DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4f17

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001178915.1	Gene:	Cyp4f17 / 500801	RGDID:	1561655	Length:	524	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	151/518 - (29%)
Similarity:	262/518 - (50%)	Gaps:	57/518 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ILLVISLS---------IYTFYATLNTYLRSVLLSLR-LTGPPSLP-FLGNCMLVTDKDLMRRCA 73
            :|||:..|         |..||   :.|.|     || ...|||.. |.|:..||.:.:...:..
  Rat    21 LLLVVGTSLLLARILAWISAFY---DNYCR-----LRCFPQPPSRHWFWGHLNLVKNNEEGLQLL 77

  Fly    74 GKAFDLYGSLVRIWV-LLFPFFAVLEPEDLQVILSSKKHT--NKVFFYRLMHNFLGDGLITSSGS 135
            .:....:..:...|: :.:|...::.|:.:..||.:....  .::.||..:..:|||||:.|:|.
  Rat    78 AEMSHQFQDIHLCWIGIFYPILRLIHPKFIGPILQAPAAVAPKEMIFYGFLKPWLGDGLLVSAGE 142

  Fly   136 KWSNHRRLIQPAFHHNLLEKFIDTF---VDASQSLYENLDAEAVGTEINIAKYVNNCVLDILNEA 197
            |||..|||:.||||.::|:.::..|   |:...:.::.|.|:. ...:::.::::...||.|.:.
  Rat   143 KWSRQRRLLTPAFHFDILKPYVKNFNKSVNIMHAKWQRLTAKG-SARLDMFEHISLMTLDSLQKC 206

  Fly   198 VLGVPIKKRGQDVAMMEDSP------FRQGKIMMPARFTQPWLLLDGIYHWTKMANDELNQKKRL 256
            |....        :..::||      .::...::..|..||:|.:|.:|:.|............:
  Rat   207 VFSFD--------SNCQESPSEYIAAIQELSSLIVKRHHQPFLYMDFLYYLTADGRRFRKACDLV 263

  Fly   257 NDFTRKMIQRRRQIQNNNNGN----SERKCLLDHMIEI-----SESNRDFTEEDIVNEACTFMLA 312
            ::||..:|:.||:..::.:.:    |:.|......|::     .|..::.::|||..||.|||..
  Rat   264 HNFTDAVIRERRRTLSSQSVDEFLKSKTKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFG 328

  Fly   313 GQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP---TMTDLHEMRYMEMCIKEALRL 374
            |.|:..:|:::.|:.|.::||.|:||..|:..:..|  |.|   ...||.::.::.|||||:|||
  Rat   329 GHDTTASALSWILYNLARHPEHQERCRQEVRELLRD--REPEEIEWDDLTQLPFLTMCIKESLRL 391

  Fly   375 YPSVPLIARKLGEEVRLAK-HTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPY 438
            :|.|.:|:|...::|.|.. ..:|.|::..|..:..|....::||||.:.|.||..||.:.|.|.
  Rat   392 HPPVTVISRCCTQDVVLPDGRVIPKGNDCIISIFGVHHNPSVWPDPEVYDPFRFDSENPQKRSPL 456

  Fly   439 AFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLK 501
            ||:|||||||.|||..||:.|:|..|:..|..::|||...:.....  .:.|||.||||:|::
  Rat   457 AFIPFSAGPRNCIGQTFAMNEMKVAVALTLLRFRLLPDDKEPRRKP--ELILRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	130/450 (29%)
Cyp4f17	NP_001178915.1	p450	52..514	CDD:278495	138/474 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348441
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750