DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Strn-Mlck and Mylk

DIOPT Version :9

Sequence 1:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster
Sequence 2:NP_647461.3 Gene:Mylk / 107589 MGIID:894806 Length:1950 Species:Mus musculus


Alignment Length:2240 Identity:558/2240 - (24%)
Similarity:880/2240 - (39%) Gaps:565/2240 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  5967 NKISHQVDFKGRQHYSLEKTHGFFHRDPNK---------PHFLLPLGNQTVCNGGTVAISAEFME 6022
            :|.||.|                   ||:|         |.|:||..|..|..|.|.........
Mouse    22 SKTSHSV-------------------DPSKVSSMPLTEAPAFILPPRNLCVKEGATAKFEGRVRG 67

  Fly  6023 TSTPIEVKWLRDRRVVDGPNVKALAD---RGVYTLTIMNAGPEVEGTYTCRASNAFGRIESNVNV 6084
            ...| :|.|.|..:.:.... :.|.|   ||.::|.|.....|.:|.|||.|||..|..:..|.:
Mouse    68 YPEP-QVTWHRKGQAITNGG-RFLLDCGVRGTFSLVIHTVREEDKGKYTCEASNGSGARQVTVEL 130

  Fly  6085 DV---------------AVGAEKDERPPLFLSRPD---TEMKIAV---GDPFSLSFRIAGDPKPK 6128
            .|               |.|...:.||.::...|.   |::..||   |.....|.:|.|.|.|:
Mouse   131 TVEGNSMKKRDQPVLSKASGFPGETRPSIWGECPPKFATKLGRAVVKEGQMGRFSCKITGRPPPQ 195

  Fly  6129 LTFMKGTKDITQSDRVSKEVSDDYTRFSVQQAQISDSGTYFVVARNNFGTDRIFVTVTV------ 6187
            :|::||...:..|.|||....:......::.....|.|.|..:..|..|...:...:::      
Mouse   196 VTWLKGNVPLQPSARVSMSEKNGMQILEIRGVTRDDLGVYTCMVVNGSGKASMSAELSIPGLDNA 260

  Fly  6188 -----------NPRARSAT-----------------PTQPRWGLPLDSYSDTSYFRDPPGCISTE 6224
                       :|..|...                 |:..|.|  ..:.:..|:.:.|.   ..:
Mouse   261 ARLAVRGTKAPSPDIRKEVTNGVSKDPETVAESKNCPSPQRSG--SSARATNSHLKSPQ---EPK 320

  Fly  6225 PLVVDSGPTHISLSWGKPVSANSAPVMAYKVEAWVVGHEGGAYWRELGLTPINSFDAFNLKPNVE 6289
            |.:.:..|..:..|.....|.::..:.|.||:.            |..:..|.||     .|..:
Mouse   321 PKLCEDAPRKVPQSSILQKSTSTITLQALKVQP------------EARVPAIGSF-----SPGED 368

  Fly  6290 YHFRVTPKNRYGWGPTVQTSSPLQVGG-------------------VECLPEFVKILPGQAKALL 6335
            ......|:.  ...||.|:|....||.                   .|..|:..::..||....:
Mouse   369 RKSLAAPQQ--ATLPTRQSSLGGSVGNKFVTGNIPRESQRESTFPRFESQPQSQEVTEGQTVKFI 431

  Fly  6336 GSSFTLQCNMRGAPRPQVTWFKDGIQLSSSSERVKIRQIGSTCALTIATVSELDSGRYTCEATNS 6400
                   |.:.|.|:|.|.||.:||.:.......::.:.|.:..|.:......|||||:|.|:||
Mouse   432 -------CEVSGIPKPDVGWFLEGIPVRRREGITEVYEDGVSHHLCLLRARTRDSGRYSCTASNS 489

  Fly  6401 KGRVSTFARLQVVSDSRIYEADSRLKEIAHGRNVADVGDSLPIFTMRLRDRRVQVTYPVRLTCQI 6465
            .|:||....|.|                    :..::..:.|.|:..|:|..|.......|.|.:
Mouse   490 LGQVSCSWSLLV--------------------DRPNLAQTAPSFSSVLKDSVVIEGQDFVLRCSV 534

  Fly  6466 VGYPVPEILWYKDDELIHTDRKHLISAEGQFFTLEIAATTLDDSGTYTCLARNELGSVSCHCTLV 6530
            .|.|.|.:.|..:.:.|..  .|.| .|.....|.|.....:|.|||||||.|.:|.|||..|:.
Mouse   535 QGTPAPRVTWLLNGQPIQF--AHSI-CEAGVAELHIQDALPEDRGTYTCLAENAMGQVSCSATVT 596

