Protein Alignment Cyp4aa1 and ERG11

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_011871.1
• Gene: ERG11 / 856398
• SGDID: S000001049
• Length: 530
• Species: Saccharomyces cerevisiae
• Alignment Length: 536
• Identity: 113/536 - (21%)
• Similarity: 220/536 - (41%)
• Gaps: 76/536 - (14%)

  Fly    13 LELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPS----LPFLGNCMLVTDK--DLMRR 71
            |.|...:.|::|...||..       :..:|.|||...||.    :|::|:.::...|  :....
Yeast    25 LPLAQRISLIIIIPFIYNI-------VWQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEE 82

  Fly    72 CAGKAFDLYGSLVRIWVLLFPFFAV-LEPEDLQVILSSK--KHTNKVFFYRLMHNFLGDGLI-TS 132
            |..|..|::.     :|||.....| |.|:..:.:.::|  ..:.:..:..|.....|.|:| ..
Yeast    83 CQKKYGDIFS-----FVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDC 142

  Fly   133 SGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYEN-----LDAEAVGTEINIAKYVNNCVLD 192
            ..|:....::.::.|......:.::....:.....:.:     |:....|| |::........:.
Yeast   143 PNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGT-IDVMVTQPEMTIF 206

  Fly   193 ILNEAVLGVPIK-KRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQKKRL 256
            ..:.::||..:: |...|.|.:. |...:|  ..|..|..|.|.|:   |:.|..    :.:|.:
Yeast   207 TASRSLLGKEMRAKLDTDFAYLY-SDLDKG--FTPINFVFPNLPLE---HYRKRD----HAQKAI 261

  Fly   257 NDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEIS--ESNRDFTEEDIVNEACTFMLAGQDSVGA 319
            :.....:|:.||:    ||...:|. |:|.:::.|  :.....|:::|.|.....::.||.:..|
Yeast   262 SGTYMSLIKERRK----NNDIQDRD-LIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAA 321

  Fly   320 AVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARK 384
            ..|:.|..|.:.|:.|.....|...:.:...:..|...|.||..:...|||.||::..:..:.||
Yeast   322 TSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRK 386

  Fly   385 LGEEVRL--AKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSEN------------- 434
            :.:::.:  ..:.:|||.:|.:.|..||.....:|:..:|...|::.:::.:
Yeast   387 VMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNKDSASSYSVGEEVDYGFGA 451

  Fly   435 -----RHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASG 494
                 ..||  |||..|...|||..||..::..::|..:|:.:.....|||.....|...:....
Yeast   452 ISKGVSSPY--LPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPT 514

  Fly   495 G----LWVRLKERDHP 506
            |    :|    |:.:|
Yeast   515 GPAKIIW----EKRNP 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	92/452 (20%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	95/460 (21%)