DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_038935701.1	Gene:	Cyp4f40 / 503122	RGDID:	1559596	Length:	530	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	150/533 - (28%)
Similarity:	249/533 - (46%)	Gaps:	66/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LILLVISLS---------IYTFYATLNTYLRSVLLSLRLTGPPSLP----FLGNCMLVTDKDLMR 70
            |:|.::.:|         |||.||...          ||.|.|..|    |.|:..:....:...
  Rat    20 LLLSLVGVSWFLTRCLTQIYTLYAKCQ----------RLCGFPQPPKRSWFWGHLGMSPPTEEGM 74

  Fly    71 RCAGKAFDLYGSLVRIWV-LLFPFFAVLEPEDLQVILSSKKHT--NKVFFYRLMHNFLGDGLITS 132
            :...:....|......|: .:.|...:..|:.::.:||:....  ....||..:..:|||||:.|
  Rat    75 KQMTELVATYPQGFMTWLGPIVPLITLCHPDIIRSVLSASAAVAPKDGIFYSFLKPWLGDGLLVS 139

  Fly   133 SGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVG--TEINIAKYVNNCVLDILN 195
            :..|||.||.::.||||.|:|:.::..|.|::..::......|.|  ..:::.:.::...||.|.
  Rat   140 ASDKWSRHRSMLTPAFHFNILKPYVKIFNDSTNIMHAKWLRLASGGSAHLDMFENISLMTLDTLQ 204

  Fly   196 EAVLGVPIKKRGQD------VAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQKK 254
            :.|..  .....|:      .|::|.|      .::..|..|..|.:|.:|..|...........
  Rat   205 KCVFS--FNSNCQEKPSEYIAAILELS------ALVVKRNEQLLLHMDLLYRLTPDGRRFYKACH 261

  Fly   255 RLNDFTRKMIQRRRQIQNNNNGNSERKC-----LLDH----MIEISESNRDFTEEDIVNEACTFM 310
            .::|||..:||.||:....:.|:...|.     .||.    ::...|..::.::|||..||.|||
  Rat   262 LVHDFTYAVIQERRRTLPKHGGDDVIKAKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFM 326

  Fly   311 LAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP--------TMTDLHEMRYMEMC 367
            ..|.|:..:.:::.|:.|.::||.|:||..|:..:..|.:...        ...||.::.::.||
  Rat   327 FEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDSEEIECSCGVLLRDDLAQLPFLTMC 391

  Fly   368 IKEALRLYPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPEN 431
            |||:|||:|.|.:::|...:::.|.. ..:|.|....|..:|||....::.|||.:.|.||.|||
  Rat   392 IKESLRLHPPVTMVSRCCTQDISLPDGRVIPKGIICIINIFATHHNPTVWQDPEVYDPFRFDPEN 456

  Fly   432 SENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGL 496
            .:.|.|.||:|||||||.|||..||:.|:|..|:..|..:::||...:.....  .:.|||..||
  Rat   457 IQARSPLAFIPFSAGPRNCIGQTFAMNEMKVAVALTLLRFRVLPDDKEPRRKP--ELILRAEDGL 519

  Fly   497 WVRLKERDHPLIA 509
            |:|::    ||.|
  Rat   520 WLRVE----PLSA 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	128/457 (28%)
Cyp4f40	XP_038935701.1	CYP4F	74..522	CDD:410772	131/457 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348448
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750