  Fly  6531 VD----KGIRAY-ISPDFYVPLDPFYI-------FREGSEIRLSTKVEAYPSVGVTWHRNGMRLR 6583
            |.    :|.|.: :||....|:.|.::       ..:||::.::.:|...|...|.|..:|..::
Mouse   597 VQEKKGEGEREHRLSPARSKPIAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHDGNEIQ 661

  Fly  6584 PSRRLTATLDSNGYVELIIAEATVRDAGIYVCVASNVVGKVETICRVAVEEAENKAVAPQRSLEI 6648
            .|...... ...|:..|.|.|....|.|.|.|.|.|..|:|.|...:.|:|..:           
Mouse   662 ESEDFHFE-QKGGWHSLCIQEVFPEDTGTYTCEAWNSAGEVRTRAVLTVQEPHD----------- 714

  Fly  6649 PSIKTDDLPYSKEPLFVVKPRSSEAYEGDNVIIFCEVVGDPKPEVVWLRDFLNPEYYKDAPHFRR 6713
                      ..:|.|:.||||..|..|.:|:|.|.:.|||.|.|.||||  .....||:.||..
Mouse   715 ----------GTQPWFISKPRSVTATLGQSVLISCAIAGDPFPTVHWLRD--GRALSKDSGHFEL 767

  Fly  6714 IGDGPEYRLEIPSAKLDFTGTYSVIASNCHGEAKAVISLQIFAKDILNKSRMDKVHTRHGNIETL 6778
            :.:...:.|.:.:.:....|.|.::..|..||....:||.:                 |.:....
Mouse   768 LQNEDVFTLVLKNVQPWHAGQYEILLKNRVGECSCQVSLML-----------------HNSPSRA 815

  Fly  6779 PRFVRNLRNLRC---CDGDAISLECHVEADPEPFI--IWEKDGHVMPSDRDYVMSFDGTKATLS- 6837
            |  .|......|   |.|..:.  .|.:.|....:  .|...|...|.:.|    .:..:..|. 
Mouse   816 P--PRGREPASCEGLCGGGGVG--AHGDGDRHGTLRPCWPARGQGWPEEED----GEDVRGLLKR 872

  Fly  6838 --IPRVYPEDEGEYTCVA----KNSVGRSLSSACI----IVDVPEEKENM---LSRQLARPS--- 6886
              ..|::.|:......|.    ::.:|:.:|:..:    :.|:|.|:.:.   |.||: :|.   
Mouse   873 RVETRLHTEEAIRQQEVGQLDFRDLLGKKVSTKTVSEDDLKDIPAEQMDFRANLQRQV-KPKTIS 936

  Fly  6887 ---------------GLLSAHSTPRS-TPRSTPARSFSPLRLSYRTSSIDLSGVAERRRSDARNA 6935
                           .:|:...||:: .|...|.::.:|   .:|      |.:..:::|.:.|.
Mouse   937 EEERKVHSPQQVDFRSVLAKKGTPKTPVPEKAPPKAATP---DFR------SVLGGKKKSPSENG 992

  Fly  6936 ITAPKFLAIPYNRVVEEGDSVRFQCAISGHPTPWATWDKDGLIVTPTPRIAVKEIDDLRIIEIDE 7000
            ..:.:.|.      |:.|:|          |||.......|         |:|.:.:.:..|..:
Mouse   993 GNSAEVLN------VKAGES----------PTPAGDAQAIG---------ALKPVGNAKPAETPK 1032

  Fly  7001 VTFDDAGLYRVTLENDFGRIEATARLDVIRSSRYSKS-PSVRSVRASSSRR---NAHLYRRIMGP 7061
                           ..|..:.|..|..:.:::.::: ..:.:.:.|.|.:   ||    :...|
Mouse  1033 ---------------PIGNAKPTETLKPVGNTKPAETLKPIANAQPSGSLKPVTNA----QPAEP 1078

  Fly  7062 STAIGGRMALASGYRGSSVPSVRFYHNDVELEASERVHILLQDSMALLIVDNVTREDEGQYTCII 7126
            ...:|...: |...:.:....|:...|||..:                         :||     
Mouse  1079 QKPVGNAKS-AETSKPAGKEEVKEVKNDVNCK-------------------------KGQ----- 1112

  Fly  7127 SGDHDPLITSTTVTFHDSNTEIRRRRAVITERLPEITKSLEGEVIDLCCSIECDEPYSYVWLRNG 7191
                      ...|.::...|.:....|..|:|.::..: |||.:.|.|.:..|.|.:..|..||
Mouse  1113 ----------VGATGNEKRPESQGSAPVFKEKLQDVHVA-EGEKLLLQCQVISDPPATVTWSLNG 1166

