DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4aa1 and zgc:123299

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_021324190.1	Gene:	zgc:123299 / 641477	ZFINID:	ZDB-GENE-051120-33	Length:	501	Species:	Danio rerio

Alignment Length:	526	Identity:	150/526 - (28%)
Similarity:	238/526 - (45%)	Gaps:	78/526 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ILLVISLSIYTFYATLNTYLRSVLLSL-RLTGPPSLPF-LGNCMLVTDK---------DLMRRCA 73
            |:|.:..:::|.:.....|:..:.... .:.|||...| ||:...:|..         ||..:.|
Zfish     9 IILYLLAAVFTAFFAYCLYVHHIHQKYDHIPGPPRDNFLLGHSPSLTKALYSDDSLIYDLFLQWA 73

  Fly    74 GKAFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHN-----FLGDGLITS- 132
            .|    ||.:.||..|.:....|..||..:.|:.|.|:|...|.||.:.|     |||.||||:
Zfish    74 EK----YGPVYRINTLHYVTIVVYCPEATKTIMMSPKYTKDPFVYRRVFNLFGKRFLGYGLITAV 134

  Fly   133 SGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVGTEINIAKYVNNCV-LDILNE 196
            ....|...||::.|||..:.|...|.||.:.|:.|.:.|:..|......:...:.||| ||::.:
Zfish   135 DHDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEEIANNKTPAVMHDLVNCVTLDVICK 199

  Fly   197 AVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFT------------QPWLLLDGIYHWTKMANDE 249
            ...||.:     :....:||||:....:.....|            :.|.|:..:...|::
Zfish   200 VAFGVDL-----NFLTQKDSPFQNAVELCLKGMTFDVRDPLFRIIPKNWKLIQQVREATEL---- 255

  Fly   250 LNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEISE-----SNRDFTEEDIVNEACTF 309
                  |.....|.||.|:...  .||....|.:|..:::.:|     |..||  |.:::...||
Zfish   256 ------LRKTGEKWIQNRKTAV--KNGEDVPKDILTQILKSAEEQNVTSTEDF--EQMLDNFVTF 310

  Fly   310 MLAGQDSVGAAVAFTLFLLTQNPECQDRCVLE----LATIFEDSNRAPTMTDLHEMRYMEMCIKE 370
            .:|||::....::|.:..|.:|||...|...|    |.|..|.||.     ||.::.|:...:||
Zfish   311 FMAGQETTANQLSFAIMELGRNPEIYKRAKAEVDEVLGTKREISNE-----DLGKLTYLSQVLKE 370

  Fly   371 ALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENR 435
            .|||||:.|...|.|.|::.:....:|.|.:|....:.:.||...:.||.||.|:||. ||:...
Zfish   371 TLRLYPTAPGTNRWLHEDMIINGIKIPGGCSVMFNSFVSQRLEKFFKDPLKFDPKRFD-ENAPKP 434

  Fly   436 HPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRI----TLRASGGL 496
            : |.:.||:.|||.|||..|:.||.|.::::||:.::...|.|:     :|.|    |||...|:
Zfish   435 Y-YTYYPFALGPRTCIGQVFSQMEAKVVLAKLLQRFEFSLVPGQ-----SFDIKDTGTLRPKSGV 493

  Fly   497 WVRLKE 502
            ...:|:
Zfish   494 ICNIKQ 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	137/462 (30%)
zgc:123299	XP_021324190.1	p450	39..495	CDD:306555	145/490 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820