Protein Alignment Cyp4aa1 and Cyp3a25

DIOPT Version :10

• Sequence 1: NP_611067.2
• Gene: Cyp4aa1 / 36752
• FlyBaseID: FBgn0034053
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_062766.2
• Gene: Cyp3a25 / 56388
• MGIID: 1930638
• Length: 503
• Species: Mus musculus
• Alignment Length: 498
• Identity: 134/498 - (26%)
• Similarity: 225/498 - (45%)
• Gaps: 60/498 - (12%)

  Fly     7 LERTTNLELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNC------MLVTD 65
            :|...||.: ...:|||.||.::..|   .||...:...|.:.||..||.||..      |...|
Mouse     1 MELIPNLSI-ETWVLLVTSLVLFYIY---GTYSHGLFKKLGIPGPKPLPLLGTIFNYYDGMWKFD 61

  Fly    66 KDLMRRCAGKAFDLYGSLVRIWVLL---FPFFAVLEPEDLQVILSSKKH---TNKVFFYRLMHNF 124
            :|..::        ||   :||...   .|..|:::||.::::|..:.:   ||:.||..:  .|
Mouse    62 EDCYKK--------YG---KIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFFGPV--GF 113

  Fly   125 LGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENL-DAEAVGTEINIAKYVNN 188
            :...:..|...:|...|.|:.|.|....|::...........|..|| ..|..|..|::......
Mouse   114 MKKAITISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPISMKDIFGA 178

  Fly   189 CVLDILNEAVLGVPIKKRGQDVAMMEDSPF-RQGKIMMPARFTQPWLL-------LDGIYHWTKM 245
            ..:|::.....||.:     |.......|| ::.|.::..:...|:||       |..||   :|
Mouse   179 YSMDVITGTSFGVNV-----DSLNNPQDPFVQKAKKILKFKIFDPFLLSIILFPFLTPIY---EM 235

  Fly   246 ANDELNQKKRLNDFTR--KMIQRRRQIQNNNNGNSERKCLLDHMIEI-----SESNRDFTEEDIV 303
            .|..:..:..:|.|.:  |.:::.|...|..|    |...|..|:..     .||.:..::.::.
Mouse   236 LNFSIFPRDSMNFFKKFVKRMKKERLASNQKN----RVDFLQLMMNTQNSKGQESQKALSDLEMA 296

  Fly   304 NEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMTD-LHEMRYMEMC 367
            .:|..|:..|.|:...:::..::.|..:|:.|.:...|:....  .|:||...| |.:|.|::|.
Mouse   297 AQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTL--PNKAPVTYDALMDMEYLDMV 359

  Fly   368 IKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENS 432
            :.|:|||||....:.|...::|.:....:|.|:.|.|..|..||....:|:|::|.|||||.||.
Mouse   360 VNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKENK 424

  Fly   433 ENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLP 475
            .|..||.::||..|||.|||.|||::.||..|..:|:::.:.|
Mouse   425 GNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQP 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	CYP4	81..498	CDD:410721	112/418 (27%)
Cyp3a25	NP_062766.2	CYP3A	67..492	CDD:410743	113/428 (26%)