  Fly  7192 EILPDSDEFNYIDHGNGRLCLRINDAFDIDSGIYSCQVFTSDINDSTSDSTFDSHSICSLINSGC 7256
            :.| .:.:|..:.....|..:.|..|...|.|:|.|....|                     :|.
Mouse  1167 KTL-KTTKFIVLAQEGSRFSVSIEKALPEDRGLYKCVAKNS---------------------AGQ 1209

  Fly  7257 SDCSSSGELCVLERDLRGQDEECVQLLKTPLPVVCASGDEALFYARVFPCDAEADWYLNGQLLAQ 7321
            ::||                                             |....|          
Mouse  1210 AECS---------------------------------------------CQVTVD---------- 1219

  Fly  7322 ADDSLNMTLESYPENGIRLLRMRDVTASRSGEICLQVKHPQAEFRRIPTTRTYTSLLVLPAIRGN 7386
                                   |...|.:      .|.|:.:.||..::        ||.:.|.
Mouse  1220 -----------------------DAQTSEN------TKAPEMKSRRPKSS--------LPPVLGT 1247

  Fly  7387 SSSSSLAARSC------------ILTRPEDCTALIGGHVRLSVRYEPFPGTKVI---WYKACHPI 7436
            .|.:::..:..            |:..|||.....|..|.|   :....||:.|   |.|....|
Mouse  1248 ESDATVKKKPAPKTPTKAAMPPQIIQFPEDQKVRAGEPVEL---FGKVAGTQPITCKWMKFRKQI 1309

  Fly  7437 VESSNVTIRTTSQQSTLYITDISADDSGKYTVEVMNDYGVEAAAASVAVEGPPEPPSGQPSVS-L 7500
            .||.::.:......|.|.|.....:..|.||:.|.|..|...|..::.|...|:||:|.|..| :
Mouse  1310 QESEHIKVENGESGSKLTILAARQEHCGCYTLVVENKLGSRQAQVNLTVVDKPDPPAGTPCASDI 1374

  Fly  7501 GPDRVAVAWCGPPYDGGCMITGFIIEMQTIGDENCDEDSWQQVTRVVDSLAYTVKNLQPERQYRF 7565
            ....:.::|.|..||||..:..:.:|:.     :.::..|:::. ...|.::.|::|.|:|:|:|
Mouse  1375 RSSSLTLSWYGSSYDGGSAVQSYNVEIW-----DTEDKVWKELA-TCRSTSFNVQDLLPDREYKF 1433

  Fly  7566 RVRAENIHGRSAPGQASELVQITNTPQR-------STSSDASDRFGQATVSVQSGGDFKSRFEII 7623
            ||||.|::|.|.|.|.|||..:...|:.       |...:........||:|.:.......::|.
Mouse  1434 RVRAVNVYGTSEPSQESELTAVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTVNTEQKVSDVYDIE 1498

  Fly  7624 EELGKGRFGIVYKVQERGQPEQLLAAKVIKCIKSQDRQKVLEEISIMRALQHPKLLQLAASFESP 7688
            |.||.|:||.|:::.|: :..::.|.|..|...::::..:.:|||||..|.||||:|...:||..
Mouse  1499 ERLGSGKFGQVFRLVEK-KTGKIWAGKFFKAYSAKEKDNIRQEISIMNCLHHPKLVQCVDAFEEK 1562

  Fly  7689 REIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDGVAYMHGQSVVHLDLKPENIMCHTR 7753
            ..||||:|.::|||||||::.:||.|||.:||.::||:.:||.|:|.|.:||||||||||||..:
Mouse  1563 ANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNK 1627

  Fly  7754 TSHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQSDMWSVGVICYVLLSGLSPF 7818
            |..:||:||||||:||:....::||||||||:.||:|:|||||:.:||||:|||||:|:||||||
Mouse  1628 TGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPF 1692

  Fly  7819 MGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVHRKEDRLTAQQCLASKWLSQRPDDS 7883
            |||.|.||.:|:|.|.:|:||||||.:|.:||||||.||....::||...|||...|| .:...:
Mouse  1693 MGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWL-MKDTKN 1756

  Fly  7884 LSNNKICTDKLKKFIIRRKWQKTGNAIRALGRMANLSVSRRNSAIAMGVLSSPRPSISGLGMLTT 7948
            :...|:..|::||::.||||||||||:||:||::::::                  ||||.. ..
Mouse  1757 MEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAM------------------ISGLSG-RK 1802

