Protein Alignment Cyp4aa1 and cyp46a1.3

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001027517.1
• Gene: cyp46a1.3 / 613109
• XenbaseID: XB-GENE-969052
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 526
• Identity: 140/526 - (26%)
• Similarity: 243/526 - (46%)
• Gaps: 83/526 - (15%)

  Fly    19 LILLVISLSIYTFYATLNTYLRSVLLSL-RLTGPP-----------SLPFLGNCMLVTDKDL--M 69
            |:||.:.|..:..:   :.|:..:.:.. .:.|||           .|..:.|.:|:.|..|  :
 Frog    12 LLLLALILICFLLF---SGYIHYIHMKYDHIPGPPRDSFFLGHSPTMLRLMKNNLLMYDHFLGWV 73

  Fly    70 RRCAGKAFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHN-----FLGDGL 129
            ::        ||.:|||..|......|:.||.::.:|.|.|: :|..||.::.|     |:|.||
 Frog    74 QK--------YGPVVRINGLHRVIILVVSPEAVKELLMSPKY-SKDKFYDVIANMFGVRFMGKGL 129

  Fly   130 ITSSG-SKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVG-TEINIAKYVNNCVLD 192
            :|... ..|...||::.|||....|...:..|.:.::.|.|.|..:|.| .||.:...::...||
 Frog   130 VTDRDYDHWHKQRRIMDPAFSRTYLMGLMGPFNEKAEELMEKLMEKADGKCEIKMHDMLSRLTLD 194

  Fly   193 ILNEAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQKKRLN 257
            ::.:...|:.:.....|:     :||       |...:   |::.||   .:|.|..:.......
 Frog   195 VIGKVAFGMELNSLNDDL-----TPF-------PKAIS---LVMKGI---VEMRNPMVRYSLAKR 241

  Fly   258 DFTRKM--------------IQRR-RQIQNNNNGNSERKCLLDHMIEISESNRDFTEEDIVNEAC 307
            .|.||:              |:|| :|||   :|......:|..:::.:....:...|.:::...
 Frog   242 GFIRKVQESIRLLRQTGKECIERRQKQIQ---DGEEIPVDILTQILKGAAMEEECDPEILLDNFV 303

  Fly   308 TFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMCIKEAL 372
            ||.:|||::....::|.:..|.:|||..::...|:..:. .|.|.....||.:::|:...:||.|
 Frog   304 TFFIAGQETTANQLSFVVMELGRNPEILEKAQAEIDEVI-GSKRDIEYEDLGKLQYLSQVLKETL 367

  Fly   373 RLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHP 437
            ||||:.|..:|.|.|::.:....:|....:.:..|...|:...|.||..|.|:||||:..:   |
 Frog   368 RLYPTAPGTSRGLTEDMVIDGVKVPENVTIMLNSYIMGRMEQYYSDPLTFNPDRFSPDAPK---P 429

  Fly   438 -YAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRI----TLRASGGLW 497
             |::.|||.|||.|||..|:.||.|.::::||:.|:.....|:     :|:|    |||...|:.
 Frog   430 YYSYFPFSLGPRSCIGQVFSQMEAKVVMAKLLQRYEFELAEGQ-----SFKILDTGTLRPLDGVI 489

  Fly   498 VRLKER 503
            .||:.|
 Frog   490 CRLRPR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	123/443 (28%)
cyp46a1.3	NP_001027517.1	CYP46A1-like	66..490	CDD:410706	126/462 (27%)