DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4aa1 and CYP86C1

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_173862.1	Gene:	CYP86C1 / 839069	AraportID:	AT1G24540	Length:	522	Species:	Arabidopsis thaliana

Alignment Length:	540	Identity:	140/540 - (25%)
Similarity:	233/540 - (43%)	Gaps:	77/540 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TNLELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNC-MLVTDK-DLMRRC- 72
            |:|.|..:.:.||   .::     |.:|||..|:|  ..||...|.||.. ||..:| ||...|
plant    13 THLRLSDVALALV---GLF-----LLSYLREKLVS--KGGPVMWPVLGIIPMLALNKHDLFTWCT 67

  Fly    73 -----AGKAFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSS--KKHTNKVFFYRLMHNFLGDGLI 130
                 :|..|...|    ||..........:|.:::.||.:  |.:....|:.....:.|.||:.
plant    68 RCVVRSGGTFHYRG----IWFGGAYGIMTADPANVEHILKTNFKNYPKGAFYRERFRDLLEDGIF 128

  Fly   131 TSSGSKWSNHRRLIQPAFHHN-LLEKFIDTFVDASQS----LYENLDAEAVGTEIN--IAKYV-- 186
            .:....|...||:.:...|.: .||....|..|....    |.|||.......::.  :.::.
plant   129 NADDELWKEERRVAKTEMHSSRFLEHTFTTMRDLVDQKLVPLMENLSTSKRVFDLQDLLLRFTFD 193

  Fly   187 NNCVLDI------LNEAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKM 245
            |.|:...      |...:..:|..|..:|.     :.:...:.::|....:|...| ||.:..|
plant   194 NICISAFGVYPGSLETGLPEIPFAKAFEDA-----TEYTLARFLIPPFVWKPMRFL-GIGYERK- 251

  Fly   246 ANDELNQKKRL-NDFTRKMI-QRRRQIQNNNNGNSERKCLLDHMIEISESNRDFT-----EEDIV 303
                ||...|: :.|..|.: :||.:::...|.|.....|...|....|...|.|     .:...
plant   252 ----LNNAVRIVHAFANKTVRERRNKMRKLGNLNDYADLLSRLMQREYEKEEDTTRGNYFSDKYF 312

  Fly   304 NEACT-FMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATI--------FEDSNRAPTMTDLH 359
            .|.|| |::||:|:...|:.:..:|:.::||.:.|.:.|:..|        .||...|   .|..
plant   313 REFCTSFIIAGRDTTSVALVWFFWLVQKHPEVEKRILREIREIKRKLTTQETEDQFEA---EDFR 374

  Fly   360 EMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHT-LPAGSNVFICPYATHRLAHIY-PDPEKF 422
            ||.|::..:.|:||||||||:..::..|:..|...| :..|:.:....|:..|:..|: .|.|:|
plant   375 EMVYLQAALTESLRLYPSVPMEMKQALEDDVLPDGTRVKKGARIHYSVYSMGRIESIWGKDWEEF 439

  Fly   423 QPERFSPEN---SENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAA 484
            :|||:..|.   ||::  :.::.|:.|||.|:|.:||..::|.:.:.:|..|.:..|.|: .|..
plant   440 KPERWIKEGRIVSEDQ--FKYVVFNGGPRLCVGKKFAYTQMKMVAAAILMRYSVKVVQGQ-EIVP 501

  Fly   485 TFRITLRASGGLWVRLKERD 504
            ....||....|:.|.|:.||
plant   502 KLTTTLYMKNGMNVMLQPRD 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	119/470 (25%)
CYP86C1	NP_173862.1	p450	90..520	CDD:299894	111/446 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1194
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920