  Fly  7949 SAIGSGTSSQMTSLHEEEDDFS--------GEMPPVEKRTVLKLRD---------KSQC------ 7990
            |:.||.||.......|.|||.|        .|.|.|:......:||         :..|      
Mouse  1803 SSTGSPTSPINAEKLESEDDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYP 1867

  Fly  7991 ---------------SERSDSGYSECSNCS 8005
                           |......|.|..|||
Mouse  1868 DPEVVWFKDDQSIRESRHFQIDYDEDGNCS 1897

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Strn-MlckNP_001261019.1 IG_like 51..127 CDD:214653
Ig <69..>112 CDD:299845
I-set 137..226 CDD:254352
I-set 235..314 CDD:254352
Ig_2 244..314 CDD:290606
I-set 438..513 CDD:254352
Ig 454..510 CDD:143165
I-set 537..626 CDD:254352
Ig 555..618 CDD:299845
I-set 636..713 CDD:254352
Ig 652..712 CDD:143165
SMC_N <2190..2854 CDD:280601
I-set 5300..5388 CDD:254352
IGc2 5313..5378 CDD:197706
IG 5412..5482 CDD:214652
IGc2 5413..5481 CDD:197706
I-set 5542..5627 CDD:254352
Ig 5556..5621 CDD:143165
Ig 5654..5721 CDD:143165
I-set 5784..5874 CDD:254352
IGc2 5797..5864 CDD:197706
I-set 5887..5970 CDD:254352 1/2 (50%)
Ig 5902..5966 CDD:143165
I-set 5997..6086 CDD:254352 28/91 (31%)
Ig 6026..6083 CDD:143165 19/59 (32%)
I-set 6097..6187 CDD:254352 22/95 (23%)
Ig 6114..6187 CDD:299845 17/72 (24%)
FN3 6216..6310 CDD:238020 17/93 (18%)
I-set 6321..6412 CDD:254352 27/90 (30%)
Ig 6328..6412 CDD:299845 26/83 (31%)
I-set 6442..6531 CDD:254352 31/88 (35%)
Ig 6459..6528 CDD:143165 25/68 (37%)
I-set 6541..6632 CDD:254352 24/97 (25%)
IGc2 6555..6622 CDD:197706 18/66 (27%)
I-set 6662..6754 CDD:254352 32/91 (35%)
Ig 6679..6751 CDD:143165 22/71 (31%)
I-set 6779..6868 CDD:254352 17/104 (16%)
IGc2 6793..6858 CDD:197706 11/73 (15%)
Ig 6938..7022 CDD:299845 12/83 (14%)
I-set 6939..7028 CDD:254352 14/88 (16%)
IG 7075..7140 CDD:214652 6/64 (9%)
Ig 7075..7140 CDD:143165 6/64 (9%)
IG 7167..7239 CDD:214652 20/71 (28%)
Ig 7173..7239 CDD:143165 17/65 (26%)
Ig 7392..7475 CDD:299845 23/97 (24%)
IG 7406..7475 CDD:214652 19/71 (27%)
FN3 7489..7588 CDD:238020 33/99 (33%)
S_TKc 7620..7876 CDD:214567 136/255 (53%)
STKc_MLCK 7626..7876 CDD:271005 134/249 (54%)
MylkNP_647461.3 I-set 42..132 CDD:254352 28/91 (31%)
Ig 42..131 CDD:299845 28/90 (31%)
I-set 165..254 CDD:254352 21/88 (24%)
Ig 183..251 CDD:143165 17/67 (25%)
23ISL 255..409 CDD:293226 26/177 (15%)
I-set 411..501 CDD:254352 28/96 (29%)
Ig 428..498 CDD:143165 23/76 (30%)
I-set 511..597 CDD:254352 31/88 (35%)
IGc2 524..587 CDD:197706 21/65 (32%)
I-set 620..709 CDD:254352 22/89 (25%)
Ig 637..706 CDD:143165 19/69 (28%)
I-set 718..806 CDD:254352 30/89 (34%)
Ig 721..806 CDD:299845 28/86 (33%)
I-set 1129..1218 CDD:254352 27/156 (17%)
IGc2 1142..1208 CDD:197706 20/87 (23%)
Ig 1269..1366 CDD:299845 28/99 (28%)
I-set 1269..1358 CDD:254352 25/91 (27%)
FN3 1362..1453 CDD:238020 32/96 (33%)
STKc_MLCK1 1492..1750 CDD:271093 136/258 (53%)
Pkinase 1495..1750 CDD:278497 136/255 (53%)
I-set 1840..1930 CDD:254352 9/58 (16%)
IGc2 1853..1920 CDD:197706 7/45 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 300 1.000 Domainoid score I1424
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0007119
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_104679
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4882
SonicParanoid 1 1.000 - - X3431
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.840

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