DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_038935973.1	Gene:	Cyp4f37 / 691312	RGDID:	1585102	Length:	526	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	145/499 - (29%)
Similarity:	246/499 - (49%)	Gaps:	62/499 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RLTGPPSLP----FLGNCMLVTDKDLMRRCAGKAFDLYGSLVRIWV-LLFPFFAVLEPEDLQVIL 106
            ||...|..|    |||:..::...:...:...:....:..:..||: .:.|...:::|..:..:|
  Rat    47 RLRCFPQSPKRNWFLGHLGVIQSNEEGMQLVTEMGQTFRDVHLIWLGPVSPVLRLVDPAFVAPLL 111

  Fly   107 SS------KKHTNKVFFYRLMHNFLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTF---VD 162
            .:      |..|    |...:..:|||||..|||.|||.||||:.||||.::|:.::.||   |:
  Rat   112 QAPALVAPKDPT----FLHFLKPWLGDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKTFNQSVN 172

  Fly   163 ASQSLYENLDAEAVGTEINIAKYVNNCVLDILNEAVLGVPIKKRGQDVAMMEDSPFR------QG 221
            ...:.:::|..|. ...:.:.:.::...||.|.:.:.|..        :..::||..      :.
  Rat   173 IMHAKWKHLCLEG-SARLEMFENISLMTLDSLQKCLFGFD--------SNCQESPSEYISATLEL 228

  Fly   222 KIMMPARFTQPWLLLDGIYHWTKMANDELNQK--KRLNDFTRKMIQRRRQIQNN--------NNG 276
            ..:...|..:.:|.||.:|:.|  |:.:..:|  ..::.||..:|:.||::.::        :..
  Rat   229 SSLTRKRSYKLFLYLDFLYYRT--ADGQRFRKACDLVHSFTDAVIRERRRLLSSQGVDEFLESKT 291

  Fly   277 NSERKCLLDHMIEI-----SESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQD 336
            .|:.|.|  ..|::     .|..::.::|||..||.|||..|.|:..:|:::.|:.|..:||.|:
  Rat   292 KSKSKTL--DFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYNLASHPEYQE 354

  Fly   337 RCVLELATIFEDSNRAP---TMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAK-HTLP 397
            ||..|:..:..|  |.|   ...||.::.::.|||||:|||:|....:.|:..:::.|.. ..:|
  Rat   355 RCRQEVWELLRD--REPEEIEWDDLAQLPFLTMCIKESLRLHPPAVDLLRRCTQDIVLPDGRVIP 417

  Fly   398 AGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKT 462
            .|:...|..:..|....::||||.:.|.||.|||.:.|.|.:|:|||||||.|||..||:.|:|.
  Rat   418 KGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENRQKRSPLSFIPFSAGPRNCIGQTFAMNEVKV 482

  Fly   463 IVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVR--LKERD 504
            .|...|..::.||...:.....  .:.|||.||||:|  |..||
  Rat   483 AVGLTLLRFRFLPDDKEPRRKP--ELILRAEGGLWLRVELLSRD 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	130/463 (28%)
Cyp4f37	XP_038935973.1	CYP4F	74..517	CDD:410772	134/463 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348438
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750