DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	530	Identity:	158/530 - (29%)
Similarity:	256/530 - (48%)	Gaps:	65/530 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LILLVISLS---------IYTFYATLNTYLRSVLLSLRLTGPPSLP----FLGNCMLVTDKDLMR 70
            |:||::..|         .||||....          ||...|..|    |.|:..|||..:...
Human    20 LLLLLVGGSWLLARVLAWTYTFYDNCR----------RLQCFPQPPKQNWFWGHQGLVTPTEEGM 74

  Fly    71 RCAGKAFDLYGSLVRIWV-LLFPFFAVLEPEDLQVILSSKKHT--NKVFFYRLMHNFLGDGLITS 132
            :...:....|....::|: ..||...:..|:.::.|.|:....  ..:.||..:..:|||||:.|
Human    75 KTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLS 139

  Fly   133 SGSKWSNHRRLIQPAFHHNLLEKFIDTF---VDASQSLYENLDAEAVGTEINIAKYVNNCVLDIL 194
            .|.|||.|||::.||||.|:|:.::..|   |:.....::.|.:|. ...:::.::::...||.|
Human   140 GGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEG-SARLDMFEHISLMTLDSL 203

  Fly   195 NEAVLGVPIKKRGQD------VAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQK 253
            .:.|..  .:...|:      .|::|.|.|      :..|..|..|..|.:|:.|..........
Human   204 QKCVFS--FESNCQEKPSEYIAAILELSAF------VEKRNQQILLHTDFLYYLTPDGQRFRRAC 260

  Fly   254 KRLNDFTRKMIQRRR-----QIQNNNNGNSERKCLLDH----MIEISESNRDFTEEDIVNEACTF 309
            ..::|||..:||.||     |..::...|..:...||.    ::...|..::.::|||..||.||
Human   261 HLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTF 325

  Fly   310 MLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP---TMTDLHEMRYMEMCIKEA 371
            |..|.|:..:.:::.|:.|.::||.|::|..|:..:.:|  |.|   ...||.::.::.|||||:
Human   326 MFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKD--REPIEIEWDDLAQLPFLTMCIKES 388

  Fly   372 LRLYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENR 435
            |||:|.||:|:|...::..|.. ..:|.|....|.....|....::||||.:.|.||..||.:.|
Human   389 LRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKER 453

  Fly   436 HPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRL 500
            .|.||:|||||||.|||..||:.|:|.:::..|..:::||.  .|.......:.|||.||||:|:
Human   454 SPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPT--HTEPRRKPELILRAEGGLWLRV 516

  Fly   501 KERDHPLIAH 510
            :    ||.|:
Human   517 E----PLGAN 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	134/453 (30%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	137/466 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154682
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750