DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4d14

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	171/525 - (32%)
Similarity:	267/525 - (50%)	Gaps:	53/525 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LELCSILILLVISLSIYTFYATLNTYLR-----SVLLSLRLTGPPSLPFLGNCMLVTDKDLMRRC 72
            |||.:||:...::..          |:|     .:.....:.||.|.|.:||..|:.::.  .:.
  Fly     3 LELFAILLATALAWD----------YMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINES--PKS 55

  Fly    73 AGKAFDL-------YGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLMHNFLGDGLI 130
            ....||:       :|..::..:|....|...:.:.::.|:||::...|...|.|:.|:|||||:
  Fly    56 KSSIFDMQFRLIAEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLL 120

  Fly   131 TSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDAS----QSLYENLDAEAVGTEINIAKYVNNCVL 191
            .|.|.||...|::|.||||..:||.|::.|...|    |.||:..|.:.|   ||:......|.:
  Fly   121 ISQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTV---INMFPVACLCAM 182

  Fly   192 DILNEAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDGI--YHWTKMANDELNQK- 253
            ||:.|..:||.|..:.|.......| ......|:..||..|...||..  ..:.|:. |:||..
  Fly   183 DIIAETAMGVKINAQLQPQFTYVQS-VTTASAMLAERFMNPLQRLDFTMKLFYPKLL-DKLNDAV 245

  Fly   254 KRLNDFTRKMIQRRRQIQN--------------NNNGNSERKCLLDHMIEISESNRDFTEEDIVN 304
            |.::|||..:|..||::..              |:.|...|..|||.:::.:......:.:||..
  Fly   246 KNMHDFTNSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPLSNDDIRE 310

  Fly   305 EACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAP-TMTDLHEMRYMEMCI 368
            |..|||..|.|:..:::|||.:||.::||.|.|...|:..:..|...|| ||..|.|::|:|..|
  Fly   311 EVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVI 375

  Fly   369 KEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSE 433
            ||:|||:||||:|.|.:.::..|....:||.|||.|..|...|....:||||||.|:|||.|...
  Fly   376 KESLRLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKG 440

  Fly   434 NRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWV 498
            ...|:|:.|||||||.|||.:||::|:|:.:|:::|.::|||:..:  :.....:.||::.|:..
  Fly   441 EISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPLGEE--VQPVLNVILRSTTGINC 503

  Fly   499 RLKER 503
            .||.|
  Fly   504 GLKPR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	156/453 (34%)
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	158/463 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460473
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000