DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp4a30b

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_006503285.1	Gene:	Cyp4a30b / 435802	MGIID:	3717145	Length:	510	Species:	Mus musculus

Alignment Length:	561	Identity:	153/561 - (27%)
Similarity:	244/561 - (43%)	Gaps:	123/561 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LERTTN-------LELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCMLVT 64
            |...||       |::.|:|.||::.|....:|......::|  |......||.....||.:  .
Mouse     6 LSHITNVFGIFGLLQVVSLLGLLLLLLKSAQYYLHRQWLIKS--LQQFPPAPPPQWLFGNTL--K 66

  Fly    65 DKDLMR--RCAGKAFD------LYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVFFYRLM 121
            |:||.:  .|..| |.      |:|:..|:        .:.:|:.::||| .:.....|..|...
Mouse    67 DQDLQQILLCVEK-FPSTYVRWLWGNHARV--------VIYDPDYMKVIL-GRSDPKVVRSYSFF 121

  Fly   122 HNFLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLD--AEAVGTEINIAK 184
            ..::|.||:..:|.||..|||::.||||:::|:.::...||   |::..||  .:.|.
Mouse   122 APWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVGIMVD---SVHVMLDKWEQLVD------- 176

  Fly   185 YVNNCVLDILNEAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLLDGIYHWTKMANDE 249
              .:|.|:|.             ||:::|      ..:.||...|:         |..:....|.
Mouse   177 --QDCPLEIY-------------QDISLM------TMETMMKCAFS---------YQGSVQLEDC 211

  Fly   250 LNQK---KRLNDFTRKMIQRRRQ--IQNN------NNGNS-----------------ERKCLLDH 286
            .|.|   |.:.|.|..:..|.|.  .|||      :||.|                 .||..|.:
Mouse   212 RNSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSSNGRSFYHACQIAHKHTERVIRMRKAQLQN 276

  Fly   287 MIEI-------------------SESNRDFTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNP 332
            ..|:                   :|..:..::||:..|..|||..|.::..:.:::..:.|..:|
Mouse   277 EAELEKFRKKKRLDFLDILLFAQTEDGKSLSDEDVRAEMDTFMFEGHNTTASGISWIFYALATHP 341

  Fly   333 ECQDRCVLELATIFEDSNRAPTMTDLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKH-TL 396
            |.|.||..|:.:|. .:..:.|:..|.:|.|..|||||||||||.:|..:|:|...|..... :|
Mouse   342 EHQQRCREEVKSIL-GNGTSVTLNHLDQMPYTTMCIKEALRLYPPIPGASRELSSPVTFPDGCSL 405

  Fly   397 PAGSNVFICPYATHRLAHIYPDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIK 461
            |.|..|.:..|..|....:.|:.|.|.|.||:|  ...|..:||||||||.|.|||.:|.:.|:|
Mouse   406 PKGFLVTLSFYGLHHNPRLRPNAEVFDPSRFAP--GAPRQTHAFLPFSAGTRNCIGKQFTMNELK 468

  Fly   462 TIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLKE 502
            ..|:..|..::|||...:..|..: :|.|::..|:::..|:
Mouse   469 VAVALTLLRFELLPDPTRVPILVS-KIVLKSKNGIYLHTKK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	134/482 (28%)
Cyp4a30b	XP_006503285.1	p450	59..504	CDD:365848	138/500 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750