Protein Alignment Cyp4aa1 and CYP4F12

DIOPT Version :9

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 147/542 - (27%)
• Similarity: 260/542 - (47%)
• Gaps: 102/542 - (18%)

  Fly    18 ILILLVISLSI--------YTFYATLNTYLRSVLLSLRLTGPPSLP----FLGNCMLVTDKDLMR 70
            :|:|||:...:        |.||....          ||...|..|    |.|:..|:|..:...
Human    20 LLLLLVVGSWLLARILAWTYAFYNNCR----------RLQCFPQPPKRNWFWGHLGLITPTEEGL 74

  Fly    71 RCAGKAFDLYGSLVRIWV-LLFPFFAVLEPEDLQVI------LSSKKHTNKVFFYRLMHNFLGDG 128
            :.:.:....|.....:|: .:.||..:..|:.::.|      ::.|.:    .|.|.:..:||:|
Human    75 KNSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDN----LFIRFLKPWLGEG 135

  Fly   129 LITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSL---YENLDAEAVGTEINIAKYVNNCV 190
            ::.|.|.|||.|||::.||||.|:|:.:|..|..::..:   :::|.:|. .:.:::.::::...
Human   136 ILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEG-SSRLDMFEHISLMT 199

  Fly   191 LDILNEAV--------------------LGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLL 235
            ||.|.:.:                    |...::||.|.:...
Human   200 LDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQH---------------------- 242

  Fly   236 LDGIYHWTKMAND--ELNQKKRL-NDFTRKMIQRRRQ------IQNNNNGNSERKCL--LD-HMI 288
            :|.:|:   :::|  ..::..|| :|||..:|:.||:      |.:.....::.|.|  :| .::
Human   243 MDFLYY---LSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLL 304

  Fly   289 EISESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP 353
            ...|..:..::|||..||.|||..|.|:..:.:::.|:.|.::||.|:||..|:..:.:|  |.|
Human   305 SKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKD--RDP 367

  Fly   354 ---TMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAH 414
               ...||.::.::.||:||:|||:|..|.|:|...:::.|.. ..:|.|....|.....|....
Human   368 KEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPT 432

  Fly   415 IYPDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGK 479
            ::||||.:.|.||.||||:.|.|.||:|||||||.|||..||:.|:|.:::.:|..::.||  ..
Human   433 VWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLP--DH 495

  Fly   480 TTIAATFRITLRASGGLWVRLK 501
            |.......:.:||.||||:|::
Human   496 TEPRRKLELIMRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	128/474 (27%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	131/487 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154697
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750