022 CDD:299845
I-set 6939..7028 CDD:254352
IG 7075..7140 CDD:214652
Ig 7075..7140 CDD:143165
IG 7167..7239 CDD:214652
Ig 7173..7239 CDD:143165
Ig 7392..7475 CDD:299845 5/28 (18%)
IG 7406..7475 CDD:214652 5/28 (18%)
FN3 7489..7588 CDD:238020 17/107 (16%)
S_TKc 7620..7876 CDD:214567 132/257 (51%)
STKc_MLCK 7626..7876 CDD:271005 130/249 (52%)
Mylk2NP_001074513.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..168 12/55 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..240 4/20 (20%)
STKc_MLCK2 298..557 CDD:271092 133/259 (51%)
S_TKc 308..557 CDD:214567 130/249 (52%)
Calmodulin-binding. /evidence=ECO:0000250 591..603 3/11 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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