DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4aa1 and Cyp313a1

DIOPT Version :9

Sequence 1:	NP_611067.2	Gene:	Cyp4aa1 / 36752	FlyBaseID:	FBgn0034053	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	133/512 - (25%)
Similarity:	241/512 - (47%)	Gaps:	44/512 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCM--LVTDKDLMRRCA--GK 75
            :.:|.:||.:....:.::  |.:..|...|.|::.||..||.||:.:  ::|.|   |:.:  .|
  Fly     1 MLTINLLLAVGALFWIYF--LWSRRRLYFLMLKIPGPIGLPILGSSLENIITYK---RKLSFRTK 60

  Fly    76 AFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKK-HTNKVFFYRLMHNFLGDGLITSSGSKWSN 139
            ..:.|||.:..|:...||....:|:.::.|.||.. |.........:.:.:|:||:......|.:
  Fly    61 YLNKYGSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLD 125

  Fly   140 HRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAVGTEINIAKYVNNCVLDILNEAVLGVPIK 204
            .|:...|:|..:||..|...|...::.|...||......||::...:......|..:..:|..:|
  Fly   126 RRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPEMLRWSFKIAAQTTMGSEVK 190

  Fly   205 KRGQDVAMMEDSPFRQG---------------KIMMPARFTQPWLLLDGIYHWTKMANDELNQKK 254
                     .|..|:.|               .|:||....:   ::..|..:.|:..|..::.:
  Fly   191 ---------HDEHFKNGSLVESFESLISHSTLNILMPLVQNR---MISKICGYDKLRADNFSRIQ 243

  Fly   255 RLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEISESNRDFTEEDIVNEACTFMLAGQDSVGA 319
            ::.|   .::.::.......:.:.|...:::..:|:.... |.|..|:.:|.|..:.||.|:...
  Fly   244 KMLD---NVVNKKVNPLPKTDSDPESNIVINRAMELYRKG-DITYMDVKSECCIMIAAGYDTSAL 304

  Fly   320 AVAFTLFLLTQNPECQDRCVLELATIFEDSNR-APTMTDLHEMRYMEMCIKEALRLYPSVPLIAR 383
            .|...||||..:||.|:....||..:|.|:.. ..|..|:.::.|:|..|||.|||.|::|:.||
  Fly   305 TVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLRLIPAIPITAR 369

  Fly   384 KLGEEVRLAKHTL-PAGSNVFICPYATHRLAHIY-PDPEKFQPERFSPENSENRHPYAFLPFSAG 446
            :...:|||:...| |.|..:.|..:.|||...:: ||.:.|.|:.|..||.|.:||||::||:.|
  Fly   370 ETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPYAYIPFARG 434

  Fly   447 PRYCIGNRFAIMEIKTIVSRLLRSYQLLPVTGKTTIAATFRITLRASGGLWVRLKER 503
            .|.|||:::|:|..|..:.|:||:|::...|....:.....:|::.:....::|:.|
  Fly   435 KRNCIGSKYAMMSSKFALCRILRNYKISTSTLYKDLVYVDNMTMKLAEYPRLKLQRR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4aa1	NP_611067.2	p450	50..475	CDD:278495	122/447 (27%)
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	122/448 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	102	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1194
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	5	4.960