Protein Alignment Cyp4aa1 and CYP4F2

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 151/519 - (29%)
• Similarity: 259/519 - (49%)
• Gaps: 57/519 - (10%)

  Fly    19 LILLVISLS---------IYTFYATLNTYLRSVLLSLRLTGPPSLP----FLGNCMLVTDKDLMR 70
            |:||::..|         .|.||....          ||...|..|    |.|:..:|...:...
Human    20 LLLLLVGASWLLAHVLAWTYAFYDNCR----------RLRCFPQPPRRNWFWGHQGMVNPTEEGM 74

  Fly    71 RCAGKAFDLYGSLVRIWV-LLFPFFAVLEPEDLQVIL--SSKKHTNKVFFYRLMHNFLGDGLITS 132
            |...:....|....::|: .:.|..::..|:.::.::  |:.......|||..:..:|||||:.|
Human    75 RVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLS 139

  Fly   133 SGSKWSNHRRLIQPAFHHNLLEKFIDTF---VDASQSLYENLDAEAVGTEINIAKYVNNCVLDIL 194
            :|.|||.|||::.||||.|:|:.::..|   |:...:.::.|.:|.... :::.::::...||.|
Human   140 AGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSAC-LDMFEHISLMTLDSL 203

  Fly   195 NEAVLGVPI----KKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQKKR 255
            .:.|.....    |......|::|.|      .::..|..:..|.:|.:|:.|..........:.
Human   204 QKCVFSFDSHCQEKPSEYIAAILELS------ALVSKRHHEILLHIDFLYYLTPDGQRFRRACRL 262

  Fly   256 LNDFTRKMIQRRRQ------IQNNNNGNSERKCL--LD-HMIEISESNRDFTEEDIVNEACTFML 311
            ::|||..:||.||:      :.:.....::.|.|  :| .::...|..:..::|||..||.|||.
Human   263 VHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMF 327

  Fly   312 AGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP---TMTDLHEMRYMEMCIKEALR 373
            .|.|:..:.:::.|:.|.::||.|:||..|:..:.:|  |.|   ...||..:.::.||:||:||
Human   328 EGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKD--REPKEIEWDDLAHLPFLTMCMKESLR 390

  Fly   374 LYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHP 437
            |:|.||:|:|.:.:::.|.. ..:|.|....|..:.||....::||||.:.|.||.|||.:.|.|
Human   391 LHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSP 455

  Fly   438 YAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLK 501
            .||:|||||||.|||..||:.|:|.:::..|..:::||  ..|.......:.|||.||||:|::
Human   456 LAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLP--DHTEPRRKPELVLRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	133/439 (30%)
CYP4F2	NP_001073.3	CYP4F	74..515	CDD:410772	136/451 (30%)