DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Strn-Mlck and si:ch211-286b5.9

DIOPT Version :9

Sequence 1:	NP_001261019.1	Gene:	Strn-Mlck / 36753	FlyBaseID:	FBgn0265045	Length:	8255	Species:	Drosophila melanogaster
Sequence 2:	XP_017211393.1	Gene:	si:ch211-286b5.9 / 100003869	ZFINID:	ZDB-GENE-121214-63	Length:	347	Species:	Danio rerio

Alignment Length:	344	Identity:	79/344 - (22%)
Similarity:	119/344 - (34%)	Gaps:	113/344 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  6239 WGKPVSANSAPVMAYKVEAWVVGHEGGAYWRELGLTPINSF--------DAFNLKPNVEYHFRVT 6295
            ||  |..:...:.|.|....   |..|:|....|||....|        ::.||..|..|..||.
Zfish    21 WG--VKYSKMAICALKSSTI---HLSGSYTHPYGLTVTKIFWTVNPKIGESINLLDNSNYTGRVE 80

  Fly  6296 --PKNRYGWGPTVQTSSPLQVG-GVECL----------------------------PEFVKILPG 6329
              .|:::.:   |:.|:..|.. |:.||                            ||  :::.|
Zfish    81 YFDKDKFFF---VKLSNVRQEDEGMYCLRIETKVEKERHLGYPGIELTVTELRVETPE--EVVEG 140

  Fly  6330 QAKALLGSSFTLQCNMRGAPRPQVTWFKDGIQLSSSSERVKIRQIGSTCALTIATVSELDSGRYT 6394
            .:..|:..|   .||:...   ..:|:|:|...|        :.:|.. .|.:.:||..|||.|:
Zfish   141 DSPVLICKS---SCNLGST---NFSWYKNGESFS--------KWVGEN-QLILQSVSREDSGNYS 190

  Fly  6395 CEATNSKGRVSTFARLQV------VSDSRIYEADSRLKEIAHGRNVADVGDSLPIFTMRLRDRRV 6453
            |...:.|...|....|.|      ||.|            ..|..|...|||
Zfish   191 CAVRDLKDLPSPALTLNVRYPPKSVSVS------------VSGSAVIVSGDS------------- 230

  Fly  6454 QVTYPVRLTCQIVGYPVPEI--LWYKDDELIHTDRKHLISAEGQFFTLEIAATTLDDSGTYTCLA 6516
                 |.|:|.....| |.:  .|:|:::         .||.|...:..|::...:.||.|.|.|
Zfish   231 -----VTLSCSSDSNP-PALNFSWFKENQ---------SSAIGSGQSFSISSFNTNHSGRYYCEA 280

  Fly  6517 RNELGSV-SCHCTLVVDKG 6534
            .|:.||: |...:|....|
Zfish   281 HNKYGSLRSASVSLTAKDG 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Strn-Mlck	NP_001261019.1	IG_like	51..127	CDD:214653
		Ig	<69..>112	CDD:299845
		I-set	137..226	CDD:254352
		I-set	235..314	CDD:254352
		Ig_2	244..314	CDD:290606
		I-set	438..513	CDD:254352
		Ig	454..510	CDD:143165
		I-set	537..626	CDD:254352
		Ig	555..618	CDD:299845
		I-set	636..713	CDD:254352
		Ig	652..712	CDD:143165
		SMC_N	<2190..2854	CDD:280601
		I-set	5300..5388	CDD:254352
		IGc2	5313..5378	CDD:197706
		IG	5412..5482	CDD:214652
		IGc2	5413..5481	CDD:197706
		I-set	5542..5627	CDD:254352
		Ig	5556..5621	CDD:143165
		Ig	5654..5721	CDD:143165
		I-set	5784..5874	CDD:254352
		IGc2	5797..5864	CDD:197706
		I-set	5887..5970	CDD:254352
		Ig	5902..5966	CDD:143165
		I-set	5997..6086	CDD:254352
		Ig	6026..6083	CDD:143165
		I-set	6097..6187	CDD:254352
		Ig	6114..6187	CDD:299845
		FN3	6216..6310	CDD:238020	20/80 (25%)
		I-set	6321..6412	CDD:254352	23/90 (26%)
		Ig	6328..6412	CDD:299845	21/83 (25%)
		I-set	6442..6531	CDD:254352	21/91 (23%)
		Ig	6459..6528	CDD:143165	20/71 (28%)
		I-set	6541..6632	CDD:254352
		IGc2	6555..6622	CDD:197706
		I-set	6662..6754	CDD:254352
		Ig	6679..6751	CDD:143165
		I-set	6779..6868	CDD:254352
		IGc2	6793..6858	CDD:197706
		Ig	6938..7022	CDD:299845
		I-set	6939..7028	CDD:254352
		IG	7075..7140	CDD:214652
		Ig	7075..7140	CDD:143165
		IG	7167..7239	CDD:214652
		Ig	7173..7239	CDD:143165
		Ig	7392..7475	CDD:299845
		IG	7406..7475	CDD:214652
		FN3	7489..7588	CDD:238020
		S_TKc	7620..7876	CDD:214567
		STKc_MLCK	7626..7876	CDD:271005
si:ch211-286b5.9	XP_017211393.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910